zMicroplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats DOI Creative Commons
Damir Suljević, Patrik Karlsson, Muhamed Fočak

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109421 - 109421

Published: March 1, 2025

The environmental fragmentation of plastics generates a mixture plastic particles various sizes, which frequently co-occur with other mobile and persistent pollutants. Despite the prevalence such scenarios, interaction between micro- nanoplastics (MNPs) their combined effects pollutants, as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic microplastic co-aggregate together influence Cr bioaccumulation patterns related physiological alterations rats. Following four-week repeated intragastric exposure Wistar rats to MNPs Cr(VI), either alone or combination, significantly enhanced liver, heart, brain, skin. Under co-exposure conditions, Cr(VI) was primary driver cellular observed blood, including shifts immune cell subpopulations (e.g., neutrophils, lymphocytes) red blood indices, while serum biochemistry reflected limited stress. per se decreased creatine kinase activity increased cholesterol levels. In summary, polystyrene increase distribution bioavailability, but does not uniformly exacerbate toxicity. Instead, may selectively alter responses, emphasizing need for deeper understanding potential health risks.

Language: Английский

zMicroplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats DOI Creative Commons
Damir Suljević, Patrik Karlsson, Muhamed Fočak

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109421 - 109421

Published: March 1, 2025

The environmental fragmentation of plastics generates a mixture plastic particles various sizes, which frequently co-occur with other mobile and persistent pollutants. Despite the prevalence such scenarios, interaction between micro- nanoplastics (MNPs) their combined effects pollutants, as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic microplastic co-aggregate together influence Cr bioaccumulation patterns related physiological alterations rats. Following four-week repeated intragastric exposure Wistar rats to MNPs Cr(VI), either alone or combination, significantly enhanced liver, heart, brain, skin. Under co-exposure conditions, Cr(VI) was primary driver cellular observed blood, including shifts immune cell subpopulations (e.g., neutrophils, lymphocytes) red blood indices, while serum biochemistry reflected limited stress. per se decreased creatine kinase activity increased cholesterol levels. In summary, polystyrene increase distribution bioavailability, but does not uniformly exacerbate toxicity. Instead, may selectively alter responses, emphasizing need for deeper understanding potential health risks.

Language: Английский

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