Covalent Modification of Selenium in Polysaccharide Enhances Immunoregulation Activity via the TLR4-Mediated MAPK/NF-κB Signaling Pathway DOI

Aijuan Bao,

Zhangkun Wei,

Mangmang Bai

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Selenium (Se) is a crucial trace element that demonstrates significant immunomodulatory effects, which are attributed to the variability in its valence states and metabolic pathways. To investigate Se-related immunoregulatory locust bean gum (LBG), typical galactomannan, was selenized by employing deep eutectic solvents (DESs) as high-efficiency obtain Se-covalent modified LBG (SeLBGs) with similar molecular mass different Se contents (SeLBGL, 1049.57 SeLBGH, 4926.54 μg/g). After introducing selenite into LBG, SeLBGs display greater activities activating MAPKs NF-κB signaling pathways compared compounds (Se-Met, Na2SeO3, SeNPs) at same equivalent, confirmed their higher cell viability, phagocytic activity, secretion of cytokines, protein expression. In addition, docking dynamics suggest SeLBG has potential induce dimerization subunits activate toll-like receptors (TLRs). By specific receptor inhibitors strategy, it combination enhances TLR2/4 recognition according results cytokine MAPKs/NF-κB pathway-related These findings underscore role pattern Se-enriched ingredients various functions.

Language: Английский

Interface behavior, competitive substitution, and saltiness perception of switchable water-in-oil high internal phase emulsions-based delivery carrier for sodium salt regulated by OSA starch DOI

Xinshuo Wang,

Shuqin Xia, Khizar Hayat

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111162 - 111162

Published: Feb. 1, 2025

Language: Английский

Citations

1
Enhancing function, stability, and intracellular uptake of kaempferol in zein-pectin nanoemulsions by a novel dual-frequency pulsed ultrasound system DOI
Wenjuan Qu, Xinyue Deng, Yuhan Li

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111466 - 111466

Published: April 1, 2025

Language: Английский

Citations

0
Potassium-induced κ-carrageenan helices resist degradation by gut microbiota in an in vitro model DOI
Dan Yuan,

Ao Gao,

Tianyi Li

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 158, P. 110591 - 110591

Published: Aug. 31, 2024

Language: Английский

Citations

0
Improved Emulsifying Performance of Agarose Microgels by Cross-Interfacial Diffusion of Polyphenols DOI
Wenxin Jiang,

Xinwei Xiong,

Hefan Zhang

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(46), P. 24662 - 24674

Published: Nov. 6, 2024

Noninterface-active polysaccharides can acquire better emulsifying properties through microgelation, yet optimizing their performance remains a significant challenge. This study introduces novel approach to enhance the of polysaccharide microgels by leveraging cross-interfacial diffusion polyphenols, which promotes interfacial adsorption microgels. Tannic acid (TA) was predispersed in oil phases and subsequently emulsified with agarose microgel (AM) suspensions, impacts TA on AMs investigated. In addition, transmittance profiles oil-water biphasic systems were found innovatively indicate AMs. The current results suggest that an appropriate level incorporation benefit AMs, correlating decreased droplet sizes improved physical stability emulsion. However, excessive might trigger clustering before they reach layer, adversely affecting emulsion stability. conclusion, polyphenols offers promising strategy overcome challenges encountered microgel-stabilized emulsions.

Language: Английский

Citations

0
Covalent Modification of Selenium in Polysaccharide Enhances Immunoregulation Activity via the TLR4-Mediated MAPK/NF-κB Signaling Pathway DOI

Aijuan Bao,

Zhangkun Wei,

Mangmang Bai

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Selenium (Se) is a crucial trace element that demonstrates significant immunomodulatory effects, which are attributed to the variability in its valence states and metabolic pathways. To investigate Se-related immunoregulatory locust bean gum (LBG), typical galactomannan, was selenized by employing deep eutectic solvents (DESs) as high-efficiency obtain Se-covalent modified LBG (SeLBGs) with similar molecular mass different Se contents (SeLBGL, 1049.57 SeLBGH, 4926.54 μg/g). After introducing selenite into LBG, SeLBGs display greater activities activating MAPKs NF-κB signaling pathways compared compounds (Se-Met, Na2SeO3, SeNPs) at same equivalent, confirmed their higher cell viability, phagocytic activity, secretion of cytokines, protein expression. In addition, docking dynamics suggest SeLBG has potential induce dimerization subunits activate toll-like receptors (TLRs). By specific receptor inhibitors strategy, it combination enhances TLR2/4 recognition according results cytokine MAPKs/NF-κB pathway-related These findings underscore role pattern Se-enriched ingredients various functions.

Language: Английский

Citations

0