Processes, Journal Year: 2023, Volume and Issue: 11(11), P. 3210 - 3210
Published: Nov. 10, 2023
In this study, we have focused on studying the heterogenous degradation kinetics regarding decomposition of emergency contraceptive agent levonorgestrel (LNG), which is a second-generation synthetic progestogen that active component racemic mixture norgestrel. The processes pharmaceutical ingredient (API) were compared with ones obtained from model system containing API along excipients are found in commercialized formulation mass ratio 1:1 (LNGMIX), order to observe if stabilizing or destabilizing effect progestogen. To achieve this, following investigational methods used: FTIR (Fourier transform infrared) spectroscopy and thermal analysis (TG/DTG/DSC analysis). For kinetic analysis, data two main observed DTG curves used processed preliminary method, namely ASTM E698, isoconversional methods: Friedman Flynn–Wall–Ozawa. study revealed mechanisms both LNG LNGMIX complex, tablet.
Language: Английский