Co-encapsulation of Lactobacillus acidophilus and different concentrations of chia oil (Salvia hispanica L.) by external ionic gelation

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111171 - 111171

Published: Feb. 1, 2025

Language: Английский

Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101711 - 101711

Published: March 27, 2025

Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that mucosal adhesion properties of hydrogels play a potential role in treatment periodontitis. The hydrogel improve contact retention time drugs periodontal pocket. Through mucosa, it interacts mucin coating surface epithelium teeth to form specific interface force. exhibits strong (adhesion strength: 5-6 N/cm2) prolonged pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH reactive oxygen species (ROS). This design overcomes limitations poor mechanical stability conventional formulations. balance oral microbiota plays an important maintaining health. Probiotics, colonizing cavity, transform infected site from environment rich inflammatory cytokines more benign environment, inhibit harmful pathogenic microorganisms, contribute overall Microenvironment sensitive perform sol gel transformation situ, accurately control when exposed various stimuli (such as temperature change, light, species, etc.). Oral probiotics anti-inflammatory are encapsulated proliferation pathogens planting mouth producing metabolites, effectively preventing treating diseases.

Language: Английский

Synthesis, characterization of thiolated hyaluronic acid and evaluation of its encapsulation effects on Limosilactobacillus reuteri HR7

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143486 - 143486

Published: April 23, 2025

Language: Английский