Journal of Drug Delivery and Therapeutics,
Journal Year:
2025,
Volume and Issue:
15(4), P. 126 - 132
Published: April 15, 2025
Medicinal
plants
are
an
integral
part
of
the
healthcare
system
in
Africa.
In
traditional
medicine,
a
mixture
Ipomoea
batatas
leaves
and
Milicia
excelsa
roots
is
used
to
treat
cancer,
mostly
breast
colon
cancer.
It
can
be
on
its
own
or
with
other
common
cancer
treatments.
While
popular
belief
assumes
that
medicinal
plants,
being
natural,
healthier
than
conventional
medicines,
scientific
studies
have
shown
induce
serious
adverse
effects
influence
patient's
prognosis.
order
regulate
use,
literature
review
information
available
composition,
toxicity
anti-cancer
properties
decoction
was
carried
out
December
2024.
To
date,
there
no
publications
anticancer
activity
extracts
roots.
However,
excelsa,
taken
separately,
very
rich
secondary
metabolites
which
been
effective
against
several
types
terms
toxicity,
best
tolerated
at
doses
10
100
mg/kg.
The
not
subject
repeated-dose
studies.
This
revealed
lack
data,
particularly
safety,
prevented
formulation
recommendations
concerning
use.
find
more
about
safety
effectiveness
using
research
needs
done.
Keywords:
Anticancer
activity,
batatas,
excelsa.
Postępy Higieny i Medycyny Doświadczalnej,
Journal Year:
2025,
Volume and Issue:
79(1), P. 16 - 24
Published: Jan. 1, 2025
Abstract
Introduction
Cancer
is
the
main
cause
of
mortality
worldwide,
and
finding
effective
treatments
with
fewer
side
effects
crucial.
Medicinal
plants
offer
significant
potential
in
this
area.
They
contain
bioactive
compounds
that
may
have
antitumor
effects.
The
aim
study
to
assess
cytotoxicity
various
medicinal
towards
several
cancer
cell
lines.
Materials
Methods
Antiproliferative
activity
extracts
from
Crataegus
monogyna
,
Rhamnus
alaternus
Lavandula
dentata
Aristolochia
baetica
Erica
arborea
Cistus
lanifedus
on
lines:
A-498
(kidney
carcinoma),
HepG2
(hepatocellular
PLC/PRF/5
(hepatoma),
MDA-MB-231
(breast
adenocarcinoma),
MV-4-11
(biphenotypic
B
myelomonocytic
leukemia),
one
non-tumorigenic
murine
fibroblast
BALB/3T3
by
colorimetric
methods
using
Sulforhodamine
(SRB)
tetrazolium
salt
(MTT),
enzyme
caspases
3/7
activity,
cycle
analysis
flow
cytometry.
Statistical
was
performed
Shapiro–Wilk
Brown–Forsythe
tests
ensured
normality
variance
equality,
respectively,
followed
one-way
ANOVA
(Dunnett’s
Tukey’s
tests)
for
caspase
two-way
test)
analysis.
Results
(
Aristolochiaceae
)
Lamiacea
e)
antiproliferative
properties
3/7-independent
which
implies
induces
death
through
non-apoptotic
mechanisms.
Extracts
lavender
aristolochia
exhibit
disrupting
progression,
leading
accumulation
dead
cells
sub-G1
phase.
Conclusion
These
two
species
show
promising
therapeutic
as
agents,
operating
mechanisms
distinct
those
conventional
chemotherapeutic
agents.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 453 - 453
Published: March 24, 2025
Background/Objectives:
This
study
presents
a
novel
and
comprehensive
investigation
into
the
anti-colorectal
cancer
(CRC)
effects
underlying
mechanisms
of
Eruca
sativa
(E.
sativa)
using
an
integrated
approach
combining
network
pharmacology,
molecular
docking
dynamics
simulation.
Methods:
Using
approach,
six
bioactive
compounds
40
potential
targets
were
identified.
A
compound–target
was
constructed,
enrichment
analysis
performed
to
explore
key
pathways
influenced
by
E.
sativa.
