Dietary emulsifier Polysorbate 80-induced lipotoxicity promotes intestinal senescence

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116165 - 116165

Published: March 1, 2025

Language: Английский

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Caloric restriction mimetics: effects of spermidine and berberine on healthy longevity and prevention of aging-associated diseases.

Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 17, 2025

Introduction: Aging is a complex biological process associated with the accumulation of cellular damage, loss proteostasis, and mitochondrial dysfunction, which contribute to development chronic diseases. Spermidine berberine are natural compounds complementary properties that promote healthy longevity by targeting key path ways such as autophagy biogenesis. The objective this review evaluate mechanisms action, benefits, limitations spermidine explore their synergistic potential anti-aging agents in personalized medicine strategies. Methods: A narrative scientific literature was conducted analyze effects preclinical clinical models. Relevant studies focusing on molecular mechanisms, therapeutic applications, practical were examined. Results: stimulates inhibiting acetyltransferases, improving protein quality, reducing toxic aggregates aging. Berberine activates AMPK SIRT1, enhancing biogenesis regulating energy metabolism. Both have shown efficacy animal models cognitive function, oxidative stress, preventing metabolic However, low bioavailability lack longitudinal limit application. Discussion: address proteostasis bioenergetics simultaneously. Their combination represents promising multifactorial approach but requires advances formulations optimize absorption stability. Clinical trials essential validate safety humans. Conclusions: significant medicine. integration into therapies could improve quality life prevent diseases, although additional needed overcome current limitations.

Language: Английский

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Effect of Agaricus bisporus Polysaccharides on Human Gut Microbiota during In Vitro Fermentation: An Integrative Analysis of Microbiome and Metabolome

Foods, Journal Year: 2023, Volume and Issue: 12(4), P. 859 - 859

Published: Feb. 17, 2023

polysaccharide (ABP) is an important active component in edible mushrooms, but its interaction with gut microbiota unclear. Therefore, this study evaluated the effect of ABP on composition and metabolites human by

Language: Английский

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Nutrient-epigenome interactions: Implications for personalized nutrition against aging-associated diseases

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 127, P. 109592 - 109592

Published: Feb. 5, 2024

Language: Английский

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Exploration of green preparation strategy for Lycium barbarum polysaccharide targeting Bacteroides proliferative and immune-enhancing activities and its potential use in geriatric foods

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131316 - 131316

Published: April 2, 2024

Language: Английский

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Intestinal organoids: A thriving and powerful tool for investigating dietary nutrients-intestinal homeostasis axis

Food Research International, Journal Year: 2023, Volume and Issue: 172, P. 113109 - 113109

Published: June 12, 2023

Language: Английский

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Interactions between wheat germ polysaccharide and gut microbiota through in vitro batch fecal fermentation and an aging mice model: Targeting enrichment of Bacteroides uniformis and Bifidobacterium pseudocatenulatum

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127559 - 127559

Published: Oct. 19, 2023

Language: Английский

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Dose-dependent effect of Dendrobium officinale polysaccharide on anti-aging in Caenorhabditis elegans: A metabolomics analysis focused on lipid and nucleotide metabolism regulation

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104615 - 104615

Published: June 21, 2024

Language: Английский

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Ergothioneine improves cognitive function through ameliorating mitochondrial damage and decreasing neuroinflammation in a d-galactose-induced aging model

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

EGT intervention significantly improved d -galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.

Language: Английский

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Gut microbial evidence chain in high-salt diet exacerbates intestinal aging process

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 28, 2022

Although excessive salt consumption appears to hasten intestinal aging and increases susceptibility cardiovascular disease, the molecular mechanism is unknown. In this study, mutual validation of high (HS) fecal microbiota transplantation (FMT) in C56BL/6 mice was used clarify by which causes aging. Firstly, we observed HS vascular endothelial damage can accelerate associated with decreased colon serum expression superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), increased malondialdehyde (MDA); after mice, also occur. Secondly, found older aged 14 months; microbiota, same effect 6–8 weeks. Meanwhile, significantly changed gut microbial diversity composition, transferable FMT. Eventually, based on core genera both network, a machine learning model constructed could predict Further investigation revealed that process HS-related highly linked signal transduction mediated various bacteria. conclusion, present study provides an experimental basis potential evidence related Even, avoiding actively intervening alteration may assist delay state drives clinical practice.

Language: Английский

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