The structure of anthocyanins and the copigmentation by common micromolecular copigments: A review

Food Research International, Journal Year: 2023, Volume and Issue: 176, P. 113837 - 113837

Published: Dec. 13, 2023

Language: Английский

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Effects of Negative Ion Treatment on Postharvest Storage Quality and Anthocyanin Metabolism of Grape

Published: Jan. 1, 2025

Language: Английский

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Brazilian berries: The superfruits we need for the future

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 173 - 205

Published: Jan. 1, 2025

Language: Английский

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Oral intake of Hibiscus sabdariffa L. increased c-Myc and caspase-3 gene expression and altered microbial population in colon of BALB/c mice induced to preneoplastic lesions

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: March 5, 2025

Language: Английский

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Effects of negative air ion treatment on postharvest storage quality and anthocyanin metabolism of grape

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143700 - 143700

Published: March 1, 2025

Language: Английский

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Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1171 - 1171

Published: April 12, 2024

Colorectal carcinoma (CRC) is a major global health concern, with cancer metastasis being the main cause of patient mortality, and current CRC treatments are challenged by drug resistance. Although natural compounds, especially in foods like hawthorn proanthocyanidin extract (HPOE), have good anticancer activity, their effects on remain unknown. Therefore, our objective was to investigate impact potential mechanisms HPOE movement infiltration cells HCT116 cells. Firstly, scratch-healing experiments confirmed anti-migratory anti-invasive capabilities HPOE. Then, network pharmacology identified 16 possible targets, including MMP-9. Subsequently, RT-qPCR Western blotting that downregulated epithelial-mesenchymal transition-related factors (N-cadherin MMP-9) inhibited Wnt/β-catenin pathway activation. Finally, these results were experimentally validated using Wnt activator Licl inhibitor XAV939. It had certain inhibitory effect activation signaling caused could enhance Our findings provide basis for developing functional or dietary supplements, positioning as food raw material adjuvant treatment CRC, given its ability inhibit through pathway.

Language: Английский

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Αnti-prion effects of anthocyanins

Redox Biology, Journal Year: 2024, Volume and Issue: 72, P. 103133 - 103133

Published: March 28, 2024

Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They characterized by the conformational conversion of normal cellular prion protein, PrPC, into pathogenic isoform, PrPSc. diseases invariably fatal despite ongoing research, no effective prophylactic or therapeutic avenues currently available. Anthocyanins (ACNs) unique flavonoid compounds interest in their use potential neuroprotective and/or agents against NDs, has increased significantly recent years. Therefore, we investigated anti-oxidant anti-prion effects Oenin Myrtillin, two most common anthocyanins, using accepted field overexpressing PrPSc vitro model a cell free protein aggregation model. Our results, indicate both anthocyanins strong compounds, upregulating expression genes involved response, reducing levels Reactive Oxygen Species (ROS), produced due to infection, through activation Keap1-Nrf2 pathway. Importantly, they showcased remarkable potential, not only caused clearance aggregates, but completely inhibited formation fibrils Cerebrospinal Fluid (CSF) patients with Creutzfeldt–Jakob disease (CJD). Myrtillin possess pleiotropic effects, suggesting promising preventive possibly spectrum proteinopathies.

Language: Английский

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Phenolic compounds in grapes (genus Vitis): A review of their antioxidant activity, antiproliferative capacity, and cytotoxic effect on colorectal cancer

Journal of Applied Pharmaceutical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In the pursuit of potent antioxidant sources for potential health benefits, significant attention has been directed toward polyphenols. This research is especially relevant in context colorectal cancer (CRC), a widespread and deadly malignancy. The exploration preventive strategies led to growing interest grapes their derivatives, such as juices wines, which offer various consumption options based on grape type. investigation encompasses comprehensive analysis multiple components: skin, pulp, seed, pomace, wine, juice, extracts. These assessments serve critical reference exploring functional ingredients from chemopreventive agents against colon cancer. scientific literature review aims provide an in-depth overview advancements 2012 2023. A systematic reveals varying polyphenol concentrations different components correlation with capacities. addition, chemical profiles these matrices are analyzed concerning properties, antiproliferative effects, cytotoxicity, validated through vitro vivo models simulating CRC scenarios. seeks demonstrate grapes’ potential, diverse forms, promising food options.

Language: Английский

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Microbiome-based precision nutrition: Prebiotics, probiotics and postbiotics

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 237 - 310

Published: Jan. 1, 2024

Language: Английский

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Causal associations between dietary factors and colorectal cancer risk: a Mendelian randomization study

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 1, 2024

Background Previous epidemiological studies have found a link between colorectal cancer (CRC) and human dietary habits. However, the inherent limitations inevitable confounding factors of observational may lead to inaccurate doubtful results. The causality CRC remains elusive. Methods We conducted two-sample Mendelian randomization (MR) analyses utilizing data sets from IEU Open GWAS project. exposure datasets included alcoholic drinks per week, processed meat intake, beef poultry oily fish non-oily lamb/mutton pork cheese bread tea coffee cooked vegetable cereal fresh fruit salad/raw dried intake. In our MR analyses, inverse variance weighted (IVW) method was employed as primary analytical approach. median, MR-Egger, mode, simple mode were also applied quality control. Heterogeneity pleiotropic implemented replenish accuracy Results consequences revealed that week [odds ratio (OR): 1.565, 95% confidence interval (CI): 1.068–2.293, p = 0.022], intake (OR: 0.286; CI: 0.095–0.860; 0.026), 0.513; 0.273–0.964; 0.038), 0.435; 0.253–0.476; 0.003) 0.522; 0.311–0.875; 0.014) causally correlated with risk CRC. No other significant relationships obtained. sensitivity proposed absence heterogeneity or pleiotropy, demonstrating reliability Conclusion This study indicated associated an increased CRC, while decreased in this research not current is first establish comprehensive diet-related at genetic level, offering novel clues for interpreting etiology replenishing new perspectives clinical practice gastrointestinal disease prevention.

Language: Английский

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