Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1304 - 1304

Published: March 14, 2025

Many aromatic herbs are conventionally used for flavoring various foods, but receive wide attention because of the variety health-related properties. The can be either fresh or as dried powders and in form extracts, essential oils, purified metabolites. In this review, main functional properties, terms antioxidant antimicrobial applications some commonly from Lamiaceae family, discussed. Herbs like oregano, rosemary, sage, thyme, summer savory, marjoram, basil possess high levels bioactive phytochemicals. They particularly rich phenolic acids, flavones, diterpenes, flavanones, with beneficial effects. phytochemical profile plants is highly influenced by genetic factors, environmental conditions, their interaction. cases extracts extraction method has a strong effect on final composition herb products. Most these related to antioxidant, antimicrobial, particular, oils have multiple fields food, feed, pharmaceutical, cosmetics, biopesticides, textile industries.

Language: Английский

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Plant secondary metabolites-mediated plant defense against bacteria and fungi pathogens

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 217, P. 109224 - 109224

Published: Oct. 20, 2024

Language: Английский

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Pharmacokinetics and Toxicity Study of a Single Intravenous Dose of Distilled Extract of Zanthoxylum piperitum in ICR Mice

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

This study aimed to investigate the pharmacokinetics and acute toxicity of a single intravenous dose distilled Zanthoxylum piperitum (deZP) extract in ICR mice. The focus was on understanding absorption, distribution, elimination Terpinen-4-ol, major active component deZP, as well assessing its safety at administered dose. mice were deZP (2.4 mg/kg), plasma concentrations Terpinen-4-ol measured using LC-MS/MS various time points. Pharmacokinetic parameters such Cmax, Tmax, half-life, clearance rate calculated. In addition, clinical signs, mortality, biochemical markers monitored evaluate toxicity. rapidly absorbed, reaching peak concentration (Cmax) 609.0 ng/mL within 0.083 hours (Tmax). It exhibited short half-life 0.168 high 194.1 L/h/kg. No mortality or significant signs observed. Biochemical parameters, including liver kidney function markers, remained normal ranges, indicating that well-tolerated. pharmacokinetic profile suggests rapid absorption while assessment indicates good tolerability tested These findings provide foundation for further exploration deZP's therapeutic potential.

Language: Английский

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Origanum syriacum oil-loaded carboxymethyl chitosan polyelectrolyte nanoparticles: Box–Behnken design optimization of nano-encapsulation, physicochemical, and therapeutic properties

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

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Anti-Hyperalgesic Effect of Isopulegol Involves GABA and NMDA Receptors in a Paclitaxel-Induced Neuropathic Pain Model

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 256 - 256

Published: Feb. 14, 2025

Background: Neuropathic pain can be triggered by chemotherapy drugs such as paclitaxel (PTX). Management of is limited drugs' ineffectiveness and adverse effects. Isopulegol (ISO) a monoterpene present in the essential oils several aromatic plants has promising pharmacological activities. Objectives: to evaluate antinociceptive activity ISO PTX-induced neuropathic model. Methods: toxicity was evaluated healthy cancerous cells. Behavioral assessments were performed using von Frey acetone tests. We investigated involvement GABAergic pathway, NMDA, TNF-α, release GABA glutamate presence ISO. Results: showed little or no cytotoxicity U87 MDA-MB-231 In both acute subacute treatment, at doses 25, 50, 100 mg/kg (* p < 0.05) increased mechanical nociceptive threshold animals compared control group reduced thermal sensitivity. Its action reversed pre-treatment with flumazenil potentiated NMDA antagonist, MK-801. TNF-α levels tests carried out. Conclusions: shows low neuronal cells its association PTX generated synergism cytotoxic action. The effect due activation antagonism receptors involves stabilization plasma membranes leading an imbalance neurotransmitters, favoring GABA-mediated inhibition over glutamatergic excitation.

