Türk doğa ve fen dergisi :/Türk doğa ve fen dergisi,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Aspirin
is
one
of
the
most
widely
used
non-steroidal
anti-inflammatory
drugs
worldwide.
Neurodegenerative
diseases
adversely
affect
central
nervous
system,
leading
to
cognitive
decline.
has
different
pharmacological
activities
at
doses.
Therefore,
this
study
aimed
determine
effects
acetylsalicylic
acid
(ASA),
active
ingredient
aspirin,
administered
doses
on
parameters
that
play
a
role
in
function
using
molecular
and
histological
methods
behavioral
tests.
For
purpose,
28
Wistar
rats
were
divided
into
4
groups.
Control,
ASA-low
dose
(1mg/kg),
ASA-moderate
(10mg/kg)
ASA-high
(100mg/kg).
ASA
was
intragastrically
as
single
dose,
an
open
field
test
performed
3
hours
later.
Subsequently,
hippocampus
tissues
obtained,
tissue
structure
analyzed
by
analyzing
involved
antioxidant
capacity,
inflammation,
apoptosis,
memory.
ASA,
especially
moderate
doses,
increased
capacity
partially
reduced
inflammation
apoptotic
damage.
At
high
opposite
effect
observed,
damage
levels.
Similar
detected
examination.
Although
there
no
structural
defects
low
or
observed
difference
findings
between
groups,
time
spent
center,
distance
traveled,
speed
slightly
higher
moderate-dose
group.
In
conclusion,
may
contribute
improvement
However,
cause
impairment.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2024,
Volume and Issue:
38(10)
Published: Sept. 24, 2024
Arsenic
is
a
toxic
environmental
pollutant
heavy
metal,
and
one
of
its
critical
target
tissues
in
the
body
liver.
Carvacrol
natural
phytocompound
that
stands
out
with
antioxidant,
anti-inflammatory,
antiapoptotic
properties.
The
current
study
aims
to
investigate
protective
feature
carvacrol
against
sodium
arsenite-induced
liver
toxicity.
Thirty-five
Sprague-Dawley
male
rats
were
divided
into
five
groups:
Control,
Sodium
arsenite
(SA),
CRV,
SA
+
CRV25,
CRV50.
was
administered
via
oral
gavage
at
dose
10
mg/kg
for
14
days,
30
min
later,
CRV
25
or
50
gavage.
Oxidative
stress,
inflammation,
apoptosis,
autophagy
damage
pathways
parameters,
tissue
integrity
analyzed
using
biochemical,
molecular,
western
blot,
histological,
immunohistological
methods.
decreased
oxidative
stress
by
suppressing
malondialdehyde
levels
increasing
superoxide
dismutase,
catalase,
glutathione
peroxidase
activities,
levels.
reduced
inflammation
reducing
increased
NF-κB
cytokines
(TNF-α,
IL-1β,
IL-6,
RAGE,
NLRP3)
it
stimulates.
also
autophagic
(Beclin-1,
LC3A,
LC3B)
apoptotic
(P53,
Apaf-1,
Casp-3,
Casp-6,
Casp-9,
Bax)
parameters.
preserved
impaired
structure.
alleviated
increases
parameters
rat
tissues.
beneficial
preserving
integrity.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: March 1, 2025
ABSTRACT
Cyclophosphamide
(CYP)
is
an
extensively
used
immunosuppressive
drug
and
chemotherapeutic
agent
for
various
malignancies.
Nevertheless,
its
use
limited
due
to
adverse
effects,
including
nephrotoxicity.
Saxagliptin
a
DPP4
inhibitor,
while
cilostazol
serves
as
antiplatelet
agent.
Their
nephroprotective
effects
arise
from
antioxidant
anti‐inflammatory
properties.
This
study
investigated
the
potential
protective
of
Cilostazol
in
rats
with
kidney
damage
induced
by
CYP.
Five
equal
groups
50
male
Wistar
were
randomly
categorised
Group
I
(Control
group),
II:
CYP
untreated
nephrotoxicity–induced
group,
III:
Nephrotoxicity‐induced
group
treated
saxagliptin,
IV:
cilostazol,
V:
saxagliptin
cilostazol.
Renal
tissues
blood
samples
collected
biochemical
analysis
urea,
creatinine,
acute
injury
biomarkers,
Kim‐1
NGAL.
Additionally,
oxidative
stress
inflammatory
biomarkers
such
GSH,
MDA,
TNF‐α
IL‐1β
assessed,
along
gene
expression
Nrf‐2/HO‐1
NF‐kB
.
