Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105189 - 105189
Published: Sept. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4744 - 4744
Published: April 26, 2024
Cannabidiol (CBD) is a non-psychoactive compound derived from Cannabis sativa. It has demonstrated promising effects in combating inflammation and holds potential as treatment for the progression of chronic inflammation. However, clinical application CBD limited due to its poor solubility bioavailability. This study introduces an effective method preparing CBD-loaded solid lipid nanoparticles (CBD-SLNs) using combination low-energy hot homogenization ultrasonication. We enhanced this process by employing statistical optimization with response surface methodology (RSM). The optimized CBD-SLN formulation utilizes glyceryl monostearate primary component nanocarrier. screened tool managing Stable, uniformly dispersed spherical size 123 nm, charge −32.1 mV, encapsulation efficiency 95.16%, drug loading 2.36% were obtained. CBD-SLNs exhibited sustained release properties, ensuring prolonged controlled delivery, which could potentially amplify therapeutic effects. Additionally, we observed that significantly reduced both reactive oxygen nitrogen species proinflammatory cytokines chondrocyte macrophage cell lines, these inhibitory being more pronounced than those free CBD. In conclusion, superiority over CBD, highlighting delivery system
Language: Английский
Citations
5
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106763 - 106763
Published: Feb. 1, 2025
Language: Английский
Citations
0
Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 973 - 973
Published: March 12, 2025
Lipid nanoparticles (LNs) have emerged as advanced lipid-based delivery systems, offering an effective approach for encapsulating and protecting lipid-soluble bioactive compounds, increasing their bioavailability. Solid Nanoparticles (SLNs) Nanostructured Carriers (NLCs) are particularly promising compound entrapment. However, to fully exploit potential, it is crucial carefully select the appropriate lipid matrices emulsifiers. This review offers a comprehensive, up-to-date examination, considering studies published in last 15 years, of chemical, physical, structural characteristics lipids employed LN production, focusing on key components formulations: matrices, emulsifiers, compounds. In addition, provides in-depth analysis production methods, drawing insights from latest scientific literature, emphasizes most important characterization techniques LNs. Key parameters, including particle size (PS), zeta potential (ZP), crystallinity, thermal behavior, morphology, entrapment efficiency (EE), load capacity (LC), physical stability, discussed. Ultimately, this aims identify critical factors successful stable LNs that efficiently encapsulate deliver highlighting significant applications food systems.
Language: Английский
Citations
0
Food Research International, Journal Year: 2024, Volume and Issue: 188, P. 114498 - 114498
Published: May 10, 2024
The emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid-based nanosystems developed enhance the bioaccessibility cannabidiol (CBD) was investigated. IL (cholinium oleate) evaluated at concentrations 1 % and 2 nanoemulsions (NE-IL) nanostructured lipid carriers (NLC-IL) loaded with CBD. concentration demonstrated be sufficient both NE-IL NLC-IL excellent stability properties, entrapment efficiency superior 99 %, CBD retention rate 100 during storage period (i.e. 28 days 25 °C). in vitro digestion evaluation that provided higher CBD, while improved bioaccessibility, which mainly related composition matrices used obtain each nanosystem. Finally, it observed cytotoxicity reduced when compound entrapped into nanosystems.
Language: Английский
Citations
3
Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105033 - 105033
Published: Sept. 1, 2024
Language: Английский
Citations
3
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 871 - 886
Published: Jan. 1, 2025
This study focuses on the development and evaluation of nanostructured lipid carriers (NLCs) loaded with aloperine as a potential therapeutic approach for treatment pulmonary arterial hypertension. The NLCs were designed to enhance solubility, stability, bioavailability aloperine, compound vasodilatory anti-inflammatory properties. Through series experiments including single-factor experimentation, transmission electron microscopy, high-performance liquid chromatography, in vivo pharmacokinetics, tissue distribution studies, we assessed physicochemical properties, drug release profiles, vitro performance this novel nanocarrier. prepared aloperine-loaded exhibited milky white translucent suspension appearance, presenting quasi-spherical shape under microscope, an average particle size (509.48±30.04) nm entrapment efficiency (64.18±1.14)%. profile demonstrated good sustained-release characteristics vitro, formulation remained stable up 15 days when stored at 4°C. Compared solution group, t1/2, AUC(0→t), AUC(0→∞), MRT(0→t), clearance rate 2.3, 2.96, 3.06, 3.03, 0.22 times higher, respectively. indicates that formulating into can prolong its circulation time body. Furthermore, concentrations lungs group 1.79, 3.78, 2.30 higher than those three points (0.25 h, 1.5 4 h), suggesting increase accumulation lungs. Our findings suggest could offer promising strategy
Language: Английский
Citations
0
Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144193 - 144193
Published: April 1, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2024, Volume and Issue: 9(39), P. 40632 - 40643
Published: Sept. 19, 2024
Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application of CBD is significantly impeded by polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability nanostructured lipid carriers loaded with (CBD-NLCs) were developed using a hot-melt emulsification method optimized response surface methodology (RSM). The process parameters four-factor three-level Box-Behnken experimental design consisting 29 experiments. CBD-NLCs formulated characterized, demonstrating desirable properties, including mean particle size 54.33 nm, PDI value 0.118, zeta -29.7 mV, an impressive encapsulation efficiency rate 87.58%. nanoparticles found possess approximately spherical shape, as revealed scanning transmission electron microscopy. studies have that effectively mitigated photodegradation exhibited stable behavior for 42 days when stored. displayed biphasic release profile characterized initial burst (over 50% released within 20 min) followed subsequent gradual sustained release, aligned first-order kinetics Fickian diffusion. These findings demonstrate suitability this formulation carrier in food fortification pharmaceutical applications.
Language: Английский
Citations
3
Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2464 - 2464
Published: Aug. 4, 2024
The purpose of this work was to construct liver-targeted nanoparticles based on the redox response effectively deliver cannabidiol (CBD) for prevention acute liver injury (ALI). CBD-loaded (CBD NPs) with a particle size 126.5 ± 1.56 nm were prepared using polymer DA-PP-LA obtained by grafting pullulan polysaccharide deoxycholic acid (DA) and α-lipoic (α-LA). CBD NPs showed typical redox-response release behavior. Interestingly, exhibited admirable targeting ability, significantly accumulated in liver, promoted internalization cells, thus reducing H
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105189 - 105189
Published: Sept. 1, 2024
Language: Английский
Citations
1