Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies DOI Creative Commons
Md. Sakib Al Hasan, Mohd Shahnawaz Khan, Ayub Ali

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)

Published: May 1, 2025

ABSTRACT Introduction Tangeretin (TAN), a polymethoxylated flavone from citrus peels, exhibits neuroprotective, anti‐inflammatory, and antioxidant properties. This study aims to evaluate the memory‐enhancing effects of TAN in Swiss mice explore its potential molecular interactions with D 2 dopamine (DOP) receptor through vivo behavioral assessments silico approaches. Methods were administered (10 20 mg/kg), DOP (22 olanzapine (OLN) (2 alone combinations per orally (p.o.), followed by cognitive using marble burying, dust removal, trained swimming tests. In studies included docking against (PDB: 6CM4), pharmacokinetics (SwissADME, pkCSM), toxicity predictions (ProTox‐3). Results significantly ( p < 0.05) improved functions, including memory, anxiety, motor coordination, dose‐dependent manner, mg/kg showing most notable effect. The combination TAN‐10 DOP‐22 enhanced these benefits, whereas OLN‐2 reduced improvements. TAN‐treated showed better performance tests, indicating problem‐solving, coordination. These results suggest TAN's enhancement, particularly DOP‐22. No deaths observed any treatment group, all treated animals exhibited normal physiological activity no signs acute toxicity. revealed that strongest binding affinity (BA) (−6.6 kcal/mol) receptor, forming multiple hydrogen bonds (HBs), which indicates mechanism for memory enhancement via dopaminergic modulation. Pharmacokinetic analyses also has favorable ADMET properties, high gastrointestinal absorption, blood–brain barrier penetration, low Conclusion findings highlight as promising therapeutic candidate memory‐related disorders, warranting further clinical exploration.

Language: Английский

Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies DOI Creative Commons
Md. Sakib Al Hasan, Mohd Shahnawaz Khan, Ayub Ali

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)

Published: May 1, 2025

ABSTRACT Introduction Tangeretin (TAN), a polymethoxylated flavone from citrus peels, exhibits neuroprotective, anti‐inflammatory, and antioxidant properties. This study aims to evaluate the memory‐enhancing effects of TAN in Swiss mice explore its potential molecular interactions with D 2 dopamine (DOP) receptor through vivo behavioral assessments silico approaches. Methods were administered (10 20 mg/kg), DOP (22 olanzapine (OLN) (2 alone combinations per orally (p.o.), followed by cognitive using marble burying, dust removal, trained swimming tests. In studies included docking against (PDB: 6CM4), pharmacokinetics (SwissADME, pkCSM), toxicity predictions (ProTox‐3). Results significantly ( p < 0.05) improved functions, including memory, anxiety, motor coordination, dose‐dependent manner, mg/kg showing most notable effect. The combination TAN‐10 DOP‐22 enhanced these benefits, whereas OLN‐2 reduced improvements. TAN‐treated showed better performance tests, indicating problem‐solving, coordination. These results suggest TAN's enhancement, particularly DOP‐22. No deaths observed any treatment group, all treated animals exhibited normal physiological activity no signs acute toxicity. revealed that strongest binding affinity (BA) (−6.6 kcal/mol) receptor, forming multiple hydrogen bonds (HBs), which indicates mechanism for memory enhancement via dopaminergic modulation. Pharmacokinetic analyses also has favorable ADMET properties, high gastrointestinal absorption, blood–brain barrier penetration, low Conclusion findings highlight as promising therapeutic candidate memory‐related disorders, warranting further clinical exploration.

Language: Английский

Citations

0