Journal of the American Oil Chemists Society,
Journal Year:
2023,
Volume and Issue:
101(11), P. 1127 - 1132
Published: Nov. 10, 2023
Abstract
Branched‐chain
fatty
acids
(BCFAs)
have
recently
gained
increasing
attention
as
bioactive
lipids
with
potential
nutritional
properties
and
a
wide
array
of
applications
in
human
health.
The
current
study
reviews
the
most
recent
progress
BCFA
preparation.
An
overview
extraction
from
natural
sources,
including
lanolin
butter,
is
provided.
Further,
we
explore
how
clay
catalysts
zeolites
can
be
used
to
chemically
synthesize
BCFAs.
synthetic
BCFAs
are
mainly
isostearic
acids.
Some
bacterial
membranes
contain
high
proportion
been
studied
raw
materials
obtain
Engineering
microbial
production
also
reviewed.
Special
attentions
given
molecular
structure
during
different
preparation
methods.
Future
research
will
focus
on
obtaining
specific
structures
purity.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
In
this
study,
we
investigated
the
effects
of
infant
fecal
fermentation-derived
metabolites
digested
osteopontin
(OPN)
and
2′-fucosyllactose
(2′-FL),
either
individually
or
in
combination,
on
intestinal
barrier
function
using
a
Caco-2/HT-29
coculture
cell
model.
Our
results
suggested
that
OPN/2′-FL
(1:36–1:3)
cofermentation
improved
epithelial
integrity
by
supporting
mRNA
protein
expression
occludin,
claudin-1,
claudin-2,
ZO-1,
ZO-2.
All
treatments
decreased
production
IL-1β,
IL-6,
TNF-α,
while
ratio
increased
IL-10
inhibiting
activation
MyD88/IκB-α/NF-κB
signaling
pathway.
altered
metabolic
pathways,
protective
effect
fermentation
was
related
to
differential
metabolite
such
as
short-chain
fatty
acids,
deoxycholic
acid,
4-aminobutyric
acid.
findings
provide
vitro
evidence
support
application
combination
formula
for
advancement
formulation
functionality,
including
function.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(17)
Published: Feb. 23, 2024
Abstract
Veillonella
parvula
,
prototypical
member
of
the
oral
and
gut
microbiota,
is
at
times
commensal
yet
also
potentially
pathogenic.
The
definition
molecular
basis
tailoring
this
contrasting
behavior
key
for
broadening
our
understanding
microbiota‐driven
pathogenic
and/or
tolerogenic
mechanisms
that
take
place
within
body.
In
study,
we
focused
on
chemistry
main
constituent
outer
membrane
V.
lipopolysaccharide
(LPS).
LPS
molecules
indeed
elicit
pro‐inflammatory
immunomodulatory
responses
depending
their
chemical
structures.
Herein
report
structural
elucidation
from
two
strains
show
important
unprecedented
differences
in
both
lipid
carbohydrate
moieties,
including
identification
a
novel
galactofuranose
mannitol‐containing
O‐antigen
repeating
unit
one
strains.
Furthermore,
by
harnessing
computational
studies,
vitro
human
cell
models,
as
well
lectin
binding
solid‐phase
assays,
discovered
chemically
diverse
immunologically
behave
differently
have
attempted
to
identify
determinant(s)
governing
phenomenon.
Whereas
potential
has
been
evidenced
A
moiety,
contrast
plausible
“immune
modulating”
action
proposed
peculiar
portion.
European Journal of Lipid Science and Technology,
Journal Year:
2024,
Volume and Issue:
126(10)
Published: Aug. 27, 2024
Abstract
Branched‐chain
fatty
acids
(BCFAs)
are
mostly
saturated
with
a
methyl
branch
at
the
penultimate
or
antepenultimate
position
to
CH
3
end.
Very‐long‐chain
BCFAs
(C
≥
20)
uniquely
found
in
surface
lipids.
