Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation DOI Open Access
Sherif Babatunde Adeyemi,

Ahmed Abiodun Saliu,

Bhrugesh Joshi

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 11(1), P. 719 - 742

Published: Dec. 2, 2024

The prevalence of diabetes mellitus is increasing, and well-known conventional medications are associated with harmful effects. Therefore, this study aimed to identify the compounds present in young leaves Daniellia oliveri assess their antidiabetic potential using an in-silico model. best column chromatographic fraction obtained from ethyl acetate was analyzed HRLC-MS prominent compounds. identified were subjected ADMET prediction online servers confirm draggability. In addition, screened for activity against type 2 molecular docking. Eight peaks identified, viz; gallic acid, 2,6-dihydroxybenzoic salicylic caffeic phenylacetaldehyde, 2,5-dimethylphenol, 3-(−4-Hydroxyphenyl) propionic 16-hydroxyhexadecanoic acid. Most phenolics had little toxic docking results revealed potentials inhibiting therapeutic targets 11β-hydroxysteroid dehydrogenase 1, human salivary alpha-amylase, glycogen phosphorylase, protein tyrosine phosphatase 1B, glutamine fructose-6-phosphate amidotransferase, sirtuin 6, dipeptidyl peptidase IV, responsible development diabetes. This has successfully revalidated provided scientific insight into usage D. managing by Nigerians. However, limitation remains purification lead that can serve as treatment medicinal practices.

Language: Английский

Effect of kombucha green tea (Camellia sinensis) on mRNA SREBP-1c expression of dyslipidemic model rats DOI

Linda,

Lina Lukitasari, Citrawati Dyah Kencono Wungu

et al.

Salud Ciencia y Tecnología - Serie de Conferencias, Journal Year: 2025, Volume and Issue: 4, P. 1520 - 1520

Published: Feb. 15, 2025

Introduction: Dyslipidemia is a condition marked by irregularities in the levels of lipids blood. The long-term use synthetic hypolipidemic drugs can lead to numerous side effects, necessitating search for alternative herbal remedies. Potential benefits kombucha green tea (KGT), traditional fermented drink with symbiotic SCOBY culture, known its hypocholesterolemic, hepatoprotective, and antioxidant effects. These properties contribute management advanced dyslipidemia enhancing activation AMPK, which represses transcription SREBP-1c involved coding genes related de novo lipogenesis liver. This study aims investigate potential KGT Rattus norvegicus dyslipidemia.Methods: experiment was conducted on five groups male norvegicus, including control group (DLP), healthy (NC), DLP intervention at doses 70, 85, 100 mg/kg BW. mRNA expression analyzed using Real Time-qPCR.Results: Significant decrease TC, LDL, TG an increase HDL between (p<0.05). Moreover, also decreased all treatment compared (p<0.05).Conclusions: Supplementation this shown reduce level liver improve serum lipid profile dyslipidemic rats.

Language: Английский

Citations

0
Exploring Betula alnoides Bark: Insilico and Preclinical Insights into its Antioxidant and Lipid-Lowering Effects in Hypercholesterolemia DOI
Shahbaz Khan, Alka Lohani, Prashant Tiwari

et al.

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100583 - 100583

Published: Jan. 1, 2025

Language: Английский

Citations

0
Phytochemical analysis and hypolipidaemic activity of Cestrum nocturnum (Solanaceae: Solanales) extract in normal albino rat DOI
Goutam Chandra, Indranil Bhattacharjee,

S. K. Chatterjee

et al.

DELETED, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Sources, metabolism, health benefits and future development of saponins from plants DOI
Jiang Wang, Xin Tang, Fei Liu

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115226 - 115226

Published: Oct. 22, 2024

Language: Английский

Citations

2
Daniellia oliveri as a type 2 diabetes remedy: evidence from in-silico evaluation DOI Open Access
Sherif Babatunde Adeyemi,

Ahmed Abiodun Saliu,

Bhrugesh Joshi

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 11(1), P. 719 - 742

Published: Dec. 2, 2024

The prevalence of diabetes mellitus is increasing, and well-known conventional medications are associated with harmful effects. Therefore, this study aimed to identify the compounds present in young leaves Daniellia oliveri assess their antidiabetic potential using an in-silico model. best column chromatographic fraction obtained from ethyl acetate was analyzed HRLC-MS prominent compounds. identified were subjected ADMET prediction online servers confirm draggability. In addition, screened for activity against type 2 molecular docking. Eight peaks identified, viz; gallic acid, 2,6-dihydroxybenzoic salicylic caffeic phenylacetaldehyde, 2,5-dimethylphenol, 3-(−4-Hydroxyphenyl) propionic 16-hydroxyhexadecanoic acid. Most phenolics had little toxic docking results revealed potentials inhibiting therapeutic targets 11β-hydroxysteroid dehydrogenase 1, human salivary alpha-amylase, glycogen phosphorylase, protein tyrosine phosphatase 1B, glutamine fructose-6-phosphate amidotransferase, sirtuin 6, dipeptidyl peptidase IV, responsible development diabetes. This has successfully revalidated provided scientific insight into usage D. managing by Nigerians. However, limitation remains purification lead that can serve as treatment medicinal practices.

Language: Английский

Citations

0