Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastocyst Embryo Transfer Cycles Based on Serum Progesterone levels DOI Creative Commons
Seçil İrem Arık Alpçetin, Onur İnce,

Bengisu Akçay

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles are common in assisted reproductive techniques. As the corpus luteum is absent these cycles, luteal phase support provided by administering progesterone (P4) through transvaginal, parenteral, or oral routes. Low serum levels of P4 (below 9-10 ng/mL) on day before (ET) have been associated with unfavorable cycle outcomes. The aim this study to investigate whether individualizing rescue protocols patients low improves pregnancy outcomes HRT-FET cycles. This retrospective, single-center cohort analysis includes 1257 involving 942 undergoing HRT-FET. Starting 2019, we assessed ET and adjusted MVP doses when were <10 ng/mL. In 2021, subcutaneous (SC) was routinely added alongside MVP, SC increased if study, Groups 1 2 received for support, while 3 4 additional progesterone. For P below cut-off level (10 4, dose doubled a protocol. plus groups, 15.8% 8.9% had ng/mL, respectively. Ongoing rates (OPR) clinical (CPR) did not differ between groups. Regression mixed model revealed that age, endometrial thickness, estradiol confounding factors as well independent predictors ongoing (p<0.05). Pairwise regression no significant differences groups (p>0.05). Individualizing based FET HRT may enhance either doubling vaginal increasing during administration. implemented protocol allowed achieve similar those higher levels.

Language: Английский

Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastocyst Embryo Transfer Cycles Based on Serum Progesterone levels DOI Creative Commons
Seçil İrem Arık Alpçetin, Onur İnce,

Bengisu Akçay

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles are common in assisted reproductive techniques. As the corpus luteum is absent these cycles, luteal phase support provided by administering progesterone (P4) through transvaginal, parenteral, or oral routes. Low serum levels of P4 (below 9-10 ng/mL) on day before (ET) have been associated with unfavorable cycle outcomes. The aim this study to investigate whether individualizing rescue protocols patients low improves pregnancy outcomes HRT-FET cycles. This retrospective, single-center cohort analysis includes 1257 involving 942 undergoing HRT-FET. Starting 2019, we assessed ET and adjusted MVP doses when were <10 ng/mL. In 2021, subcutaneous (SC) was routinely added alongside MVP, SC increased if study, Groups 1 2 received for support, while 3 4 additional progesterone. For P below cut-off level (10 4, dose doubled a protocol. plus groups, 15.8% 8.9% had ng/mL, respectively. Ongoing rates (OPR) clinical (CPR) did not differ between groups. Regression mixed model revealed that age, endometrial thickness, estradiol confounding factors as well independent predictors ongoing (p<0.05). Pairwise regression no significant differences groups (p>0.05). Individualizing based FET HRT may enhance either doubling vaginal increasing during administration. implemented protocol allowed achieve similar those higher levels.

Language: Английский

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