Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

The evidence regarding dietary antioxidant intake and all-cause cardiovascular disease (CVD) mortality among patients with hypertension is scarce. This study included 16,190 adults from the National Health Nutrition Examination Survey (NHANES) 1999–2018. Death outcomes were ascertained by linkage to Index records through December 31, 2019. Overall was estimated composite index (CDAI). Cox proportional hazards models used estimate risk for CVD mortality. Kaplan–Meier curve illustrate survival probabilities CDAI quartiles. Weighted quantile sum (WQS) regression conducted evaluate joint independent associations of antioxidants median (interquartile range) age participants 59.00 (47.00, 69.00) years. During a 94 months follow-up, 3,858 deaths documented. Compared lowest quartile CDAI, multivariable adjusted HR 95% CI highest 0.76 (0.64, 0.91) (Q4) vitamin E (HR = 0.69; CI, 0.59–0.80), selenium 0.84; 0.70–1.00) total carotenoids 0.86; 0.75–0.98) intakes negatively associated Vitamin might be major contributors this negative relationship. 0.72; 0.56–0.93) Higher overall significantly decreased hypertension. Further randomized controlled trials are required confirm our findings.

Language: Английский

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Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 688 - 688

Published: June 3, 2024

Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending underlying mechanisms developing strategies for prevention treatment. Selenium, crucial participant in redox reactions, emerges notable factor maintaining myocardial cell homeostasis influencing progression cardiovascular disorders. Some disorders, such Keshan disease, are directly linked with environmental deficiency. Nevertheless, precise extent system remains unclear, marked by contradictory findings existing literature. High selenium levels associated an increased risk hypertension, while lower concentrations heart failure atrial fibrillation. Although some trials shown potential effectiveness specific groups patients, large cohort supplementation attempts generally yielded unsatisfactory outcomes. Consequently, there persists significant need further research aimed at delineating patient cohorts that would benefit from supplementation.

Language: Английский

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Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 18, 2024

Intervertebral disc degeneration (IVDD) is a prevalent musculoskeletal disorder that involves the excessive accumulation of reactive oxygen species (ROS), resulting in mitochondrial dysfunction and matrix metabolism imbalance nucleus pulposus cells (NPCs). Selenium, an indispensable trace element, plays crucial role maintaining redox homeostasis by being incorporated into antioxidant selenoproteins as selenocysteine. In this study, we employed straightforward synthesis method to produce selenium nanoparticles (SeNPs) with consistent size distribution, evaluated their potential protective effects ameliorating IVDD. simulated inflammatory environment induced interleukin-1beta (IL-1β) vitro, SeNPs demonstrated effect on capacity NPCs through up-regulation aggrecan type II collagen, while concurrently suppressing expression degradation enzymes including MMP13 ADAMTS5. Additionally, preserved integrity restored impaired energy activating glutathione peroxidase1 (GPX1) rebalance homeostasis. rat lumbar model puncture, local administration hydration tissue, promoted deposition, effectively mitigated progression Our results indicate enhancement GPX1 may offer promising therapeutic approach for IVDD restoring function

Language: Английский

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Resveratrol improves diabetic kidney disease by modulating the gut microbiota-short chain fatty acids axis in db/db mice

International Journal of Food Sciences and Nutrition, Journal Year: 2024, Volume and Issue: 75(3), P. 264 - 276

Published: Jan. 18, 2024

Diabetic kidney disease is associated with the dysbiosis of gut microbiota and its metabolites. db/db mice were fed chow diet or without 0.4% resveratrol for 12 weeks, after which microbiota, faecal short-chain fatty acids (SCFAs), renal fibrosis analysed. Resveratrol ameliorated progression diabetic alleviated tubulointerstitial fibrosis. Further studies showed that was modulated by resveratrol, characterised expansion SCFAs-producing bacteria Faecalibaculum Lactobacillus, increased concentrations SCFAs (especially acetic acid) in faeces. Moreover, transplantation experiments found alteration contributed to prevention disease. Acetate treatment proteinuria, glomerulosclerosis mice. Overall, improved suppressing fibrosis, may be involved, at least part, regulation microbiota-SCFAs axis.

