Clinical and Experimental Obstetrics & Gynecology,
Journal Year:
2025,
Volume and Issue:
52(3)
Published: March 19, 2025
Background:
The
relationship
between
adenomyosis
and
vitamin
D
remains
largely
unexplored.
However,
emerging
evidence
suggests
that
deficiency
may
increase
the
risk
of
developing
adenomyosis.
Methods:
A
cross-sectional
study
was
conducted
involving
190
patients
diagnosed
with
185
healthy
controls.
Propensity
score
matching
(PSM)
utilized
to
generate
91
matched
pairs.
Multivariate
logistic
regression
analysis
employed
examine
levels
Additionally,
receiver
operating
characteristic
(ROC)
curve
used
evaluate
diagnostic
performance
levels.
Results:
In
both
unmatched
(44.0
nmol/L
vs.
61.4
nmol/L,
p
<
0.001)
(42.3
60.7
groups,
exhibited
significantly
lower
serum
compared
demonstrated
a
negative
association
in
groups.
ROC
identified
an
optimal
threshold
44.75
for
predicting
Conclusions:
Reduced
represent
independent
factor
adenomyosis,
below
associated
increased
risk.
These
findings
suggest
supplementation
serve
as
potential
preventive
strategy
against
Journal of Ultrasound in Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Objective
To
examine
whether
the
co‐occurrence
of
endometriosis
affects
sonographic
features
adenomyosis
based
on
revised
Morphological
Uterus
Sonographic
Assessment
(MUSA)
criteria.
Methods
This
prospective
cohort
study
utilized
data
from
a
tertiary
referral
center
collected
between
2010
and
2022.
Non‐pregnant
women
aged
20–53
years
who
presented
with
symptoms
potentially
related
to
underwent
pelvic
ultrasound
scans
were
included.
Diagnoses
MUSA
criteria,
which
distinguish
direct
(endometrial
cysts,
hyperechogenic
islands,
echogenic
sub‐endometrial
lines,
buds)
indirect
(globular
shape
uterus,
asymmetrical
uterine
wall
thickening,
irregular
junctional
zone,
fan‐shaped
shadowing,
translesional
vascularity,
interrupted
zone).
Patients
categorized
into
2
groups:
1)
concurrent
2)
isolated
adenomyosis.
Demographic
clinical
characteristics
retrospectively
collected.
Results
Ninety‐four
patients
diagnosed
Of
these,
24
(27%)
had
endometriosis,
while
70
The
most
frequent
globular
configuration
(52%),
myometrial
cysts
(44%),
thickening
(33%).
group
higher
proportion
(29%)
both
(33%)
compared
group,
predominantly
exhibited
(71%)
(
P
<
.05).
Direct
significantly
more
in
(51%)
(21%,
=
.01).
Conclusions
Utilizing
criteria
revealed
significant
differences
symptomatic
highlights
necessity
for
standardized
diagnostic
methods
enhances
understanding
complex
relationship
underscoring
importance
accurate
diagnosis
practice.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: March 1, 2025
Abstract
Endometriosis,
characterized
by
the
growth
of
uterine‐like
tissue
outside
uterus,
causes
chronic
pain
and
infertility.
Current
diagnostic
therapeutic
strategies
have
notable
limitations,
including
delayed
diagnosis
adverse
effects.
The
transcription
factor
forkhead
box
A2
(FOXA2),
which
is
exclusively
expressed
in
uterine
glandular
epithelium,
regulates
key
genes
involved
endometrial
proliferation,
differentiation,
fertility,
hormone
response.
While
FOXA2
expression
reduced
women
with
endometriosis,
its
pathophysiological
role
disease
not
well
understood.
In
this
study,
we
report
that
endometriosis
significantly
eutopic
endometrium
mice
compared
to
sham
controls,
accompanied
decreased
downstream
gene,
CXCL15.
To
evaluate
effect
loss
surgically
induced
transplanting
control
Rosa26
mTmG/+
or
Pgr
cre/+
Foxa2
f/f
(
d/d
)
into
peritoneal
cavity
mice.
number
weight
ectopic
lesions
were
increased
controls.
