IntechOpen eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 24, 2023
The
trace
element
selenium
is
crucial
for
cellular
defense
against
oxidative
stress
and
inflammatory
reactions.
Balanced
levels
are
important
the
vascular
system,
whereas
dysregulation
can
damage
reactivity.
Reports
have
also
supported
strong
relationship
between
inflammation,
which
induced
by
either
overproduction
of
reactive
oxygen
species
(ROS)
or
lack
antioxidant
proteins.
smooth
muscle
endothelium
layer
frequently
linked
to
disorders
such
as
hypertension,
hypercholesterolemia,
atherosclerosis.
Vascular
diseases
result
in
life-threatening
serious
cardiovascular
complications,
blood
clots,
heart
attack,
stroke.
Selenium
preventing
damage;
however,
low
extremely
high
amounts
intake
may
contribute
pathophysiology
disorders.
Selenoproteins
proteins
glutathione
peroxidase
containing
form
21st
amino
acid,
selenocysteine.
capacity
protect
lowering
harmful
ROS,
allows
them
regulate
normal
functions
including
vasoreactivity.
current
chapter’s
goal
was
carry
out
a
thorough
evaluation
literature
on
connection
Nutrition Journal,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 24, 2025
The
evidence
regarding
dietary
antioxidant
intake
and
all-cause
cardiovascular
disease
(CVD)
mortality
among
patients
with
hypertension
is
scarce.
This
study
included
16,190
adults
from
the
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2018.
Death
outcomes
were
ascertained
by
linkage
to
Index
records
through
December
31,
2019.
Overall
was
estimated
composite
index
(CDAI).
Cox
proportional
hazards
models
used
estimate
risk
for
CVD
mortality.
Kaplan–Meier
curve
illustrate
survival
probabilities
CDAI
quartiles.
Weighted
quantile
sum
(WQS)
regression
conducted
evaluate
joint
independent
associations
of
antioxidants
median
(interquartile
range)
age
participants
59.00
(47.00,
69.00)
years.
During
a
94
months
follow-up,
3,858
deaths
documented.
Compared
lowest
quartile
CDAI,
multivariable
adjusted
HR
95%
CI
highest
0.76
(0.64,
0.91)
(Q4)
vitamin
E
(HR
=
0.69;
CI,
0.59–0.80),
selenium
0.84;
0.70–1.00)
total
carotenoids
0.86;
0.75–0.98)
intakes
negatively
associated
Vitamin
might
be
major
contributors
this
negative
relationship.
0.72;
0.56–0.93)
Higher
overall
significantly
decreased
hypertension.
Further
randomized
controlled
trials
are
required
confirm
our
findings.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 688 - 688
Published: June 3, 2024
Cardiovascular
diseases
stand
as
the
predominant
global
cause
of
mortality,
exerting
a
profound
impact
on
both
life
expectancy
and
its
quality.
Given
their
immense
public
health
burden,
extensive
efforts
have
been
dedicated
to
comprehending
underlying
mechanisms
developing
strategies
for
prevention
treatment.
Selenium,
crucial
participant
in
redox
reactions,
emerges
notable
factor
maintaining
myocardial
cell
homeostasis
influencing
progression
cardiovascular
disorders.
Some
disorders,
such
Keshan
disease,
are
directly
linked
with
environmental
deficiency.
Nevertheless,
precise
extent
system
remains
unclear,
marked
by
contradictory
findings
existing
literature.
High
selenium
levels
associated
an
increased
risk
hypertension,
while
lower
concentrations
heart
failure
atrial
fibrillation.
Although
some
trials
shown
potential
effectiveness
specific
groups
patients,
large
cohort
supplementation
attempts
generally
yielded
unsatisfactory
outcomes.
Consequently,
there
persists
significant
need
further
research
aimed
at
delineating
patient
cohorts
that
would
benefit
from
supplementation.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 18, 2024
Intervertebral
disc
degeneration
(IVDD)
is
a
prevalent
musculoskeletal
disorder
that
involves
the
excessive
accumulation
of
reactive
oxygen
species
(ROS),
resulting
in
mitochondrial
dysfunction
and
matrix
metabolism
imbalance
nucleus
pulposus
cells
(NPCs).
