Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis DOI Creative Commons

Mengqiu Wei,

Ping LYu,

Peng Li

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 6427 - 6446

Published: Dec. 1, 2024

Purpose:The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS).However, the therapeutic effects, primary bioactive ingredients, potential mechanisms underlying AS remain unclear.This study aimed to investigate pharmacological principal active of BLEC against AS.Methods: Adeno-associated virus tail vein injection was utilized construct liver-specific LXRα knockout ApoE -/-mice.A high-fat diet feed -/-mice build hyperlipidemia mouse models.The aorta or liver stained with Oil Red O used assess effect drugs on fatty formation after oral administration BLEC, piperine, statins, ezetimibe mice following experimental protocol.Biochemical assays were evaluate serum lipid levels cholesterol efflux indicators.Transcriptomics employed gene expression levels.HPLC-MS/MS determine its major components in liver.Western blotting quantitative reverse transcription polymerase chain reaction conducted detect LXRα, ABCA1, ABCG5, ABCG8, CYP7A1 expression.Results: Here, we revealed that decreases liver, as well decelerates by promoting excretion.BLEC which are main exposed target tissue, activate upregulate CYP7A1, promotes transport high-density lipoprotein excretion bile feces.Notably, piperines demonstrated synergistic beneficial effects atorvastatin ezetimibe, two widely hypocholesterolemic anti-atherosclerotic drugs.Conclusion: ingredient, promote excretion, reduce levels, inhibit AS, exhibit good clinical application value prospects.

Language: Английский

New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine DOI Creative Commons
Minghui Zhang,

Zongao Wang,

Shaojun Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 11, 2025

Vanilloid1 (TRPV1), a subfamily of transient receptor channels, is one the non-selective calcium which bridge between cellular response and extracellular environmental networks, involved in variety pathophysiological processes. It also process cancer occurrence progression, researchers are revealing its role cancer. In this paper, we review expression significance TRPV1 various cell types, apoptosis-proliferation balance, invasion metastasis, tumor micro-environment, with emphasis on mechanisms by mediates inflammatory response, immune system, thus regulates We discussed latest directions current challenges receptor-targeting therapy for cancer, summarized odorous traditional herbs that modulate receptors, view to developing anti-tumor drugs targeting receptors future.

Language: Английский

Citations

0
Design, Synthesis and Evaluation of Novel 1,3-Benzodioxole Derivatives for Their Anti-Tumor Activity DOI
Jing Ji,

Bing-Yan Wang,

Lu Cheng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Extract of Piper nigrum Improves the Cognitive Impairment and Mood in Sleep-Deprived Mice Through the JAK1/STAT3 Signalling Pathway DOI Open Access

Dongyan Guan,

Zhiying Hou,

Bei Fan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1842 - 1842

Published: Feb. 21, 2025

Piper nigrum L. (PN), which contains various bioactive compounds, is a plant with homologous medicine and food. Sleep deprivation (SD) profoundly impacts cognitive function emotional health. However, the mechanisms by PN improves depressive mood induced SD remain unclear. In our study, network pharmacology molecular docking techniques were used to predict potential regulates SD. this 220 compounds identified in PN, 10 core targets screened through pharmacology. Animal experiments showed that ameliorated deficits sleep-deprived mice, upregulated serum activities of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), downregulated malondialdehyde (MDA) levels. The ELISA assay significantly decreased tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β) Histopathological staining brain tissue demonstrated mitigates SD-induced hippocampal damage, enables hippocampus produce more neurotransmitters, including 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA), dopamine (DA), reduces glutamate (Glu) RT-qPCR WB analyses further indicated could exert anti-SD effects inhibiting over-activation JAK1/STAT3 signalling pathway. PC12 cell model, reduce inflammation prevent apoptosis, exerting neuroprotective effects. summary, has positive on alleviating symptoms dysfunction

Language: Английский

Citations

0
A New Screening Strategy for Flavonoid Components to Obtain a Satisfactory Co-Amorphous System with Piperine. DOI
Jiawei Han, Wen Sun,

Yongxu Yao

et al.

PubMed, Journal Year: 2025, Volume and Issue: 26(3), P. 78 - 78

Published: March 5, 2025

Language: Английский

Citations

0
Piperine Ameliorates diabetic mellitus erectile dysfunction by Reducing Oxidative Stress and Apoptosis Through the PI3K/AKT/NRF2 Signaling Pathway DOI
Zhongkai Guo, Hao Liu,

Danfeng Zhao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106326 - 106326

Published: March 1, 2025

Language: Английский

Citations

0
Evaluation of the phytochemicals and antimicrobial properties of Tetrapleura Tetraptera and Piper Nigrum DOI

Rene Tanwieh Esoh,

Dasi Tchoffo Davila,

Solomon Gyampoh

et al.

Modern journal of health and applied sciences., Journal Year: 2024, Volume and Issue: 1(1), P. 1 - 9

Published: Sept. 15, 2024

The search for new substances with antibacterial activities has become an urgent necessity due to the resistance of many bacteria medical importance antibiotics. In attempt seek out agents from plants, E. coli, S. aureus, and Salmonella spp susceptibility seed extracts Tetrapleura tetraptera Piper nigrum were assessed. A Qualitative phytochemical screening was also done establish various phytochemicals found in plants. To achieve these findings, dried seeds collected Bamenda food market ground. Further, powder obtained subjected aqueous alcoholic extractions separately which teraptera evaluated their potential against using agar diffusion. results indicated that aureus coli susceptible extract (with a MIC 50mg/ml; 100mg/ml) respectively, S.aureus (25mg/ml; 50mg/ml) E.coli. For shows sensitivity 100mg/ml). Complete registered nigrum. Furthermore, presence resins, alkaloids, glycosides, tannins, flavonoids (present all powder), saponins (absent only nigrum). conclusion, activity coli. It proposed further studies should be carried on other bacteria.

Language: Английский

Citations

0
Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis DOI Creative Commons

Mengqiu Wei,

Ping LYu,

Peng Li

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 6427 - 6446

Published: Dec. 1, 2024

Purpose:The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS).However, the therapeutic effects, primary bioactive ingredients, potential mechanisms underlying AS remain unclear.This study aimed to investigate pharmacological principal active of BLEC against AS.Methods: Adeno-associated virus tail vein injection was utilized construct liver-specific LXRα knockout ApoE -/-mice.A high-fat diet feed -/-mice build hyperlipidemia mouse models.The aorta or liver stained with Oil Red O used assess effect drugs on fatty formation after oral administration BLEC, piperine, statins, ezetimibe mice following experimental protocol.Biochemical assays were evaluate serum lipid levels cholesterol efflux indicators.Transcriptomics employed gene expression levels.HPLC-MS/MS determine its major components in liver.Western blotting quantitative reverse transcription polymerase chain reaction conducted detect LXRα, ABCA1, ABCG5, ABCG8, CYP7A1 expression.Results: Here, we revealed that decreases liver, as well decelerates by promoting excretion.BLEC which are main exposed target tissue, activate upregulate CYP7A1, promotes transport high-density lipoprotein excretion bile feces.Notably, piperines demonstrated synergistic beneficial effects atorvastatin ezetimibe, two widely hypocholesterolemic anti-atherosclerotic drugs.Conclusion: ingredient, promote excretion, reduce levels, inhibit AS, exhibit good clinical application value prospects.

Language: Английский

Citations

0