Furthermore,
progesterone
receptor
was
epithelium
from
lesions.
Importantly,
treatment
leukemia
inhibitory
(LIF),
a
cytokine
regulated
FOXA2,
lesion
formation
vehicle‐treated
This
study
demonstrates
results
an
increase
incidence
LIF
offers
novel
promising
approach
for
endometriosis.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1904 - 1904
Published: March 12, 2025
Endometriosis,
a
prevalent
gynecological
condition
affecting
10–15%
of
reproductive-age
women,
involves
the
growth
endometrial-like
tissue
outside
uterine
cavity.
This
chronic
inflammatory
disease
can
significantly
impact
fertility
by
disrupting
ovulation,
tubal
transport,
and
implantation.
Clinical
manifestations
vary
widely,
ranging
from
asymptomatic
cases
to
severe
pelvic
pain,
dysmenorrhea,
dyspareunia.
Accurate
diagnosis
remains
challenging,
often
requiring
combination
patient
history,
clinical
examination,
imaging
studies.
paper
will
discuss
approach
endometriosis
during
first-line
appointment,
focusing
on
including
detailed
assessment
menstrual,
pelvic,
bowel
symptoms,
examination;
thorough
abdominal
palpation,
speculum
bimanual
evaluation
(particularly
role
ultrasound
in
identifying
characterizing
endometriotic
lesions,
use
#ENZIAN
classification
for
deep
infiltrating
impact);
discussion
Endometriosis
Fertility
Index
(EFI)
as
tool
assessing
potential.
comprehensive
aims
guide
clinicians
managing
effectively,
improving
outcomes
optimizing
management
strategies.
Methods:
A
literature
search
suitable
articles
published
January
1974
2024
English
language
was
performed
using
PubMed.
Results:
is
associated
with
infertility
rates
20%
68%,
mechanisms
adhesions,
inflammation,
immune
dysregulation.
The
revised
American
Society
Reproductive
Medicine
(rASRM)
were
identified
essential
tools
staging
disease.
Transvaginal
(TVS)
demonstrated
high
diagnostic
accuracy
endometriosis,
sensitivity
up
96%
specificity
99%.
EFI
emerged
valuable
predictor
natural
conception
post-surgery.
Additionally,
review
underscores
frequent
co-occurrence
adenomyosis
women
which
may
further
compromise
fertility.
Despite
advancements
techniques
systems,
variability
symptom
presentation
progression
continues
challenge
early
effective
management.
Conclusions:
reproductive
age
infertility.
describes
physical
imaging,
particularly
ultrasound,
lesions.
adoption
standardized
systems
such
enhances
prognosis,
allowing
tailored
treatment
improvements
non-invasive
methods,
challenges
persist
correlating
severity
extent,
necessitating
continued
research
into
biomarkers
novel
techniques.
coexistence
complicates
outcomes,
underscoring
need
Further
needed
enhance
detection
strategies
optimize
preservation
affected
women.
Clinical and Experimental Obstetrics & Gynecology,
Journal Year:
2025,
Volume and Issue:
52(3)
Published: March 19, 2025
Background:
The
relationship
between
adenomyosis
and
vitamin
D
remains
largely
unexplored.
However,
emerging
evidence
suggests
that
deficiency
may
increase
the
risk
of
developing
adenomyosis.
Methods:
A
cross-sectional
study
was
conducted
involving
190
patients
diagnosed
with
185
healthy
controls.
Propensity
score
matching
(PSM)
utilized
to
generate
91
matched
pairs.
Multivariate
logistic
regression
analysis
employed
examine
levels
Additionally,
receiver
operating
characteristic
(ROC)
curve
used
evaluate
diagnostic
performance
levels.
Results:
In
both
unmatched
(44.0
nmol/L
vs.
61.4
nmol/L,
p
<
0.001)
(42.3
60.7
groups,
exhibited
significantly
lower
serum
compared
demonstrated
a
negative
association
in
groups.
ROC
identified
an
optimal
threshold
44.75
for
predicting
Conclusions:
Reduced
represent
independent
factor
adenomyosis,
below
associated
increased
risk.
These
findings
suggest
supplementation
serve
as
potential
preventive
strategy
against
