Antioxidant Effects and Potential Mechanisms of Citrus reticulata ‘Chachi’ Components: An Integrated Approach of Network Pharmacology and Metabolomics DOI Creative Commons
Jingfa Xiao,

Tian Sun,

Shengyu Jiang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4018 - 4018

Published: Dec. 12, 2024

Citrus reticulata ‘Chachi’ (CRC), recognized for its considerable edible and medicinal significance, is a valuable source of metabolites beneficial to human health. This research investigates the metabolic distinctions antioxidant properties across four different parts CRC, using multivariate statistical analysis interpret metabolomic data network pharmacology identify potential targets relevant signaling pathways. The results indicate differences in sample, with 1622 showing differential expression, including 816 secondary metabolites, primarily consisting terpenoids (31.02%) flavonoids (25.22%). dried mature citrus peel (CP) section demonstrates highest level total phenolics (6.8 mg/g), followed by pulp without seed (PU) (4.52 (PWS) (4.26 (SE) (2.16 mg/g). Interestingly, targeted high-performance liquid chromatography reveals nobiletin tangeretin CP, whereas PU has hesperidin, narirutin, didymin. Furthermore, all sections CRC exhibit robust vitro assessments (CP > PWS SE). Lastly, uncovered mechanisms CRC. offers deeper insights into development utilization byproducts processing industry.

Language: Английский

Antioxidant Effects and Potential Mechanisms of Citrus reticulata ‘Chachi’ Components: An Integrated Approach of Network Pharmacology and Metabolomics DOI Creative Commons
Jingfa Xiao,

Tian Sun,

Shengyu Jiang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4018 - 4018

Published: Dec. 12, 2024

Citrus reticulata ‘Chachi’ (CRC), recognized for its considerable edible and medicinal significance, is a valuable source of metabolites beneficial to human health. This research investigates the metabolic distinctions antioxidant properties across four different parts CRC, using multivariate statistical analysis interpret metabolomic data network pharmacology identify potential targets relevant signaling pathways. The results indicate differences in sample, with 1622 showing differential expression, including 816 secondary metabolites, primarily consisting terpenoids (31.02%) flavonoids (25.22%). dried mature citrus peel (CP) section demonstrates highest level total phenolics (6.8 mg/g), followed by pulp without seed (PU) (4.52 (PWS) (4.26 (SE) (2.16 mg/g). Interestingly, targeted high-performance liquid chromatography reveals nobiletin tangeretin CP, whereas PU has hesperidin, narirutin, didymin. Furthermore, all sections CRC exhibit robust vitro assessments (CP > PWS SE). Lastly, uncovered mechanisms CRC. offers deeper insights into development utilization byproducts processing industry.

Language: Английский

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