Silk Fibroin-Based Lenvatinib Nanomedicine with Conformation Tunability for Systemic Treatment of Hepatocellular Carcinoma DOI
Kaxi Yu, Yu Wang, Hongxiang Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60070 - 60083

Published: Oct. 22, 2024

Multitarget tyrosine kinase inhibitors (TKIs) serve as first-line therapeutics in the systemic treatment of hepatocellular carcinoma (HCC), yet their clinical effectiveness is hampered by suboptimal pharmacokinetics and bioavailability. There a critical need to enhance circulation, tumor targeting, infiltration TKIs. In this context, we developed silk fibroin (SF)-based nanomedicine that exploits chemical versatility conformation tunability SF. Folic acid (FA) with affinity toward HCC cells utilized functionalize SF, simultaneously aiding pH-sensitive β-sheet transitions This dynamic behavior key improving nanomedicine's biological adhesion, localization. By encapsulating Lenvatinib (Leva) TKI, exhibits tumor-targeted accumulation potent inhibition on cell survival angiogenesis, thereby amplifying Leva's bioavailability therapeutic impact. Owing SF's low immunogenicity high reproducibility, SF-based approach for TKI delivery holds substantial promise advancing therapy.

Language: Английский

Fabrication of Silk Fibroin‐Derived Fibrous Scaffold for Biomedical Frontiers DOI Creative Commons
Mustafijur Rahman, Tanvir Mahady Dip, Md. Golam Nur

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(5)

Published: March 12, 2024

Abstract Silk fibroin (SF), a natural protein derived from silkworms, has emerged as promising biomaterial due to its biocompatibility, biodegradability, degradation rate, and tunable mechanical properties. This review delves into the intrinsic attributes of SF that make it an attractive candidate for scaffold development in tissue engineering regenerative medicine. The distinctiveness this comprehensive resides detailed exploration recent advancements fabrication techniques SF‐based fibrous scaffolds, namely electrospinning, freeze‐drying, 3D printing. An in‐depth analysis these is conducted illustrate their versatility customizing essential characteristics, such porosity, fiber diameter, strength. article meticulously discusses process parameters, advantages, challenges each technique, highlighting innovative made respective field. Furthermore, goes beyond provide overview latest biomedical applications research endeavors utilizing SF‐derived scaffolds. From nerve regeneration wound healing drug delivery, bone regeneration, vascular engineering, diverse underscore adopting various challenges. Finally, emphasizes need standardized characterization techniques, scalable manufacturing processes, long‐term vivo studies.

Language: Английский

Citations

10
Silk fibroin for cosmetic dermatology DOI
Songjie Li, Han Chen,

Xin Dan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159986 - 159986

Published: Jan. 1, 2025

Citations

1
Mechanical Properties and Decomposition Behavior of Compression Moldable Poly(Malic Acid)/α-Tricalcium Phosphate Hybrid Materials DOI Open Access
Shuta Hara, Akiko Kojima, Atsushi Furukawa

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 147 - 147

Published: Jan. 9, 2025

Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances regenerative medicine have increased the demand materials to assist regenerating these tissues. Among various forms of calcium phosphate (CaP), tricalcium (TCP)-particularly its α-TCP form-stands out due high solubility efficient release, making it a promising candidate bone regeneration applications. Nevertheless, rapid dissolution rate presents challenges when used reinforcing agent. In this study, we developed hybrid material composed poly(malic acid) (PMA) achieve controlled release while maintaining mechanical strength. The were prepared using compression molding method optimized suppress hydrolysis PMA. bond between carboxyl group PMA was confirmed through infrared (IR) spectroscopy. A test demonstrated that interaction extends period both components. These findings indicate PMA/α-TCP significant potential applications tissue engineering.

Language: Английский

Citations

0
Protein-based Materials: Applications, Modification and Molecular Design DOI Creative Commons

Alitenai Tunuh,

Ze Zheng,

Xinran Rao

et al.