Molecular
used
evaluate
binding
interactions
between
identified
CRC-related
(AKT1,
PGR,
MMP9,
PTGS2).
Furthermore,
simulation
utilized
confirm
stability
reliability
these
interactions.
Results:
The
found
that
exhibits
strong
anticancer
potential,
particularly
through
major
such
as
β-ionone,
1-octanol,
isorhamnetin,
2-hexenal,
propionic
acid,
quercetin.
revealed
favorable
CRC
targets,
with
quercetin
isorhamnetin
showing
highest
affinities.
Additionally,
simulations
validated
interactions,
reinforcing
their
therapeutic
relevance.
Conclusions:
provides
valuable
insights
pharmacological
against
CRC,
highlighting
its
natural
agent.
These
findings
pave
way
for
future
clinical
studies
validate
efficacy
safety
compounds,
potentially
contributing
development
novel,
plant-based
strategies
treatment.
Kazan medical journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Malignant
neoplasms
remain
one
of
the
leading
causes
mortality
worldwide,
underscoring
need
for
development
novel
and
effective
therapeutic
strategies
their
treatment.
In
recent
years,
scientific
community
has
actively
pursued
search
pharmaceutical
preparations
with
minimal
adverse
effects
high
efficacy,
capable
achieving
complete
remission
in
patients.
this
context,
berberine,
a
natural
phytochemical
compound
derived
from
various
species
Berberis,
garnered
increasing
attention
due
to
its
diverse
pharmacological
properties.
Berberine,
recognized
as
nutraceutical,
exhibits
broad
spectrum
biological
activities,
including
anti-inflammatory,
antioxidant,
antitumor
effects.
vitro
vivo
studies
have
demonstrated
that
berberine
exerts
inhibitory
on
several
types
cancer,
breast,
lung,
liver,
colorectal
cancers.
Its
properties
are
associated
key
molecular
mechanisms
through
which
it
targets
tumor
cells.
review,
we
comprehensively
examined
pathways
mediated.
Specifically,
activates
caspase
cascade,
induction
apoptosis
cells,
inhibits
cell
proliferation
by
blocking
signaling
such
PI3K/Akt/mTOR.
Additionally,
modulates
expression
genes
migration
invasion,
matrix
metalloproteinases
E-cadherin,
making
promising
candidate
approaches.
It
is
also
noteworthy
anti-inflammatory
properties,
may
contribute
prevention
carcinogenesis
protecting
cells
oxidative
stress
inflammatory
processes
linked
cancer
development.
These
position
agent
further
research
clinical
application,
both
monotherapy
combination
other
anticancer
drugs.
Thus,
represents
an
intriguing
subject
investigation
action
potential
use
oncology,
could
lead
more
safer
patients
malignant
neoplasms.
Journal of Drug Delivery and Therapeutics,
Journal Year:
2025,
Volume and Issue:
15(4), P. 126 - 132
Published: April 15, 2025
Medicinal
plants
are
an
integral
part
of
the
healthcare
system
in
Africa.
In
traditional
medicine,
a
mixture
Ipomoea
batatas
leaves
and
Milicia
excelsa
roots
is
used
to
treat
cancer,
mostly
breast
colon
cancer.
It
can
be
on
its
own
or
with
other
common
cancer
treatments.
While
popular
belief
assumes
that
medicinal
plants,
being
natural,
healthier
than
conventional
medicines,
scientific
studies
have
shown
induce
serious
adverse
effects
influence
patient's
prognosis.
order
regulate
use,
literature
review
information
available
composition,
toxicity
anti-cancer
properties
decoction
was
carried
out
December
2024.
To
date,
there
no
publications
anticancer
activity
extracts
roots.
However,
excelsa,
taken
separately,
very
rich
secondary
metabolites
which
been
effective
against
several
types
terms
toxicity,
best
tolerated
at
doses
10
100
mg/kg.
The
not
subject
repeated-dose
studies.
This
revealed
lack
data,
particularly
safety,
prevented
formulation
recommendations
concerning
use.
find
more
about
safety
effectiveness
using
research
needs
done.
Keywords:
Anticancer
activity,
batatas,
excelsa.
