Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101147 - 101147
Published: Nov. 1, 2024
Language: Английский
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)
Published: March 1, 2025
According to reports, the inhibition of ferroptosis is an essential culprit malignant progression in various tumors, including colon cancer (CC). However, relevant study on regulatory mechanism CC sparse. This project was designed identify key genes modulating as well specific mechanisms. Based The Cancer Genome Atlas (TCGA)-CC mRNA expression data and immunohistochemistry assay, we analyzed ABCB6 SALL4 tissue. HTFtarget employed predict binding sites. cells by quantitative polymerase chain reaction, interaction between verified dual-luciferase chromatin immunoprecipitation experiments. Cell viability tested cell counting kit-8 colony formation assay. malondialdehyde (MDA), Fe2+ content, lipid reactive oxygen species (ROS) levels were examined utilizing corresponding reagent kits. protein ABCB6, SALL4, GPX4, GCLC, SLC3A2 determined via western blot. High detected CC. overexpression suppressed dramatically declined MDA, ROS, cells. Furthermore, it induced mitochondrial membrane potential dysfunction substantially fluorescence intensity GFP-LC3, which turn promoted proteins prevented ferroptosis. rescue experiment that initiated activation mediate mitophagy prevent findings evidenced SALL4/ABCB6 axis suppresses hinder pathway may be for regulate
Language: Английский
Citations
0
Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.
Language: Английский
Citations
0
Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156242 - 156242
Published: March 1, 2025
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156799 - 156799
Published: April 1, 2025
Language: Английский
Citations
0
Aging, Journal Year: 2024, Volume and Issue: unknown
Published: June 24, 2024
Chronic atrophic gastritis (CAG) is a chronic inflammatory disease and precancerous lesion in stomach cancer. Abnormal activation cellular ferroptosis further damages gastric tissue, which susceptible to inflammation. Luteolin has powerful anti-inflammatory regulatory potential for ferroptosis. We aimed clarify the involvement of luteolin inflammation during CAG. targets were searched identify intersecting genes database. The AGE-RAGE pathway target treatment binding site between RAGE was predicted through computer simulation molecular docking. established CAG rat model using N-methyl-N-nitro-N-nitroguanidine. therapeutic effect on detected western blotting, qPCR, hematoxylin eosin staining, lipid oxidation (MDA), Fe
Language: Английский
Citations
2
BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)
Published: July 12, 2024
Periapical lesions are characterized by periapical inflammation and damage to tissues eventually lead bone resorption even tooth loss. H2O2 is widely used in root canal therapy for patients with inflammation. Luteolin possesses high anti-inflammatory, antioxidant, anticancer potential. However, the underlying mechanism of efficacy luteolin on oxidative stress inflammatory tissue has not been previously addressed. We aimed investigate anti-inflammatory antioxidative effects H2O2-induced cellular After human osteoblasts (hFOB1.19) were treated lipopolysaccharide (LPS), luteolin, or H2O2, cell proliferation was analysed using a counting kit-8 (CCK-8), apoptosis measured flow cytometry, production reactive oxygen species (ROS) evaluated an oxidation-sensitive probe DCFH-DA ROS assay kit, expression genes proteins detected reverse transcription quantitative polymerase chain reaction (RT‒qPCR), Western blotting, enzyme-linked immunosorbent (ELISA). demonstrated that closely related level environment increased. inhibited increase interleukin-6 (IL-6), interleukin-8 (IL-8) tumour necrosis factor α (TNF-α) significantly repressed ROS, as well markedly strengthened superoxide dismutase (SOD) activity hFOB1.19 cells. Moreover, we may inhibit injury suppressing NF-κB pathway. elucidated protected from proinflammatory cytokines signalling Our findings provide potential drug treating periodontitis injury.
Language: Английский
Citations
2
Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108897 - 108897
Published: July 20, 2024
The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, shown that can impair learn memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore mechanisms Co-induced ferroptosis neurodegenerative damage both vivo vitro, focusing on regulation by N6-methyladenosine (m
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 1, 2024
Cancer is a serious public health problem in humans, and prevention control strategies are still necessary. Therefore, the development of new therapeutic drugs urgently needed. Targeting programmed cell death, particularly via induction cancer apoptosis, one treatment approaches employed. Recently, an increasing number studies have shown that compounds from natural plants can target death kill cells, laying groundwork for use future anticancer treatments. In this review, we focus on latest research progress role mechanism plant active ingredients different forms such as autophagy, necroptosis, ferroptosis, pyroptosis, to provide strong theoretical basis clinical antitumor drugs.
Language: Английский
Citations
1
Published: Jan. 1, 2024
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Language: Английский
Citations
0
The Journal of Toxicological Sciences, Journal Year: 2024, Volume and Issue: 49(9), P. 399 - 408
Published: Jan. 1, 2024
Nasopharyngeal carcinoma (NPC) originates from the nasopharynx epithelium, and luteolin is recognized as an important anti-cancer agent. This study investigated effects of on ferroptosis in NPC cells. cells were cultured exposed to varying concentrations luteolin. Cell viability, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione (GSH) Fe
Language: Английский
Citations
0