Language: Английский

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Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133812 - 133812

Published: Feb. 16, 2024

Language: Английский

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Selenium Decipher: Trapping of Native Selenomethionine-Containing Peptides in Selenium-Enriched Milk and Unveiling the Deterioration after Ultrahigh-Temperature Treatment

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(3), P. 1156 - 1166

Published: Jan. 8, 2024

Selenopeptide identification relies on databases to interpret the selenopeptide spectra. A common database search strategy is set selenium as a variable modification instead of sulfur peptides. However, this approach generally detects only fraction selenopeptides. An alternative approach, termed Selenium Decipher, proposed in present study. It involves identifying collision-induced dissociation-cleavable selenomethionine-containing peptides by iteratively matching masses seleno-amino acids This uses variable-data-independent acquisition (vDIA) for peptide detection, providing flexible and customizable window secondary mass spectral fragmentation. The attention mechanism was used capture global information determine backbones. core structure generates series fragment ions, namely, C3H7Se+, C4H10NSe+, C5H7OSe+, C5H8NOSe+, C7H11N2O2Se+, with known gaps during higher-energy collisional dissociation (HCD) De-selenium spectra are generated removing originating from replacement then reassigning precursors Selenium-enriched milk obtained feeding selenium-rich forage fed cattle, which leads formation native through biotransformation. novel antihypertensive Thr-Asp-Asp-Ile-SeMet-Cys-Val-Lys TDDI(Se)MCVK identified selenium-enriched milk. (IC50 = 60.71 μM) bound four active residues angiotensin-converting enzyme (ACE) pocket (Ala354, Tyr523, His353, His513) two zinc ligand (His387 Glu411) exerted competitive inhibitory effect spatial blocking sites. integration vDIA matched applied provides high validity identification.

Language: Английский

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Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E ₂ ‐Induced Oxidative Stress in Hypertension

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Background Prostaglandin E 2 (PGE ) in the rostral ventrolateral medulla (RVLM) has been recognized as a pivotal pressor substance hypertension, yet understanding of its effects and origins RVLM remains largely elusive. This study aimed to elucidate enzymes molecular mechanisms underlying PGE synthesis induced by central Ang II (angiotensin II) implications heightened oxidative stress sympathetic outflow hypertension. Methods Results microinjections Tempol were administered Wistar‐Kyoto rats. Intracisternal drug delivery adeno‐associated viral vectors microinjection used both rats spontaneous hypertensive modulate function II, receptor 3, expression COX2 (cyclooxygenase 2). Microinjection into significantly augmented activity (25.380±1.566%) level, whereas intracisternal infusion prostaglandin 3 antagonist attenuated II‐induced Furthermore, treatment upregulated neurons (1.000±0.112 versus 1.506±0.370 fold change), with no significant effect on other involved synthesis. Additionally, inhibition JAK2/STAT3 (Janus kinase 2/signal transducer activator transcription 3) signaling pathway nullified II‐mediated elevation expression, evidenced phosphorylated STAT3 binding sequence PC12 cells. Conclusions Central induces accumulation through neuronal AT1R type 1 receptor)/JAK2/STAT3/COX2 pathway, thereby promoting stress, augmenting outflow, contributing essential

Language: Английский

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A comprehensive review on selenium and blood pressure: recent advances and research perspectives

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127607 - 127607

Published: Jan. 1, 2025

Language: Английский

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Chemical analysis and angiotensin I-converting enzyme inhibitory activity of enzymatic hydrolysates derived from meat of goat-kids with supplemental selenium

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19261 - e19261

Published: April 22, 2025

Background The effects of selenium (Se) on animal health due to its antioxidant and immune system regulatory properties are very well-documented. However, there is still a lack scientific evidence about the effect Se muscle tissue. supplementation in ruminants will enhance activity myocytes increase angiotensin-converting enzyme (ACE) inhibitory activity. Generating bioactive peptides derived from meat could prevent production angiotensin II, key player development cardiovascular diseases. Methods Forty-five suckling goat kids were randomized into one three groups: (1) CG: group without supplemented diet; (2) GSS: with single injectable dose subcutaneously sodium selenite (Na 2 SeO 3 ) at 0.25 mg/kg body weight; (3) GSM: an oral administration selenomethionine (SeMe) 0.3 weight). both sources was evaluated proximate composition liver I-converting meat-derived enzymatic hydrolysates. Results kids-goat GSM had higher protein content ( p < 0.05). fat gradually increased over time treatment GSM, which ca. two-fold (from 1.77 3.68). degree hydrolysis samples decreased 0.05) treatments (GSS GSM). significantly electrophoretic patterns hydrolysates two h showed molecular weight between 23.44 27.5 kDa, bands more intensity. At 21 d slaughter, major observed GSM) compared CG. Meat rate ACE inhibition after improved (50% 2%, 7 slaughter. After hydrolysis, IC50 selenium-supplemented groups amount CAE values. Conclusion This first report describing goat-kids supplemental. These results indicate presence meat; however, percentage only dosing days study’s novelty indicates that synergized meat. It necessary continue these studies identify specific peptides, activities, meat’s biological functional value, considering it food can metabolic diseases be healthy alternative for human population.

Language: Английский

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Selenium corrects dysregulated mitophagy and lipophagy in obesity-related acute pancreatitis through the GPX1-Mfn2-PLIN2 axis

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 768, P. 151916 - 151916

Published: April 28, 2025

Language: Английский

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