American Journal of Translational Research,
Journal Year:
2024,
Volume and Issue:
16(11), P. 6274 - 6288
Published: Jan. 1, 2024
The
intestinal
microbiota
is
vast
in
type
and
quantity
it
plays
a
critical
role
regulating
various
physiological
functions
the
host,
including
function,
immune
response
energy
metabolism.
Existing
research
shows
that
flora
associated
with
hormones,
cell
cycles
ovarian
function-related
diseases
female
ovaries.
Certain
microorganisms
within
can
modulate
levels
of
hormones
secreted
by
ovary,
such
as
estrogen
androgens.
Furthermore,
an
imbalance
gut
result
altered
hormone
potentially
leading
to
related
diseases.
Studies
have
found
variety
are
closely
flora,
polycystic
ovary
syndrome
(PCOS),
insufficiency
(POI),
endometriosis
(EMS)
cancer.
Importantly,
notably
difficult
diagnose
early
often
require
prolonged
treatment
for
effective
management.
its
metabolites
patients
cancers
serve
valuable
biomarkers
diagnosis,
offering
novel
strategies
disease
screening,
stratification,
prognosis.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 22, 2024
Observational
studies
and
animal
experiments
had
suggested
a
potential
relationship
between
gut
microbiota
abundance
pathogenesis
of
endometriosis
(EMs),
but
the
relevance
this
remains
to
be
clarified.
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 9, 2024
Purpose
of
review
The
analysis
microbiome
in
association
with
female
health
is
today
a
“hot
topic”
the
main
focus
on
microbes
reproductive
tract.
Nevertheless,
recent
studies
are
providing
novel
information
possible
influence
gut
gynecological
outcomes,
especially
as
we
start
to
understand
that
an
extended
endocrine
organ
influencing
hormonal
levels.
This
summarizes
current
knowledge
health.
Recent
findings
has
been
associated
endometriosis,
polycystic
ovary
syndrome,
cancers,
and
infertility,
although
there
lack
consistency
consensus
among
due
different
study
designs
protocols
used,
general
underpowered.
Summary
interconnection
between
complex
further
research
warranted.
field
emphasizes
link
high
potential
for
diagnostic
treatment
tools
via
modulation
microenvironment.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
Background
The
human
body
harbors
greater
than
10
trillion
symbiotic,
microbial
cells
that
contribute
to
our
bodily
functions.
Emerging
evidences
suggest
dysbiosis,
especially
of
the
gut
or
urogenital
system,
may
induce
various
pathological
conditions
altered
estrobolome
and
associate
with
certain
estrogen-dependent
diseases
like
endometriosis.
present
case-control
study
analyzed
enzymatic
expressions,
bacterial
compositions,
variations
estrogen
metabolites
in
fecal,
vaginal,
urinary
samples
patients
without
ovarian
Methods
A
total
38
women
reproductive
age,
24
pathologically-proven
endometriosis
14
(control),
were
analyzed.
Recruited
provided
stool,
urine,
vaginal
before
undergoing
surgeries
for
other
benign
tumors.
Gut
assays
β-glucuronidase
β-glucosidase
conducted
using
an
ELISA
spectrophotometer.
Advanced
liquid
chromatography
mass
spectrometry
samples.
microbiota
detected
16S
ribosomal-RNA
gene
sequencing
further
classified
Institute
Genome
Sciences
bioinformatics
pipeline.
Analyses
species
composition,
diversity,
abundance
compared
between
control
groups.
Statistical
significance
was
determined
t-tests
Wilcoxon
tests
(p
<
0.05).
Results
While
similar
activities,
observed
fecal
both
groups,
group
showed
higher
prevalence
Rothia
genus
whereas
genera
such
as
Megamonas,
[Eubacterium]
coprostanoligenes_group,
Allisonella,
Ruminiclostridium_5,
hallii_group,
Negativibacillus
significantly
more
abundant
group.
Meanwhile,
besides
statistically
lower
folds
4-methoxyestrone
=
0.046),
2-methoxyestrone
0.043),
2-hydroxyestrone-3-methyl
ether
0.006),
also
revealed
abundance,
richness,
evenness.
Conclusions
current
findings
did
not
demonstrate
obvious
dysbiosis
endometriosis,
families
bacteria
two
groups
could
indicate
metabolism
disturbed
gastrointestinal
microbiota.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12242 - 12242
Published: Nov. 14, 2024
Endometriosis
is
an
oestrogen-dependent
inflammatory
disease
affecting
menstruating
women,
with
varying
levels
of
severity.
Oestrogen
dysregulation
responsible
for
chronic
inflammation,
angiogenesis,
endometrial
lesion
development,
progression,
and
infertility
during
menarche
in
afflicted
women.
The
mediators
associated
this
painful
have
been
established,
research
also
indicating
the
relationship
between
dysbiosis
manifestation.
present
several
comorbidities,
including
cancer,
cardiovascular
disease,
autoimmunity.
lack
specific
sensitive
non-invasive
diagnostic
procedures,
coupled
poor
response
to
current
therapeutic
approaches,
means
that
treatment
needs
remain
unmet.
Surgical
procedures
are
performed
remove
endometriosis
ectopic
lesions,
which
recurrence
rate
up
50%,
certain
patients
exhibiting
no
alleviation
symptoms.
This
review
aims
outline
aetiology
endometriosis,
detailing
novel
approaches
potential
namely
advanced
medical
products
(ATMPs),
stem
cell
therapy
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)
gene
editing.
timely
provides
insights
into
important
recent
modalities
may
be
applied
diagnosis
biomarkers,
microfluidic
platforms,
organoid
systems.
Undoubtedly,
reliable,
reproducible,
sensitive,
models
humans
urgently
needed
investigate
detail
debilitating
disease.
American Journal of Translational Research,
Journal Year:
2024,
Volume and Issue:
16(11), P. 6274 - 6288
Published: Jan. 1, 2024
The
intestinal
microbiota
is
vast
in
type
and
quantity
it
plays
a
critical
role
regulating
various
physiological
functions
the
host,
including
function,
immune
response
energy
metabolism.
Existing
research
shows
that
flora
associated
with
hormones,
cell
cycles
ovarian
function-related
diseases
female
ovaries.
Certain
microorganisms
within
can
modulate
levels
of
hormones
secreted
by
ovary,
such
as
estrogen
androgens.
Furthermore,
an
imbalance
gut
result
altered
hormone
potentially
leading
to
related
diseases.
Studies
have
found
variety
are
closely
flora,
polycystic
ovary
syndrome
(PCOS),
insufficiency
(POI),
endometriosis
(EMS)
cancer.
Importantly,
notably
difficult
diagnose
early
often
require
prolonged
treatment
for
effective
management.
its
metabolites
patients
cancers
serve
valuable
biomarkers
diagnosis,
offering
novel
strategies
disease
screening,
stratification,
prognosis.
