The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1314 - 1314

Published: Jan. 21, 2024

Mitochondria are critical for providing energy to maintain cell viability. Oxidative phosphorylation involves the transfer of electrons from substrates oxygen produce adenosine triphosphate. also regulate proliferation, metastasis, and deterioration. The flow in mitochondrial respiratory chain generates reactive species (ROS), which harmful cells at high levels. stress caused by ROS accumulation has been associated with an increased risk cancer, cardiovascular liver diseases. Glutathione (GSH) is abundant cellular antioxidant that primarily synthesized cytoplasm delivered mitochondria. Mitochondrial glutathione (mGSH) metabolizes hydrogen peroxide within A long-term imbalance ratio mGSH can cause dysfunction, apoptosis, necroptosis, ferroptosis, may lead disease. This study aimed review physiological functions, anabolism, variations organ tissue accumulation, delivery GSH mitochondria relationships between levels, GSH/GSH disulfide (GSSG) ratio, programmed death, ferroptosis. We discuss diseases deficiency related therapeutics.

Language: Английский

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Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 12, 2023

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.

Language: Английский

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Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 18

Published: May 16, 2022

Hepatocellular carcinoma is a malignant tumor that poses serious threat to human health. Ferroptosis, which represents an identified type of regulated iron-dependent cell death, may play important role in hepatocellular carcinoma. However, it unclear as whether ferroptosis involved with the mechanisms lncRNA HULC liver cancer cells. Here, we show knockdown increases and oxidative stress We also found changes some related miRNAs cells treated siRNA. Differential miRNA expression levels were determined use high-throughput sequencing prediction target genes using bioinformatics analysis. was function ceRNA miR-3200-5p, miR-3200-5p regulates by targeting ATF4, resulting inhibition proliferation metastasis within HCC In summary, these findings illuminate molecular through downregulation induces miR-3200-5p/ATF4 axis modulate development

Language: Английский

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Ferroptosis in gastrointestinal cancer: from mechanisms to implications

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216147 - 216147

Published: March 24, 2023

Language: Английский

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The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 820 - 820

Published: May 11, 2023

Cell death includes programmed and nonprogrammed cell death. The former mainly ferroptosis, necroptosis, pyroptosis, autophagy, apoptosis, while the latter refers to necrosis. Accumulating evidence shows that pyroptosis play essential regulatory roles in development of intestinal diseases. In recent years, incidence inflammatory bowel disease (IBD), colorectal cancer (CRC), injury induced by ischemia-reperfusion (I/R), sepsis, radiation have gradually increased, posing a significant threat human health. advancement targeted therapies for diseases based on provides new strategies treating Herein, we review with respect regulation highlight underlying molecular mechanisms potential therapeutic applications.

Language: Английский

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Ferroptosis: Biology and Role in Gastrointestinal Disease

Gastroenterology, Journal Year: 2024, Volume and Issue: 167(2), P. 231 - 249

Published: March 1, 2024

Language: Английский

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The Cancer Antioxidant Regulation System in Therapeutic Resistance

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 778 - 778

Published: June 27, 2024

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cells adeptly maintain elevated levels both ROS and antioxidants through process termed "redox reprogramming". This balance optimizes proliferative influence while simultaneously reducing potential for cause damage cell. some cases, adapted antioxidant machinery can hamper efficacy treatments neoplastic diseases, representing significant facet resistance mechanisms observed therapy. this review, we outline contribution systems therapeutic resistance. We detail fundamental constituents these systems, encompassing central regulatory involving transcription factors (of particular importance is KEAP1/NRF2 signaling axis), molecular effectors antioxidants, auxiliary responsible NADPH generation. Furthermore, present recent clinical trials based on targeted treatment cancer, assessing as well challenges strategy Additionally, summarize pressing issues field, with aim illuminating path toward emergence novel anticancer approaches by orchestrating redox signaling.

Language: Английский

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Mechanism of metal ion-induced cell death in gastrointestinal cancer

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116574 - 116574

Published: April 8, 2024

Gastrointestinal (GI) cancer is one of the most severe types cancer, with a significant impact on human health worldwide. Due to urgent demand for more effective therapeutic strategies against GI cancers, novel research metal ions treating cancers has attracted increasing attention. Currently, accumulating relationship between and therapy, several have been discovered induce cell death. In particular, three modes death, including ferroptosis, cuproptosis, calcicoptosis, become focal points in field cancer. Meanwhile, other also found trigger death through various mechanisms. Accordingly, this review focuses mechanisms ion-induced hoping provide theoretical support further therapies.

Language: Английский

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Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 26, 2025

Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.

Language: Английский

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