BioDesign Research, Journal Year: 2025, Volume and Issue: unknown, P. 100004 - 100004

Published: Feb. 1, 2025

Language: Английский

Citations

0
Self-reinforced silk nanofibrils networks enable ultrafine fibroin monofilament sutures applied in minimally invasive surgery DOI
Xin Zhang,

Xin Yang,

Zhenbei Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142941 - 142941

Published: April 1, 2025

Language: Английский

Citations

0
Multifunctional applications of silk fibroin in biomedical engineering: A comprehensive review on innovations and impact DOI
Yunan Lin, Lifen Zhao, Hairong Jin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 143067 - 143067

Published: April 11, 2025

Language: Английский

Citations

0
Advances in 3D printing for the repair of tympanic membrane perforation: a comprehensive review DOI Creative Commons
Hao Xue,

Shengjia Chen,

Yi Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 12, 2024

Tympanic membrane perforation (TMP) is one of the most common conditions in otolaryngology worldwide, and hearing damage caused by inadequate or prolonged healing can be distressing for patients. This article examines rationale utilizing three-dimensional (3D) printing to produce scaffolds repairing TMP, compares advantages disadvantages 3D printed bioprinted grafts with traditional autologous materials other tissue engineering TMP repair, highlights practical clinical significance repair while discussing current progress promising future bioprinting. There a limited number reviews specifically dedicated repair. The majority offer general overview applications broader realm regeneration, some mention Alternatively, they explore biopolymers, cells, drug molecules utilized However, more in-depth analysis needed on strategies selecting bio-inks that integrate tympanic

Language: Английский

Citations

1
Encapsulating Biosurfactants in Biopolymers for Innovative Applications in the Food Industry DOI Creative Commons
Niumaique Gonçalves da Silva, Franciely Grose Colodi, Mayka Reghiany Pedrão

et al.

ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: 4(11), P. 2528 - 2549

Published: Oct. 25, 2024

Biosurfactants are surface-active molecules produced by yeasts, fungi, and bacteria under different fermentation conditions growing substrates. These considered safe for human health have emulsifying properties that improve the palatability, nutritional content, quality of food products. In this Review, potential applications biosurfactants encapsulated in natural polymers industry explored. with from sources can exhibit synergistic characteristics, increasing their physicochemical biological action. addition, offer viable alternatives to replace preservatives synthetic chemical surfactants, which widely used industry.

Language: Английский

Citations

1
Ultrasonication-Induced Preparation of High-Mechanical-Strength Microneedles Using Stable Silk Fibroin DOI Open Access

Huihui Liang,

Jiaxin Chen,

Guirong Qiu

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(22), P. 3183 - 3183

Published: Nov. 16, 2024

Silk fibroin (SF) is an ideal material for microneedle (MN) preparation. However, long extraction and short storage durations limit its application. Furthermore, MNs prepared from SF alone are easy to break during skin insertion. In this study, a regenerated solution was autoclaved freeze-dried produce stable water-soluble sponge. The (FD-SF) ultrasonically treated before being used in the fabrication of MNs. modified SFMNs (US-SFMNs) were evaluated comparison FD-SFMNs made FD-SF conventional SF. results indicated that could be completely dissolved water remained even after 8 months storage. FTIR XRD analyses showed US-SFMNs had increased β-sheet content crystallization compared FD-SFMNs, by 7.3% 8.1%, respectively. higher mechanical strength than with fracture force 1.55 N per needle rat insertion depth 370 μm. also demonstrated enhanced transdermal drug delivery enzymatic degradation vitro. conclusion, autoclaving freeze drying SF, as well ultrasonication-induced MN preparation, provide promising SF-based microneedles delivery.

Language: Английский

Citations

1
Silk Fibroin-Based Lenvatinib Nanomedicine with Conformation Tunability for Systemic Treatment of Hepatocellular Carcinoma DOI
Kaxi Yu, Yu Wang, Hongxiang Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60070 - 60083

Published: Oct. 22, 2024

Multitarget tyrosine kinase inhibitors (TKIs) serve as first-line therapeutics in the systemic treatment of hepatocellular carcinoma (HCC), yet their clinical effectiveness is hampered by suboptimal pharmacokinetics and bioavailability. There a critical need to enhance circulation, tumor targeting, infiltration TKIs. In this context, we developed silk fibroin (SF)-based nanomedicine that exploits chemical versatility conformation tunability SF. Folic acid (FA) with affinity toward HCC cells utilized functionalize SF, simultaneously aiding pH-sensitive β-sheet transitions This dynamic behavior key improving nanomedicine's biological adhesion, localization. By encapsulating Lenvatinib (Leva) TKI, exhibits tumor-targeted accumulation potent inhibition on cell survival angiogenesis, thereby amplifying Leva's bioavailability therapeutic impact. Owing SF's low immunogenicity high reproducibility, SF-based approach for TKI delivery holds substantial promise advancing therapy.

Language: Английский

Citations

0