Immunohistochemical
iNOS,
histopathological
also
conducted.
ameliorated
nephrotoxicity
CYP,
indicated
improvements
Furthermore,
there
was
decrease
via
upregulation
,
increased
levels
downregulation
MDA
decreased
inflammation
TNF‐α,
iNOS/
The
combination
demonstrated
significant
improvement
compared
using
each
individually.
Saxagliptin/Cilostazol
superior
monotherapy
either
alone
preventing
CYP‐induced
Journal of Complementary and Integrative Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Abstract
Objectives
The
use
of
medications
for
the
treatment
various
diseases
often
results
in
kidney
damage.
Apitherapy
is
a
natural
therapeutic
tool
with
potential
utility
this
purpose.
This
narrative
review
analyzes
and
summarizes
scientific
evidence
on
apitherapy
drug-induced
disease.
Content
recent
advances
disease
explores,
based
available
evidence,
how
can
modify
these
mechanisms
be
utilized
prevention
treatment.
Summary
(the
complementary
integrative
beehive
products)
potentially
useful
system
diseases.
examines
preclinical
clinical
regarding
its
Outlook
has
effects
pathophysiological
disease,
including
oxidative
stress,
inflammation,
decreased
renal
blood
flow,
glomerular
damage,
increased
membrane
permeability,
activity
renin-angiotensin-aldosterone
axis,
mitochondrial
dysfunction,
apoptosis.
Further
studies
humans
are
needed
to
evaluate
efficacy
setting,
but
promising.
Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
Tramadol
(TRM)
is
a
synthetic
opioid
analgesic
that
acts
on
the
central
nervous
system
and
used
to
treat
moderate
or
severe
pain.
However,
incidence
of
its
abuse
increasing.
Rosmarinic
acid
(RA)
natural
flavonoid
known
for
antioxidant,
anti-inflammatory,
neuroprotective
properties.
In
this
study,
we
determined
ameliorative
effects
RA
against
TRM-induced
neurotoxicity.
Thirty
five
rats
were
divided
into
5
groups;
control,
RA,
TRM,
TRM
+
RA25
RA50.
50
mg/kg
was
administered
intraperitoneally,
25
doses
by
oral
gavage
14
days.
Water
Maze
Test
(WMT)
performed
assess
cognitive
function.
Oxidative
stress,
inflammation,
endoplasmic
reticulum
(ER)
apoptosis
damage
pathways,
glial
fibrillary
acidic
protein
(GFAP),
brain-derived
neurotrophic
factor
(BDNF)
activities
in
brain
hippocampus
tissues.
The
structural
functional
integrity
tissues
also
analyzed.
decreased
increased
oxidative
ER
apoptotic
levels.
addition,
it
improved
neuronal
survival
activity
bringing
BDNF
GFAP
closer
normal
tissue.
restored
properties
disrupted
tramadol.
These
findings
demonstrated
using
WMT,
which
arrival
time
quadrant
platform
located
spent
quadrant.
reduces
neurotoxicity
reducing
oxidative
increases
activity.
Bratislavské lekárske listy/Bratislava medical journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Abstract
Aim
Alkali-esophageal
burn
due
to
ingestion
of
corrosive
substances
is
an
important
clinical
entity
that
can
be
seen
in
all
age
groups,
especially
children.
Chrysin
a
natural
flavonoid
compound
with
wide
range
biological
activities,
including
antioxidant,
anti-inflammatory,
antiapoptotic,
and
anticancer
effects.
This
study
aimed
ascertain
the
preventive
efficacy
chrysin
treatment
alkali-esophageal
burns.
Materials
Methods
Rats
were
administered
0.2
ml
25%
NaOH
orally
CHR
at
25
50
mg/kg
intraperitoneally
for
four
days.
The
levels
oxidative
stress,
ER
inflammation,
damage,
apoptotic
autophagic
cell
death
esophageal
tissues
analyzed
using
biochemical
molecular
methods.
Additionally,
tissue
structure
function
examined
histological
Results
alleviated
NaOH-induced
increased
stress
by
decreasing
MDA
increasing
antioxidants.
inflammation
damage
inhibiting
NF-κB
signaling
pathway.
decreased
Caspase-3,
Bax
antiapoptotic
Bcl-2.
Moreover,
reduced
damage.
facilitated
restoration
impaired
structural
integrity
Ki-67
EGF
levels,
contributing
healing
process.
Conclusion
exhibited
anti-autophagic,
anti-oxidant
properties
alkali
burns,
as
well
effect
on
reducing
injury.
facilitates
maintains
integrity.
Graphical
abstract
