Changes in the Profile of Phenolic Compounds and in the Antioxidant, Hypoglycemic, and Antidiabetic Activities of a Beverage Based on Sesame By-Product Caused by the Simulated Gastrointestinal Digestion Process DOI Creative Commons

Jonhatan Carrasco-Chávez,

María Fernanda Quintero-Soto, Rosalio Velarde-Barraza

et al.

Beverages, Journal Year: 2024, Volume and Issue: 10(4), P. 115 - 115

Published: Nov. 26, 2024

The by-product of extracting oil from sesame has good functional properties for use in the development new food products. In this study, effect simulated gastrointestinal digestion on bioaccessibility phenolic compounds, as well antioxidant, antidiabetic, and hypoglycemic a beverage by-products was analyzed. Oral significantly decreased total content beverage, while flavonoid increased. Both phytochemicals increased after gastric intestinal digestion. Twenty-five compounds were characterized including feruloylquinic acid, which present all digestive fractions most abundant free quercetin, also digested fractions. On other hand, isorhamnetin. During digestion, antioxidant activity inhibitory effects α-glucosidase DPP-IV improved, ability to inhibit α-amylase during oral remaining constant throughout Correlation analysis indicated that flavonoids, may be with greatest evaluated activities. results study not only improve understanding impact but suggest potential applications formulating foods enhanced hypoglycemic, antidiabetic properties, contributing health-promoting

Language: Английский

Boosting the human antiviral response in conjunction with natural plant products DOI Creative Commons
Rashmi Srivastava, Neeraj Kumar Dubey,

Megha Sharma

et al.

Frontiers in Natural Products, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 7, 2025

The increasing prevalence of viral infections and the emergence drug-resistant or mutant strains necessitate exploration novel antiviral strategies. Accumulating evidence suggests that natural plant products have significant potential to enhance human response. Various (PNPs) known for their properties been evaluated ability modulate immune responses inhibit infections. Research has focused on understanding mechanisms by which these PNPs interact with system complement existing therapies. control compounds such as alkaloids, flavonoids, terpenoids, polyphenols promote cytokine synthesis, increase T-cell macrophage activity, activate genes. Studies investigated molecular interactions between PNPs, viruses, host cells, exploring combining conventional drugs efficacy. However, several challenges remain, including identifying, characterizing, standardizing PNP extracts, optimizing dosages, improving bioavailability, assessing long-term safety, navigating regulatory approval. promising is being explored develop new, effective, This review outlines a framework an integrative approach connect full in combating health. By treatments, more effective sustainable management diseases can be achieved.

Language: Английский

Citations

3
Caffeic acid alleviates myocardial ischemia-reperfusion injury by directly targeting Keap1N532/M550 and promoting its degradation DOI Creative Commons

Ying Zhang,

Huan Lan,

Wenjuan Zhai

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101219 - 101219

Published: Jan. 1, 2025

Language: Английский

Citations

0
Chemical Variation of Leaves and Pseudobulbs in Prosthechea karwinskii (Orchidaceae) in Oaxaca, Mexico DOI Creative Commons
Gabriela Soledad Barragán-Zarate, B. López, Manuel Cuéllar-Martínez

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(4), P. 608 - 608

Published: Feb. 18, 2025

Prosthechea karwinskii is an endemic orchid of Mexico with significant value for its traditional uses: ornamental, ceremonial, and medicinal. The pharmacological activity this plant has been studied using specimens recovered from religious use during Holy Week in Oaxaca, Mexico, sourced various localities within state. Geographical variability can influence the chemical composition plants, as environmental factors affect production their secondary metabolites, which impact biological properties. This research evaluated leaves pseudobulbs P. obtained different comprising 95-790 g 376-3900 fresh material pseudobulbs, respectively, per locality. Compounds were identified UHPLC-ESI-qTOF-MS/MS following ultrasound-assisted hydroethanolic extraction. Twenty-one compounds twenty pseudobulb. findings revealed differences across between species. Roaguia locality exhibited highest extraction yield potential leaves. For Cieneguilla showed yield, El Lazo had lowest but potential. study represents first comprehensive analysis variation a native Mexican orchid. In all localities, contained known activity, validating species medicine highlighting medical applications.

Language: Английский

Citations

0
Bioactives derived from egg by-products: Preparation, health benefits, and high-value-added applications DOI
Yue Huang,

Rui Chuang,

Mengzhuo Liu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143889 - 143889

Published: March 1, 2025

Language: Английский

Citations

0
The emerging role of honeysuckle flower in inflammatory bowel disease DOI Creative Commons

P. De Muro,

Caihong Jing,

Zhihan Zhao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues rise developing countries. Nonetheless, the existing therapies for have limitations fail address needs patients thoroughly. There is an increasing need new, safe, highly effective alternative medications patients. Traditional Chinese Medicine (TCM) employed drug development management due its wide-range biological activities, minimal toxicity, limited side effects. Extensive research has shown certain TCM exhibits significant therapeutic benefits treatments. Honeysuckle (Lonicera japonica) was used clinical settings IBD. Bioactive metabolites L. japonica, such luteolin, quercetin, cyanidin, chlorogenic acid (CGA), caffeic (CA), saponin, exhibit managing honeysuckle flower a potential candidate anti-inflammatory, immune system-regulating, antioxidant qualities. This paper reviews It discusses fundamental mechanism japonica bioactive prevention

Language: Английский

Citations

0
Comparative metabolomic profiling and biomarker identification reveal nutritional and antioxidant differences between Prunus tomentosa and Prunus avium DOI Creative Commons
Xingfan Li, Minghui Yang,

Xinyi Du

et al.

