American Journal of Reproductive Immunology,
Journal Year:
2023,
Volume and Issue:
89(6)
Published: May 11, 2023
To
retrospectively
investigate
whether
the
oral
administration
of
prednisone
acetate
with
doxycycline
increases
cure
rate
chronic
endometritis
(CE)
and
improves
in
vitro
fertilization
(IVF)
outcomes
patients
repeated
implantation
failure
(RIF)
CE.In
total,
352
RIF
were
investigated,
128
whom
diagnosed
CE
by
hysteroscopy
endometrial
immunohistochemical
analysis.
The
divided
into
CD138-positive
high-power
field
(HPF)
counts
1-2
≥3.
Forty-five
orally
administered
tablet
5
mg
daily
100
twice
for
14
consecutive
days
(group
A),
55
B)
underwent
sampling
histological
assessment.
Twenty-eight
C)
did
not
receive
any
treatment.
final
reproductive
frozen-thawed
embryo
transfer
cycle
compared.The
total
rate,
CE(CD138+
HPF
counts:
1-2),
≥3)
showed
no
significant
difference
between
groups
A
B.
Logistics
regression
analysis
indicated
that
human
chorionic
gonadotropin
(hCG)-positive
clinical
pregnancy
fetal
heartbeat
on
day
30
(D30),
ongoing
was
significantly
higher
group
than
C.
For
CE-cured
after
treatment,
hCG-positive
D30,
B.CE
is
closely
related
to
occurrence,
combined
can
be
a
treatment
option
outcomes,
although
it
does
improve
compared
alone.
Diagnostics,
Journal Year:
2022,
Volume and Issue:
12(9), P. 2250 - 2250
Published: Sept. 18, 2022
This
systematic
review
and
meta-analysis
aims
to
evaluate
the
impact
of
chronic
endometritis
(CE)
its
therapy
on
in
vitro
fertilization
(IVF)
outcome.
Additionally,
we
aim
investigate
whether
various
degrees
CE
severity
may
exert
a
different
effect
IVF
Ongoing-pregnancy
rate/live-birth-rate
(OPR/LBR),
clinical-pregnancy
rate
(CPR),
miscarriage
(MR)
were
calculated.
A
total
number
4145
patients
(from
ten
studies)
included.
Women
with
had
lower
OPR/LBR
(OR
1.97,
p
=
0.02)
CPR
2.28,
0.002)
compared
those
without
CE.
cure
increased
5.33,
<
0.0001)
3.64,
0.0001).
outcome
was
comparable
between
women
cured
(OPR/LBR,
MR:
ns).
severe
0.43,
0.003)
0.40,
0.0007)
mild
Mild
showed
no
influence
as
Based
this
data
analysis,
significantly
reduces
undergoing
IVF.
Importantly,
resolution
after
antibiotic
improves
outcome,
leading
similar
unaffected
patients.
The
negative
effects
be
restricted
disease,
whereas
have
success.
Diagnostics,
Journal Year:
2022,
Volume and Issue:
12(11), P. 2711 - 2711
Published: Nov. 5, 2022
Chronic
endometritis
(CE)
is
a
local
mucosal
infectious
and
inflammatory
disorder
characterized
by
unusual
filtration
of
CD138(+)
endometrial
stromal
plasmacytes.
CE
attracting
attention
due
to
its
potential
association
with
infertility
unknown
etiology,
repeated
implantation
failure,
recurrent
pregnancy
loss,
several
maternal/neonatal
complications.
Due
the
variance
in
study
design
among
researchers,
universal
diagnostic
criteria
remain
be
established
for
clinical
diagnosis
management
CE.
This
review
article
aims
summarize
current
knowledge
provide
insights
into
unsolved
questions
on
establish
guidelines
disease
from
viewpoint
human
reproduction.
Diagnostics,
Journal Year:
2023,
Volume and Issue:
13(5), P. 936 - 936
Published: March 1, 2023
Chronic
endometritis
(CE)
is
a
localized
mucosal
infectious
and
inflammatory
disorder
marked
by
infiltration
of
CD138(+)
endometrial
stromal
plasmacytes
(ESPC).
CE
drawing
interest
in
the
field
reproductive
medicine
because
its
association
with
female
infertility
unknown
etiology,
endometriosis,
repeated
implantation
failure,
recurrent
pregnancy
loss,
multiple
maternal/newborn
complications.
The
diagnosis
has
long
relied
on
somewhat
painful
biopsy
histopathologic
examinations
combined
immunohistochemistry
for
CD138
(IHC-CD138).
With
IHC-CD138
only,
may
be
potentially
over-diagnosed
misidentification
epithelial
cells,
which
constitutively
express
CD138,
as
ESPCs.
Fluid
hysteroscopy
emerging
an
alternative,
less-invasive
diagnostic
tool
that
can
visualize
whole
uterine
cavity
real-time
enables
detection
several
unique
findings
associated
CE.
biases
hysteroscopic
CE;
however,
are
inter-observer
intra-observer
disagreements
interpretation
endoscopic
findings.
Additionally,
due
to
variances
study
designs
adopted
criteria,
there
exists
some
dissociation
among
researchers.
To
address
these
questions,
novel
dual
another
plasmacyte
marker
myeloma
oncogene
1
currently
being
tested.
Furthermore,
computer-aided
using
deep
learning
model
developed
more
accurate
These
approaches
have
potential
contribute
reduction
human
errors
biases,
improvement
performance
CE,
establishment
unified
criteria
standardized
clinical
guidelines
disease.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Background
Intended
to
investigate
the
potential
effects
of
endometrial
preparation
procedures
on
results
subsequent
frozen
embryo
transfer
(FET)
cycles
in
infertile
women
with
chronic
endometritis
(CE)
following
a
single
course
antibiotic
therapy.
Methods
From
July
2020
December
2023,
773
patients
participated
retrospective
research.
CD138
was
immunostained
tissues
taken
during
proliferative
phase.
CE
suggested
by
presence
CD138-positive
cells
stromal
cells.
Oral
antibiotics
were
administered
every
patient
diagnosis.
After
cured,
had
transfers
and
preparation.
This
study
compared
impact
different
techniques
pregnancy
outcomes.
Results
Hormone
replacement
treatment
(HRT),
ovulation
induction,
natural
cycle,
gonadotrophin-releasing
hormone
agonist-HRT
(GnRH
agonist-HRT)
regimens
did
not
significantly
alter
outcome
CE.
Compared
other
groups,
induction
cycle
group
higher
clinical
rate
implantation
rate.
However,
miscarriage
is
lower
populations.
Patients
treated
who
received
HRT,
GnRH
agonist-HRT,
differ
substantially
(P
>
0.05).
Conclusion
cured
see
any
change
outcomes
as
result
procedures.
