The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Interplay of Ferroptosis, Cuproptosis, Autophagy and Pyroptosis in Male Infertility: Molecular Crossroads and Therapeutic Opportunities DOI Open Access

Dong-Zhen Cai,

Junda Li, Peng Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3496 - 3496

Published: April 8, 2025

Male infertility is intricately linked to dysregulated cell death pathways, including ferroptosis, cuproptosis, pyroptosis, and autophagy. Ferroptosis, driven by iron-dependent lipid peroxidation through the Fenton reaction inactivation of GPX4/Nrf2/SLC7A11 axis, disrupts spermatogenesis under conditions oxidative stress, environmental toxin exposure, or metabolic disorders. Similarly, cuproptosis—characterized mitochondrial dysfunction disulfide stress due copper overload—exacerbates germ apoptosis via FDX1 activation NADPH depletion. Pyroptosis, mediated NLRP3 inflammasome gasdermin D, amplifies testicular inflammation loss IL-1β/IL-18 release, particularly in response insults. Autophagy maintains homeostasis clearing damaged organelles proteins; however, its dysregulation impairs sperm maturation compromises blood–testis barrier integrity. These pathways intersect shared regulators; reactive oxygen species mTOR modulate autophagy–pyroptosis balance, while Nrf2 bridge ferroptosis–cuproptosis crosstalk. Therapeutic interventions targeting these mechanisms have shown promise preclinical models. However, challenges persist, tissue-specific roles isoforms, off-target effects pharmacological inhibitors, transgenerational epigenetic impacts toxins. This review synthesizes current molecular insights into implicated male infertility, emphasizing their interplay translational potential for restoring spermatogenic function.

Language: Английский

Citations

0
The interplay of oxidative stress, apoptotic signaling, and impaired mitochondrial function in the pyrethroid-induced cardiac injury: Alleviative role of curcumin-loaded chitosan nanoparticle DOI
Alaa S. Alhegaili, Duaa Abdullah Bafail,

Ahmed Abdulwahab Bawahab

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 194, P. 115095 - 115095

Published: Nov. 6, 2024

Language: Английский

Citations

0
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Citations

0