Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review DOI Creative Commons

Lia Mardiana,

Tiana Milanda, Yuni Elsa Hadisaputri

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 201 - 218

Published: Jan. 1, 2025

Purpose: Phytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These such as flavonoids, terpenoids, alkaloids, possess significant anticancer potential but are often limited by poor solubility low absorption. This review aims to investigate how phytosome encapsulation improves pharmacokinetic profiles effectiveness these bioactive compounds. Patients Methods: comprehensive is based on analysis recent literature retrieved from PubMed, Scopus, ScienceDirect databases. It focuses findings preclinical vitro studies that examine enhancements provided technology when applied metabolites. Results: Phytosome-encapsulated metabolites exhibit significantly improved solubility, absorption, distribution, cellular uptake compared non-encapsulated forms. enhanced facilitates more effective inhibition pathways, including NF-κB PI3K/AKT, leading increased models. Conclusion: has demonstrated its overcome challenges, resulting safer options highlights phytosome-based formulations novel approach therapy, supporting further development preclinical, vitro, clinical applications. Keywords: phytosome, cancer,

Language: Английский

Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases DOI Open Access
Adele Muscolo, Mariateresa Oliva, Torello Giulio

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3264 - 3264

Published: March 13, 2024

Oxidative stress, characterized by an imbalance favouring oxidants over antioxidants, is a key contributor to the development of various common diseases. Counteracting these considered effective strategy mitigate levels oxidative stress in organisms. Numerous studies have indicated inverse correlation between consumption vegetables and fruits risk chronic diseases, attributing health benefits presence antioxidant phytochemicals foods. Phytochemicals, present wide range foods medicinal plants, play pivotal role preventing treating diseases induced working as antioxidants. These compounds exhibit potent antioxidant, anti-inflammatory, anti-aging, anticancer, protective properties against cardiovascular diabetes mellitus, obesity, neurodegenerative conditions. This comprehensive review delves into significance averting managing elucidating sources invaluable elements. Additionally, it provides summary recent advancements understanding associated with phytochemicals.

Language: Английский

Citations

102
Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence DOI Creative Commons
Zohra Nausheen Nizami, Hanan E. Aburawi, Abdelhabib Semlali

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1159 - 1159

Published: May 26, 2023

Reactive oxygen species (ROS) are metabolic byproducts that regulate various cellular processes. However, at high levels, ROS induce oxidative stress, which in turn can trigger cell death. Cancer cells alter the redox homeostasis to facilitate protumorigenic processes; however, this leaves them vulnerable further increases levels. This paradox has been exploited as a cancer therapeutic strategy with use of pro-oxidative drugs. Many chemotherapeutic drugs presently clinical use, such cisplatin and doxorubicin, one their mechanisms action. Further, drugs, including phytochemicals small molecules, being investigated preclinical studies attribute anticancer activity induction. Consistently, review aims highlight selected whose potential characterized specific focus on phytochemicals, induction, effects downstream

Language: Английский

Citations

31
Impact of nanotechnology on the oral delivery of phyto-bioactive compounds DOI Open Access
Hamdi Nsairat, Zainab Lafi, Mazen Al-Sulaibi

et al.

Food Chemistry, Journal Year: 2023, Volume and Issue: 424, P. 136438 - 136438

Published: May 22, 2023

Language: Английский

Citations

30
Flavonoids and gastrointestinal health: single molecule for multiple roles DOI

Haijing Lan,

Hui Wang, Chong Chen

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(30), P. 10987 - 11005

Published: July 6, 2023

Diet can be considered as one of the pivotal factors in regulating gastrointestinal health, and polyphenols widely distributed human daily diet. The their metabolites playing a series beneficial effects tract that regulate gut microbiota, increase intestinal barrier function, repair mucosa, reduce oxidative stress, inhibit secretion inflammatory immune absorption biotransformation mainly depend on activity microflora. However, little is known about two-way interaction between microbiota. objective this review to highlight structure optimization effect flavonoids flora, discusses mechanisms dietary flora. multiple single molecule flavonoids, inter-dependence microbiota polyphenol metabolites. Moreover, protective plant macromolecules health. This provided valuable insight may useful for better understanding mechanism health polyphenols, provide scientific basis application functional food.

Language: Английский

Citations

26
Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy DOI
Sunny Shah,

Harshida Chauhan,

Hardik Madhu

et al.

