The Antioxidant Action of Astragali radix: Its Active Components and Molecular Basis

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1691 - 1691

Published: April 9, 2024

Astragali radix is a traditional medicinal herb with long history and wide application. It frequently used in prescriptions other materials to replenish Qi. According the classics of Chinese medicine, attributed properties such as Qi replenishing surface solidifying, sore healing muscle generating, inducing diuresis reduce edema. Modern pharmacological studies have demonstrated that some extracts active ingredients function antioxidants. The polysaccharides, saponins, flavonoids offer beneficial effects preventing controlling diseases caused by oxidative stress. However, there still lack comprehensive research on effective components molecular mechanisms through which exerts antioxidant activity. In this paper, we review radix; summarize content, bioavailability, mechanisms; reference for clinical application Astragalus future development novel

Language: Английский

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Comparative Metabolomics Analysis of Terpenoid and Flavonoid in Roots of Red Beet and Sugar Beet (Beta vulgaris L.)

Sugar Tech, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

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Acute kidney injury and energy metabolism

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 570, P. 120208 - 120208

Published: Feb. 20, 2025

Language: Английский

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Nebivolol rescued the liver and kidney from the coadministration of rivaroxaban and cisplatin by targeting inflammation, oxidative stress, and apoptosis in rats

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114486 - 114486

Published: March 19, 2025

Language: Английский

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Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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Dihydromyricetin protects against cisplatin-induced renal injury and mitochondria-mediated apoptosis via the EGFR/HSP27/STAT3 signaling pathway

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 14, 2025

Cisplatin (CP) has been used as an effective chemotherapy drug for different types of cancers. Despite its therapeutic benefits, the clinical utility CP is often hindered by adverse effects, notably acute kidney injury (AKI), which restricts widespread application. Dihydromyricetin (DHM) a flavonoid acquired from Ampelopsis grossedentata, exhibiting range pharmacological activities. The major objective this research was to examine possible molecular mechanism involved in CP-induced AKI and protective function DHM. In study, DHM against assessed both mice HK-2 cells. Kidney dysfunction parameters renal morphology were evaluated ascertain extent protection. Additionally, proteomics techniques employed investigate effect elucidate underlying mechanisms mitigating AKI. addition, protein levels epidermal growth factor receptor (EGFR), p-EGFR, heat shock 27 (HSP27), p-HSP27, STAT3, p-STAT3 tissues investigated. Furthermore, EGFR-blocking agent (gefitinib) or si-RNA HSP27 study effects inhibiting EGFR on injury. decreased blood urea nitrogen (BUN) creatinine serum, alleviated morphological downregulated expression molecule-1 neutrophil gelatinase-related lipocalin. Proteomic data revealed potential target treatment resulted downregulation EGFR, HSP27, STAT3 phosphorylation, ultimately inhibition reduced mitochondria-mediated apoptosis cell damage effectively inhibited oxidative stress, inflammation, through EGFR/HSP27/STAT3 pathway.

Language: Английский

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Remodeling the Neuroimmune Microenvironment in Retinal Ischemia‐Reperfusion Injury via Combined CRISPR/Cas9 Targeting of ACSL4 and Isorhamnetin

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Retinal ischemia‐reperfusion (RIR) injury induces oxidative stress, excitotoxicity, inflammation, and ferroptosis, which interact through complex crosstalk, forming a retinal pathological microenvironment (RPMe) that drives ganglion cell (RGC) death. Central to these processes is the dysregulation of neuroimmune (NiMe), characterized by aberrant microglial activation around RGCs immune signaling imbalances. Here, analysis single‐cell RNA sequencing, it identifies significant sphingolipid pathway in RIR‐injured microglia, crosstalks with pathways. This crosstalk disrupts NiMe homeostasis. To address this, biomimetic nanoparticle system coated precursor membranes developed. co‐delivers CRISPR/Cas9‐based Acyl‐CoA synthetase long‐chain family member 4 (ACSL4) inhibitor suppress ferroptosis isorhamnetin, natural molecule identified directly bind protein kinase A inhibit glutamatergic synapse involved stress. By targeting its PI3K/AKT ASK1/JNK/NF‐κB pathways as well RGCs, this restores balance. The membrane‐coated offers novel, synergistic, targeted therapeutic strategy for RIR‐related diseases integrating CRISPR/Cas9 technology product therapy.

Language: Английский

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Nephropathy induced by cisplatin results from mitochondrial disruption, impaired energy metabolism, altered expression of renal transporters, and accumulation of urinary toxins

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127553 - 127553

Published: Oct. 18, 2024

Language: Английский

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Platinum-based chemotherapies-induced nephrotoxicity: mechanisms, potential treatments, and management

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

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