International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6348 - 6348
Published: June 8, 2024
Cancers
are
causing
millions
of
deaths
and
leaving
a
huge
clinical
economic
burden.
High
costs
cancer
drugs
limiting
their
access
to
the
growing
number
cases.
The
development
more
affordable
alternative
therapy
could
reach
patients.
As
gut
microbiota
plays
significant
role
in
treatment
cancer,
microbiome-targeted
has
gained
attention
recent
years.
Dietary
natural
compounds
can
modulate
composition
while
providing
broader
accessible
medicine.
Tea
have
been
shown
anti-cancer
properties
as
well
related
metabolites.
However,
there
is
no
comprehensive
review
that
focuses
on
modulatory
effects
tea
impact
reshaping
metabolic
profiles,
particularly
models.
In
this
review,
different
settings
discussed.
Furthermore,
relationship
between
these
modulated
bacteria
metabolites,
along
with
mechanisms
how
changes
led
intervention
summarized.
Animals,
Journal Year:
2024,
Volume and Issue:
14(18), P. 2661 - 2661
Published: Sept. 12, 2024
This
study
investigated
the
impact
of
tea
polyphenols
on
serum
indices,
rumen
microorganisms,
metabolism,
and
liver
metabolism
in
Hu
sheep.
Sixty
healthy
lambs,
aged
three
months
with
similar
average
weights,
were
chosen
randomly
assigned
to
control
(CON),
TP400,
TP800,
TP1200
groups,
each
consisting
fifteen
lambs.
The
group
received
a
basal
diet,
while
experimental
groups
provided
diet
supplemented
400
mg/kg,
800
1200
mg/kg
polyphenols,
respectively.
Compared
CON
group,
addition
significantly
increased
IgA,
GSH-Px,
TSOD.
In
addition,
able
increase
pH
but
had
no
significant
effect
NH
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
116, P. 106185 - 106185
Published: April 18, 2024
Theabrownin
(TB)
is
the
main
characteristic
component
and
bioactive
substance
of
Pu-erh
tea.
Our
previous
studies
have
demonstrated
interactions
among
TB,
circadian
rhythm,
obesity,
but
underlying
mechanism
remains
unclear.
In
this
study,
we
focused
on
by
which
TB
ameliorates
lipid
accumulation
caused
oleic
acid
(OA)
modulating
rhythm
genes
in
HepG2
cells.
The
results
showed
that
could
reduce
triglyceride
(TG),
total
cholesterol
(TC),
low-density
lipoprotein
(LDL-C)
levels,
reactive
oxygen
species
(ROS)
overproduction
droplet
formation.
Additionally,
regulate
OA-mediated
desynchrony
regulating
mRNA
protein
expression
genes.
Furthermore,
as
revealed
proteomics
results,
PPAR
pathway
a
potential
through
metabolism
disorders.
After
Bmal1
knockdown,
ameliorative
effect
OA-induced
PPARγ
plin1
was
decreased,
suggested
ameliorate
cells
via
Bmal1-dependent
pathway.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6348 - 6348
Published: June 8, 2024
Cancers
are
causing
millions
of
deaths
and
leaving
a
huge
clinical
economic
burden.
High
costs
cancer
drugs
limiting
their
access
to
the
growing
number
cases.
The
development
more
affordable
alternative
therapy
could
reach
patients.
As
gut
microbiota
plays
significant
role
in
treatment
cancer,
microbiome-targeted
has
gained
attention
recent
years.
Dietary
natural
compounds
can
modulate
composition
while
providing
broader
accessible
medicine.
Tea
have
been
shown
anti-cancer
properties
as
well
related
metabolites.
However,
there
is
no
comprehensive
review
that
focuses
on
modulatory
effects
tea
impact
reshaping
metabolic
profiles,
particularly
models.
In
this
review,
different
settings
discussed.
Furthermore,
relationship
between
these
modulated
bacteria
metabolites,
along
with
mechanisms
how
changes
led
intervention
summarized.