Pharmaceutical Nanotechnology, Journal Year: 2024, Volume and Issue: 13(1), P. 70 - 89

Published: Jan. 26, 2024

Phytopharmaceuticals, derived from natural sources, manifest tremendous potential for therapeutic applications. Nevertheless, effective delivery of these bio-actives presents significant challenges. A breakthrough in fortifying phytopharmaceuticals within phosphatidylcholine is a promising remedy to overcome solubility, permeability, and other related drawbacks. This intrinsic lipid, which obtained both synthetic confers numerous benefits, encompassing heightened augmented bioavailability, enhanced stability. The conjugation with enables improved dermal permeation, absorption, targeted distribution, the possibility synergistic results, eventually improving efficacy. Additionally, use enriched route overcoming limitations imposed by conventional techniques, encouraging more treatments. review provides thorough analysis phosphatidylcholine- incorporated as nanomedicine variables that significantly affect their Moreover, elaborates on how improves tissue distribution boosts phytopharmaceuticals. Further, underscores significance nano-formulation strategies, analytical methodologies, forthcoming prospects propel this field forward. Furthermore, emphasizes inherent innovative approach while highlighting importance additional research endeavors collaborative initiatives unlock benefits phosphatidylcholinefortified phytopharmaceuticals, enhancing patient well-being.

Language: Английский

Citations

10
Metal Oxide–Enhanced Para-Coumaric Acid Nanoparticles for Precision Targeting of Leishmania donovani DOI
Kartikesh Sahu,

Raj Amrit Singh Samant,

Tiasha Routh

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Plant protein-based Pickering emulsion for the encapsulation and delivery of fat-soluble vitamins: A systematic review DOI

Srishti Upadhyay,

Vijay Singh Sharanagat

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141635 - 141635

Published: March 1, 2025

Language: Английский

Citations

1
Recent advancements in genistein nanocarrier systems for effective cancer management DOI

Diya Arora,

Vanshita Singh,

Hemant Bhati

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 12, 2025

Language: Английский

Citations

1
Co-encapsulation of curcumin and quercetin with zein/HP-β-CD conjugates to enhance environmental resistance and antioxidant activity DOI Creative Commons
Chao Qiu, Zhiheng Zhang,

Xiaojing Li

et al.

npj Science of Food, Journal Year: 2023, Volume and Issue: 7(1)

Published: June 14, 2023

In this study, composite nanoparticles consisting of zein and hydroxypropyl beta-cyclodextrin were prepared using a combined antisolvent co-precipitation/electrostatic interaction method. The effects calcium ion concentration on the stability containing both curcumin quercetin investigated. Moreover, bioactivity characterized before after encapsulation. Fluorescence spectroscopy, Fourier Transform infrared X-ray diffraction analyses indicated that electrostatic interactions, hydrogen bonding, hydrophobic interactions main driving forces for formation nanoparticles. addition ions promoted crosslinking proteins affected protein-cyclodextrin particles through screening binding effects. to improved encapsulation efficiency, antioxidant activity, quercetin. However, there was an optimum (2.0 mM) provided best protective nutraceuticals. crosslinked shown maintain good under different pH simulated gastrointestinal digestion conditions. These results suggest zein-cyclodextrin may be useful plant-based colloidal delivery systems bio-active agents.

Language: Английский

Citations

21
A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity DOI Creative Commons
Shahida Anusha Siddiqui, Iskandar Azmy Harahap,

Priyanka Suthar

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(19), P. 3610 - 3610

Published: Sept. 28, 2023

Obesity is a complex medical condition mainly caused by eating habits, genetics, lifestyle, and medicine. The present study deals with traditional diets like the Mediterranean diet, Nordic African Heritage Asian DASH, as these are considered to be sustainable for curing obesity. However, bioavailability of phytonutrients consumed in diet may vary, depending on several factors such digestion absorption phytonutrients, interaction other substances, cooking processes, individual differences. Hence, phytochemicals, polyphenols, alkaloids, saponins, terpenoids, etc., have been investigated assess their efficiencies safety prevention treatment These phytochemicals anti-obesity effects, mediated via modulation many pathways, decreased lipogenesis, lipid absorption, accelerated lipolysis, energy intake, expenditure, preadipocyte differentiation proliferation. Owing new food formulations incorporating were introduced that can beneficial reducing prevalence obesity promoting public health.

Language: Английский

Citations

18