Application of Eight Machine Learning Algorithms in the Establishment of Infertility and Pregnancy Diagnostic Models: A Comprehensive Analysis of Amino Acid and Carnitine Metabolism DOI Creative Commons
Rui Zhang, Lei Zhou,

Xiaoyan Hao

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(9), P. 492 - 492

Published: Sept. 10, 2024

To explore the effects of altered amino acids (AAs) and carnitine metabolism in non-pregnant women with infertility (NPWI), pregnant without (PWI) infertility-treated (ITPW) compared (NPW, control), develop more efficient models for diagnosis pregnancy, 496 samples were evaluated levels 21 AAs 55 carnitines using targeted high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Three methods used to screen biomarkers modeling, eight algorithms build validate model. The ROC, sensitivity, specificity, accuracy training model higher than 0.956, 82.89, 66.64, 82.57%, respectively, whereas those validated 0.896, 77.67, 69.72, 83.38%, respectively. pregnancy >0.994, 96.23, 97.79, 97.69%, >0.572, 96.39, 93.03, 94.71%, Our findings indicate that may alter AA match internal environment PWI. developed demonstrated good performance high sensitivity facilitating diagnosis.

Language: Английский

Recommendations from the 2024 Australian evidence‐based guideline for unexplained infertility: ADAPTE process from the ESHRE evidence‐based guideline on unexplained infertility DOI Creative Commons
Michael Costello, Robert J. Norman, Luk Rombauts

et al.

The Medical Journal of Australia, Journal Year: 2024, Volume and Issue: 221(8), P. 438 - 446

Published: Sept. 15, 2024

Abstract Introduction The 2024 Australian evidence‐based guideline for unexplained infertility provides clinicians with recommendations the optimal diagnostic workup infertile couples to establish diagnosis of and therapeutic approach treat diagnosed in health care setting. were adapted context from rigorous, comprehensive European Society Human Reproduction Embryology (ESHRE) 2023 Evidence‐based guideline: , using ADAPTE process have been approved by National Health Medical Research Council. Main includes 40 recommendations, 21 practice points three research addressing: definition — defining frequency intercourse, age, female male factor infertility; ovulation, ovarian reserve, tubal factor, uterine laparoscopy, cervical/vaginal additional testing systemic conditions; treatment expectant management, active treatment, mechanical‐surgical procedures, alternative approaches, quality life. Changes assessment management resulting This refines addresses basic procedures not considered previous guidelines on infertility. For consideration evidence quality, efficacy, safety and, setting, feasibility, acceptability, cost, implementation ultimately recommendation strength integrated across multidisciplinary expertise consumer perspectives adapting Grading Recommendations, Assessment, Development Evaluation (GRADE) framework, which had used past formulate recommendations. also included an established data integrity check ensure could be trusted guide practice. Practice added expanded consider No underpinned high evidence, most having low or very evidence. In this context, made including those context. full technical report are publicly available online can accessed at https://www.monash.edu/medicine/mchri/infertility supported extensive translation resources, free patient ASKFertility mobile application ( https://www.askfertility.org/ ).

Language: Английский

Citations

1

Prophecy, prediction, and prognosis – can we improve the advice we give on the chance of pregnancy and treatment options for infertility? DOI Creative Commons
Robert J. Norman

Fertility and Sterility, Journal Year: 2024, Volume and Issue: 121(5), P. 715 - 716

Published: Feb. 23, 2024

Language: Английский

Citations

1

Monogram and Heat Map on Magnetic Resonance Imaging to Evaluate the Recommendation for Myomectomy in Patients with Infertility: A Pilot Study DOI
Takuya Yokoe, Masato Kita, Hidetaka Okada

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Language: Английский

Citations

0

Application of Eight Machine Learning Algorithms in the Establishment of Infertility and Pregnancy Diagnostic Models: A Comprehensive Analysis of Amino Acid and Carnitine Metabolism DOI Creative Commons
Rui Zhang, Lei Zhou,

Xiaoyan Hao

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(9), P. 492 - 492

Published: Sept. 10, 2024

To explore the effects of altered amino acids (AAs) and carnitine metabolism in non-pregnant women with infertility (NPWI), pregnant without (PWI) infertility-treated (ITPW) compared (NPW, control), develop more efficient models for diagnosis pregnancy, 496 samples were evaluated levels 21 AAs 55 carnitines using targeted high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Three methods used to screen biomarkers modeling, eight algorithms build validate model. The ROC, sensitivity, specificity, accuracy training model higher than 0.956, 82.89, 66.64, 82.57%, respectively, whereas those validated 0.896, 77.67, 69.72, 83.38%, respectively. pregnancy >0.994, 96.23, 97.79, 97.69%, >0.572, 96.39, 93.03, 94.71%, Our findings indicate that may alter AA match internal environment PWI. developed demonstrated good performance high sensitivity facilitating diagnosis.

Language: Английский

Citations

0