Selenium,
an
indispensable
trace
element,
plays
crucial
role
maintaining
redox
homeostasis
by
being
incorporated
into
antioxidant
selenoproteins
as
selenocysteine.
In
this
study,
we
employed
straightforward
synthesis
method
to
produce
selenium
nanoparticles
(SeNPs)
with
consistent
size
distribution,
evaluated
their
potential
protective
effects
ameliorating
IVDD.
simulated
inflammatory
environment
induced
interleukin-1beta
(IL-1β)
vitro,
SeNPs
demonstrated
effect
on
capacity
NPCs
through
up-regulation
aggrecan
type
II
collagen,
while
concurrently
suppressing
expression
degradation
enzymes
including
MMP13
ADAMTS5.
Additionally,
preserved
integrity
restored
impaired
energy
activating
glutathione
peroxidase1
(GPX1)
rebalance
homeostasis.
rat
lumbar
model
puncture,
local
administration
hydration
tissue,
promoted
deposition,
effectively
mitigated
progression
Our
results
indicate
enhancement
GPX1
may
offer
promising
therapeutic
approach
for
IVDD
restoring
function
International Journal of Food Sciences and Nutrition,
Journal Year:
2024,
Volume and Issue:
75(3), P. 264 - 276
Published: Jan. 18, 2024
Diabetic
kidney
disease
is
associated
with
the
dysbiosis
of
gut
microbiota
and
its
metabolites.
db/db
mice
were
fed
chow
diet
or
without
0.4%
resveratrol
for
12
weeks,
after
which
microbiota,
faecal
short-chain
fatty
acids
(SCFAs),
renal
fibrosis
analysed.
Resveratrol
ameliorated
progression
diabetic
alleviated
tubulointerstitial
fibrosis.
Further
studies
showed
that
was
modulated
by
resveratrol,
characterised
expansion
SCFAs-producing
bacteria
Faecalibaculum
Lactobacillus,
increased
concentrations
SCFAs
(especially
acetic
acid)
in
faeces.
Moreover,
transplantation
experiments
found
alteration
contributed
to
prevention
disease.
Acetate
treatment
proteinuria,
glomerulosclerosis
mice.
Overall,
improved
suppressing
fibrosis,
may
be
involved,
at
least
part,
regulation
microbiota-SCFAs
axis.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(3), P. 1156 - 1166
Published: Jan. 8, 2024
Selenopeptide
identification
relies
on
databases
to
interpret
the
selenopeptide
spectra.
A
common
database
search
strategy
is
set
selenium
as
a
variable
modification
instead
of
sulfur
peptides.
However,
this
approach
generally
detects
only
fraction
selenopeptides.
An
alternative
approach,
termed
Selenium
Decipher,
proposed
in
present
study.
It
involves
identifying
collision-induced
dissociation-cleavable
selenomethionine-containing
peptides
by
iteratively
matching
masses
seleno-amino
acids
This
uses
variable-data-independent
acquisition
(vDIA)
for
peptide
detection,
providing
flexible
and
customizable
window
secondary
mass
spectral
fragmentation.
The
attention
mechanism
was
used
capture
global
information
determine
backbones.
core
structure
generates
series
fragment
ions,
namely,
C3H7Se+,
C4H10NSe+,
C5H7OSe+,
C5H8NOSe+,
C7H11N2O2Se+,
with
known
gaps
during
higher-energy
collisional
dissociation
(HCD)
De-selenium
spectra
are
generated
removing
originating
from
replacement
then
reassigning
precursors
Selenium-enriched
milk
obtained
feeding
selenium-rich
forage
fed
cattle,
which
leads
formation
native
through
biotransformation.
novel
antihypertensive
Thr-Asp-Asp-Ile-SeMet-Cys-Val-Lys
TDDI(Se)MCVK
identified
selenium-enriched
milk.
(IC50
=
60.71
μM)
bound
four
active
residues
angiotensin-converting
enzyme
(ACE)
pocket
(Ala354,
Tyr523,
His353,
His513)
two
zinc
ligand
(His387
Glu411)
exerted
competitive
inhibitory
effect
spatial
blocking
sites.
integration
vDIA
matched
applied
provides
high
validity
identification.