Food Chemistry X, Journal Year: 2025, Volume and Issue: 27, P. 102485 - 102485

Published: April 1, 2025

This study compares the nutritional and antioxidant attributes of Prunus avium tomentosa while investigating their metabolite relationships. The results indicate that P. has higher levels vitamin C, total anthocyanins, soluble protein, Ca, K, Zn, capacity. Additionally, its pits demonstrate superior antimicrobial activities compared to those avium. Metabolomic profiling using UPLC-QTOF-MS/MS identified 1019 metabolites, predominantly within flavonoids, organic acids, phenolic saccharides. Weighted gene co-expression network analysis linked these metabolites traits, emphasizing key pathways such as phenylpropanoid flavonoid biosynthesis. Multiple factor affirmed robustness findings, random forest pinpointed kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside, leucodelphidin, quercetagetin contributors attributes. In conclusion, this identifies biomarkers associated with properties, providing a scientific foundation for enhancing cultivation fruit quality improvement.

Language: Английский

Citations

0
Anti‐Inflammatory Effects of Lactiplantibacillus plantarum NCHU–FC1 Strain Co‐Fermented Cucumbers in Association with Increased Polyphenols and Exopolysaccharides DOI
Hsuan‐Min Wang, Shwu‐Jene Tsai, Jin‐Yuarn Lin

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)

Published: April 1, 2025

ABSTRACT Long‐term and excess chronic inflammation is related to most degenerative disorders in the body; however, particular lactic acid bacteria (LAB) fermented foods with anti‐inflammatory potential may reduce risk of these diseases. To develop LAB co‐fermented cucumbers, a Lactiplantibacillus ( Lpb .) plantarum NCHU–FC1 strain was isolated for preparing 5‐day Lpb. cucumbers spontaneously were selected compare their immunomodulatory functions. Water extracts, ethanol exopolysaccharides (EPS) from samples treat RAW 264.7 macrophages without or lipopolysaccharide (LPS) evaluate potential. Proinflammatory cytokines (interleukin [IL]‐1β, IL‐6, tumor necrosis factor [TNF]‐α) cytokine (IL‐10) produced by treated determined. The relationships between functional ingredients extracts effects analyzed. results showed that water both decreased pro‐/anti‐inflammatory secretion ratios LPS‐stimulated macrophages, exhibiting However, EPS (LEPS) demonstrated better effect than those cucumbers. Total polyphenol, flavonoid, saponin contents significantly negatively correlated IL‐6 levels IL‐6/IL‐10 corresponding cells, respectively. Our suggest ingredients, including polyphenolic components LEPS, inhibit macrophages. novel LAB‐fermented using have broader implications developing foods.

Language: Английский

Citations

0
Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials DOI Creative Commons
Jingjing Zhang, Linqing Wang,

Yingqi Mi

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 450 - 450

Published: Sept. 30, 2024

The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and (AA) was proposed, skillfully utilizing electrostatic attraction bond achieve controlled drugs. Based on this point, six crosslinked

Language: Английский

Citations

2
Noncentrifugal Sugar Extracts from Ethyl Acetate Inhibited Inflammatory Factor Expression through Relieving Cell Oxidation in Caco-2 Cells DOI

Liyixia Zhang,

Ronghua Chen,

Yuhuan Luo

et al.

ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Noncentrifugal sugar (NCS) is a type of unrefined made by evaporating the juice cane without separating molasses, thus it contains variety bioactive components. This study compared chemical properties and antioxidant activities NCS extracts with different solvents, anti-inflammatory were evaluated. The ethyl acetate extract showed higher efficiency in active ingredients highest content total phenols (28.80 mg/g) flavonoids (92.21 mg/g). Caffeic acid, chlorogenic acid protocatechuic main components nine phenolic substances extract. Results that 100 μg/mL significantly reduced ROS levels 78% t-BHP-induced Caco-2 cell models. SOD GSH-Px increased, MDA was noticeably decreased, which could almost eliminate effect t-BHP induced oxidative. secretion interleukin IL-6 decreased 72%, NO iNOS expression declining.

Language: Английский

Citations

0
Changes in the Profile of Phenolic Compounds and in the Antioxidant, Hypoglycemic, and Antidiabetic Activities of a Beverage Based on Sesame By-Product Caused by the Simulated Gastrointestinal Digestion Process DOI Creative Commons

Jonhatan Carrasco-Chávez,

María Fernanda Quintero-Soto, Rosalio Velarde-Barraza

et al.

Beverages, Journal Year: 2024, Volume and Issue: 10(4), P. 115 - 115

Published: Nov. 26, 2024

The by-product of extracting oil from sesame has good functional properties for use in the development new food products. In this study, effect simulated gastrointestinal digestion on bioaccessibility phenolic compounds, as well antioxidant, antidiabetic, and hypoglycemic a beverage by-products was analyzed. Oral significantly decreased total content beverage, while flavonoid increased. Both phytochemicals increased after gastric intestinal digestion. Twenty-five compounds were characterized including feruloylquinic acid, which present all digestive fractions most abundant free quercetin, also digested fractions. On other hand, isorhamnetin. During digestion, antioxidant activity inhibitory effects α-glucosidase DPP-IV improved, ability to inhibit α-amylase during oral remaining constant throughout Correlation analysis indicated that flavonoids, may be with greatest evaluated activities. results study not only improve understanding impact but suggest potential applications formulating foods enhanced hypoglycemic, antidiabetic properties, contributing health-promoting

Language: Английский

Citations

0