Human
and
California
sea
lion
(
Zalophus
californianus
)
only
two
species
that
possess
vernix
birth,
particles
carry
loads
of
BCFA
gut,
potentially
influencing
establishment
first
microbiota.
Horse
Equus
caballus
contains
high
levels
its
lipids,
current
study
aims
investigate
if
components
neonatal
foal's
gut.
Electron
ionization
tandem
mass
spectrometry
was
used
distinguish
iso
‐
anteiso
‐form
from
straight‐chain
acids.
Abundant
very‐long‐chain
‐BCFA,
mainly
even‐numbered
‐20:0,
‐22:0,
‐24:0,
‐26:0
were
horse
meconium
but
not
their
manure
collected
few
months
later.
There
little
differences
types
concentrations
between
foal
adult
manure.
Moderate
‐BCFA
also
found.
Comparisons
skin
cholesterol
ester
content
human
suggest
derived
origin.
The
expands
our
knowledge
on
gut
nutritional
environment
newborn
horse,
further
is
needed
establish
relationship
microbiota
composition
hours
life.
Practical
Applications
:
(BCFA)
bioactive
compounds
caseosa,
lipid‐laden
material
covering
baby.
reaches
third
trimester
gestation
until
birth.
However,
exact
functionality
mechanisms
fetus
remain
unclear.
clarify
lipid
conditions
foals
identify
associations
critical
point
when
horse's
establishes
itself.
findings
lay
path
for
studying
physiological
functions
models,
accelerating
research
related
BCFA.
BMC Genomics,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 31, 2024
This
study
aimed
to
investigate
the
temporal
accumulation
of
odor
fatty
acids
(OFAs)
in
dorsal
subcutaneous
adipose
tissue,
and
uncover
their
dynamic
regulatory
metabolic
pathways
from
transcriptomic
perspective
lambs
birth
market.
Thirty-two
Hulun
Buir
were
selected
randomly
assigned
four
different
sampling
stages
following
growth
trajectories:
neonatal
(day
1),
weaning
75),
mid-fattening
150),
late-fattening
180)
stages.
Results
indicated
that
contents
three
OFAs
increased
progressively
as
matured,
with
most
drastic
change
occurred
at
vs.
weaning.
The
profiles
exhibited
two
distinct
phases,
differentially
expressed
genes
(DEGs)
before
involved
immune
homeostasis,
whereas
those
after
associated
nutrient
metabolism.
Furthermore,
DEGs
lipid
metabolism
branch-chain
amino
acid
degradation
surge
expression
weaning,
acetyl-CoA
branched-chain-CoA
intermediates,
driven
by
regulation
PPAR
AMPK
signaling
pathways.
Overall,
our
findings
provided
novel
insight
into
critical
time
window
pivotal
candidate
OFA
synthesis
which
will
assist
targeted
development
nutritional
strategies
inhibit
lambs.
Journal of the American Oil Chemists Society,
Journal Year:
2023,
Volume and Issue:
101(11), P. 1127 - 1132
Published: Nov. 10, 2023
Abstract
Branched‐chain
fatty
acids
(BCFAs)
have
recently
gained
increasing
attention
as
bioactive
lipids
with
potential
nutritional
properties
and
a
wide
array
of
applications
in
human
health.
The
current
study
reviews
the
most
recent
progress
BCFA
preparation.
An
overview
extraction
from
natural
sources,
including
lanolin
butter,
is
provided.
Further,
we
explore
how
clay
catalysts
zeolites
can
be
used
to
chemically
synthesize
BCFAs.
synthetic
BCFAs
are
mainly
isostearic
acids.
Some
bacterial
membranes
contain
high
proportion
been
studied
raw
materials
obtain
Engineering
microbial
production
also
reviewed.
Special
attentions
given
molecular
structure
during
different
preparation
methods.
Future
research
will
focus
on
obtaining
specific
structures
purity.