Journal of the American Heart Association,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Background
Prostaglandin
E
2
(PGE
)
in
the
rostral
ventrolateral
medulla
(RVLM)
has
been
recognized
as
a
pivotal
pressor
substance
hypertension,
yet
understanding
of
its
effects
and
origins
RVLM
remains
largely
elusive.
This
study
aimed
to
elucidate
enzymes
molecular
mechanisms
underlying
PGE
synthesis
induced
by
central
Ang
II
(angiotensin
II)
implications
heightened
oxidative
stress
sympathetic
outflow
hypertension.
Methods
Results
microinjections
Tempol
were
administered
Wistar‐Kyoto
rats.
Intracisternal
drug
delivery
adeno‐associated
viral
vectors
microinjection
used
both
rats
spontaneous
hypertensive
modulate
function
II,
receptor
3,
expression
COX2
(cyclooxygenase
2).
Microinjection
into
significantly
augmented
activity
(25.380±1.566%)
level,
whereas
intracisternal
infusion
prostaglandin
3
antagonist
attenuated
II‐induced
Furthermore,
treatment
upregulated
neurons
(1.000±0.112
versus
1.506±0.370
fold
change),
with
no
significant
effect
on
other
involved
synthesis.
Additionally,
inhibition
JAK2/STAT3
(Janus
kinase
2/signal
transducer
activator
transcription
3)
signaling
pathway
nullified
II‐mediated
elevation
expression,
evidenced
phosphorylated
STAT3
binding
sequence
PC12
cells.
Conclusions
Central
induces
accumulation
through
neuronal
AT1R
type
1
receptor)/JAK2/STAT3/COX2
pathway,
thereby
promoting
stress,
augmenting
outflow,
contributing
essential
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19261 - e19261
Published: April 22, 2025
Background
The
effects
of
selenium
(Se)
on
animal
health
due
to
its
antioxidant
and
immune
system
regulatory
properties
are
very
well-documented.
However,
there
is
still
a
lack
scientific
evidence
about
the
effect
Se
muscle
tissue.
supplementation
in
ruminants
will
enhance
activity
myocytes
increase
angiotensin-converting
enzyme
(ACE)
inhibitory
activity.
Generating
bioactive
peptides
derived
from
meat
could
prevent
production
angiotensin
II,
key
player
development
cardiovascular
diseases.
Methods
Forty-five
suckling
goat
kids
were
randomized
into
one
three
groups:
(1)
CG:
group
without
supplemented
diet;
(2)
GSS:
with
single
injectable
dose
subcutaneously
sodium
selenite
(Na
2
SeO
3
)
at
0.25
mg/kg
body
weight;
(3)
GSM:
an
oral
administration
selenomethionine
(SeMe)
0.3
weight).
both
sources
was
evaluated
proximate
composition
liver
I-converting
meat-derived
enzymatic
hydrolysates.
Results
kids-goat
GSM
had
higher
protein
content
(
p
<
0.05).
fat
gradually
increased
over
time
treatment
GSM,
which
ca.
two-fold
(from
1.77
3.68).
degree
hydrolysis
samples
decreased
0.05)
treatments
(GSS
GSM).
significantly
electrophoretic
patterns
hydrolysates
two
h
showed
molecular
weight
between
23.44
27.5
kDa,
bands
more
intensity.
At
21
d
slaughter,
major
observed
GSM)
compared
CG.
Meat
rate
ACE
inhibition
after
improved
(50%
2%,
7
slaughter.
After
hydrolysis,
IC50
selenium-supplemented
groups
amount
CAE
values.
Conclusion
This
first
report
describing
goat-kids
supplemental.
These
results
indicate
presence
meat;
however,
percentage
only
dosing
days
study’s
novelty
indicates
that
synergized
meat.
It
necessary
continue
these
studies
identify
specific
peptides,
activities,
meat’s
biological
functional
value,
considering
it
food
can
metabolic
diseases
be
healthy
alternative
for
human
population.