Language: Английский

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Changes in volatile flavor compounds and metabolites during processing of ginger milk curd from buffalo milk by GC-IMS and LC-MS

Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116230 - 116230

Published: March 17, 2025

Language: Английский

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An Overview of the Chemical Compositions and Biological Activities of Essential Oils from Selected Zingiber Species (Zingiberaceae)

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(3)

Published: March 1, 2025

Zingiber Mill. is the second-largest genus of Zingiberaceae family. The members this are known for their diverse applications in food, cosmetics, pharmaceuticals, and healthcare fields due to richness bioactive components found essential oils (EOs). This study aims provide information about EOs’ chemical composition biological activities from 23 species. A literature survey was performed via scientific databases, including PubMed, Scopus, Web Science, Google Scholar, ethnobotanical textbooks. Clustering analysis conducted using Unweighted Pair Group Method with Arithmetic Mean (UPGMA) construct phylogenetic trees. Various studies have revealed that β -pinene, α -caryophyllene, -elemene, bicyclogermacrene, sabinene, camphene, linalool, ( E )-nerolidol, terpinen-4-ol, 1,8-cineole, humulane-1,6-dien-3-ol, -phellandrene, zerumbone representative ingredients EOs. Pharmacologically, current results recorded several species related antioxidant Z. plicatum ), antimicrobial rubens , castaneum nitens tamii magang densissimum cornubracteatum nudicarpum ottensii recurvatum vuquangense eberhardtii skornickovae anti-larvicidal mekongense neotruncatum collinsii antidiabetic atroporphyreus anticancer cytotoxic ) properties. Cluster showed had highest phytochemical similarity, followed by . Additionally, dendrogram offers crucial insights into relationships among species, highlighting similarities between leaves, stems, rhizomes, roots, inflorescences, fruits. first report highlight recent bioactivity assessments summarize EO different parts promising modern medicine.

Language: Английский

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Biological Activities of Essential Oils and Hydrolates from Different Parts of Croatian Sea Fennel (Crithmum maritimum L.)

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 666 - 666

Published: May 4, 2025

The traditional nutritional use of sea fennel (Crithmum maritimum L.) has been rediscovered and reestablished, making this halophyte plant a prominent ingredient in coastal cuisine subject interest various scientific disciplines, including pharmacy medicine. first objective study was to identify the volatile profiles essential oils (EOs) hydrolates derived from leaves, flowers, fruits using gas chromatography–mass spectrometry. A total 25 different volatiles were identified EOs 63 hydrolates. Limonene most abundant component (74.85%, 74.30%, 67.41%, respectively), while hydrolates, it terpinen-4-ol leaves (27.8%) flowers (36.7%) (Z)-carveol (11.4%). second investigate biological activities samples. antioxidant choline inhibitory generally low, with flower hydrolate providing inhibition both enzymes leaf highest antiradical activity. cytotoxic also investigated. human breast adenocarcinoma cell line MDA-MB-23 sensitive against fruits, reaching IC50 after 48 72 h, respectively. exhibited activity effective h. MCF-7 fruit EOs, reached at all tested periods. Overall, results highlight as rich source bioactive compounds that have significant potential for greater utilization nutraceutical pharmaceutical industries.

Language: Английский

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Improving Ancha tea aroma quality via innovative processing: Characterization of key odorants by GC–MS, GC-O, Sensomics, and Chemometrics

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144681 - 144681

Published: May 1, 2025

Language: Английский

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Antistress Effects of Terpinen-4-ol and Compounds of Mimicked Yuzu Synthetic Fragrance in Humans and Mice

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3051 - 3051

Published: Sept. 25, 2024

This study investigated the antistress effects of yuzu synthetic fragrances by employing three experiments on humans and mice using two five single compounds. We prepared based component analysis natural essential oils extracted cold-pressed steam-distilled extraction methods. Chromogranin A (CgA) heart rate (HR) were used as stress indices in human experiments. Immobility time during forced swim test was a index analyzed brain mechanisms measuring expression neurotrophic factors, brain-derived factor (BDNF), nerve growth (NGF), neurotrophin-3 (NT-3) Synthetic fragrance mimicked oil (SD) significantly reduced participants’ experiment 1. In conducted 2, SD immobility time, increased factors BDNF, NGF, NT-3 hippocampus mice. 3, focusing compounds, terpinen-4-ol test. These findings indicate that inhalation has effects. Terpinen-4-ol is strong candidate for further investigation potential stress-reducing agent.

Language: Английский

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