Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

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Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

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Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 15, 2024

Abstract Nutraceutical interventions supporting microbiota and eliciting clinical improvements in metabolic diseases have grown significantly. Chronic stress, gut dysbiosis, metainflammation emerged as key factors intertwined with sleep disorders, consequently exacerbating the decline quality of life. This study aimed to assess effects two nutraceutical formulations containing prebiotics (fructooligosaccharides (FOS), galactooligosaccharides (GOS), yeast β-glucans), minerals (Mg, Se, Zn), herbal medicine Silybum marianum L. Gaertn., Asteraceae (Milk thistle or Silymarin). These formulations, namely NSupple (without silymarin) NSupple_ (with were tested over 180 days overweight/obese volunteers from Brazil's southeastern region. We accessed fecal by partial 16S rRNA sequences; cytokines expression CBA; anthropometrics, life sleep, well hormonal parameters, at baseline (T0) (T180) post-supplementation. Results demonstrated reshaping phyla, genera, species level The Bacteroidetes phylum, Bacteroides , Prevotella genera positively modulated especially group. Gut modulation was associated improved patterns, quality-of-life perception, expression, anthropometric parameters Our findings suggest that blends enhance cardiometabolic inflammatory markers. Particularly, composition, underscoring its potential significance ameliorating dysregulation. Clinical trial registry number: NCT04810572. 23/03/2021.

Language: Английский

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Effect of anthocyanins on the in vitro fermentation of high-amylose starch

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123271 - 123271

Published: Jan. 14, 2025

Language: Английский

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Deciphering Microbial Carbohydrate Metabolism: Unveiling Mechanistic Insights Into Type 2 Diabetes

Advanced Gut & Microbiome Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The human gut, comprising the stomach, intestine, and colon, hosts a diverse host‐specific microbial community known as gut microbiota. symbiotic relationship between humans their microbiota is highly conserved has evolved over time, playing crucial role in maintaining overall health well‐being. Metagenomic metabolomic analyses have revealed pivotal of regulating body homeostasis, influencing various physiological processes ranging from metabolism to immune system. Several studies demonstrated that dysbiosis associated with severe clinical conditions, including Type 2 diabetes. Individuals diabetes exhibit distinct composition, characterized by reduced diversity an altered relative abundance certain bacterial species. This can result chronic low‐grade inflammation metabolic endotoxemia. also marked persistent inflammation, where inflammatory cytokines contribute impaired glucose insulin resistance. complex, necessitating further research elucidate underlying mechanisms develop effective therapies. review provides valuable insights into potential aspects diabetes, metabolism, resistance, inflammation. aim this article highlight importance therapeutic target for managing

Language: Английский

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Therapeutic Prospects of Undaria pinnatifida Polysaccharides: Extraction, Purification, and Functional Activity

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 163 - 163

Published: April 8, 2025

Undaria pinnatifida, an edible brown seaweed that is widely consumed in East Asia, has gained increasing recognition for its health benefits. Among bioactive compounds, polysaccharides have attracted significant attention due to their diverse biological activity. This review provides a comprehensive overview of recent advancements the extraction, purification, structural characterization, and bioactivity U. pinnatifida polysaccharides. We discuss state-of-the-art extraction techniques, including ultrasound-assisted, microwave-assisted, enzyme-assisted as well purification strategies such membrane separation chromatographic methods. Furthermore, we highlight potential activity, antioxidant, immunomodulatory, anticancer, gut health-promoting, anti-hyperglycemic effects, along with underlying mechanisms action. By summarizing latest research, this aims provide valuable insights into development application functional foods pharmaceuticals.

Language: Английский

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Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 16, 2025

Abstract Background Pancreatic cancer (PC) presents a significant challenge in oncology because of its late-stage diagnosis and limited treatment options. The inadequacy current screening methods has prompted investigations into stool-based assays microbial classifiers as potential early detection markers. gut microbiota composition PC patients may be influenced by population differences, thereby impacting the accuracy disease prediction. However, comprehensive profiling analysis these cofactors remain limited. Therefore, we analyzed stool 33 Finnish 50 Iranian along with 35 34 healthy controls using 16S rRNA gene sequencing. We assessed similarities differences both populations while considering sociocultural impacts generated statistical model for prediction based on classifiers. Our aim was to expand understanding microbiota, discuss impact contribute development through biomarkers. Results Compared controls, presented reduced diversity, discernible profiles factors such ethnicity, demographics, lifestyle. marked significantly higher abundances facultative pathogens including Enterobacteriaceae, Enterococcaceae, Fusobacteriaceae, lower beneficial bacteria. In particular, bacteria belonging Clostridia class, butyrate-producing Lachnospiraceae, Butyricicoccaceae, Ruminococcaceae, were depleted. A classifier pancreatic ductal adenocarcinoma (PDAC) developed cohort evaluated cohort, where it yielded respectable AUC 0.88 (95% CI 0.78, 0.97). Conclusions This study highlights microbes biomarkers noninvasive targeted therapies, emphasizing need further research validate findings diverse populations. role microbiome could enhance efforts improve patient outcomes.

Language: Английский

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The composition, internal interactions, auxiliary preparation methods, and applications of type five resistant starch: A review

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 160, P. 110835 - 110835

Published: Nov. 12, 2024

Language: Английский

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Review of the Relationships Between Human Gut Microbiome, Diet, and Obesity

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 3996 - 3996

Published: Nov. 22, 2024

Obesity is a complex disease that increases the risk of other pathologies. Its prevention and long-term weight loss maintenance are problematic. Gut microbiome considered potential obesity modulator. The objective present study was to summarize recent findings regarding relationships between obesity, gut microbiota, diet (vegetable/animal proteins, high-fat diets, restriction carbohydrates), with an emphasis on dietary fiber resistant starch. composition human methods its quantification described. Products metabolism, such as short-chain fatty acids secondary bile acids, their effects intestinal barrier function immune homeostasis discussed in context obesity. importance starch emphasized far host concerned. finally summarized.

Language: Английский

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A comprehensive study of liver-gut microbiota and antioxidant enzyme activity mediated regulation of late-laying hens by high and low residual feed intake

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 139938 - 139938

Published: Jan. 15, 2025

Language: Английский

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