Traumatic Brain Injury from a Peripheral Axis Perspective: uncovering the roles of liver and adipose tissue in temperature regulation DOI Creative Commons
Fernando Gómez‐Pinilla,

Sydney. K. Myers

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: 247, P. 102733 - 102733

Published: March 1, 2025

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Most current treatments for TBI other neurological disorders focus on the brain, often overlooking significant contributions peripheral organs to disease progression. Emerging evidence suggests that such as liver adipose tissue play crucial roles in pathogenesis. The synthesizes lipids proteins vital function, while provides hormones metabolites influence activity. New research indicates work concert with hypothalamus regulate essential processes, body temperature, which become disrupted TBI. Additionally, brain-peripheral axis-a complex network visceral nerve pathways, hormones, metabolites-plays bidirectional role regulating plasticity function. Understanding how leads dysregulation liver, tissue, could unlock new therapeutic opportunities treating related disorders. intricate autonomic involving hypothalamic enteric neurons, along pathways presents both pathological targets potential. We examine scientific suggesting correcting disturbances systemic physiology enhance brain's capacity healing. However, interdependence this implies dysfunction one area may affect others. Therefore, we also explore mechanisms by diet exercise can comprehensively impact axis, supporting healing process. CHEMICAL COMPOUNDS: D-Fructose (PubChem CID 2723872); docosahexaenoic acid 45934466); eicosapentaenoic 5282847).

Language: Английский

Epigenetics-targeted drugs: current paradigms and future challenges DOI Creative Commons

Wanlin Dai,

Xinbo Qiao, Yuanyuan Fang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 26, 2024

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.

Language: Английский

Citations

25
Identification of Potential Intervention Targets Involved in Prior Exercise that Attenuates Peripheral Neuropathic Pain by Integrating Transcriptome and Whole-genome Bisulfite Sequencing Analyses DOI
Binglin Chen, Ting Wang,

Chenchen Zhu

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

0
Traumatic Brain Injury from a Peripheral Axis Perspective: uncovering the roles of liver and adipose tissue in temperature regulation DOI Creative Commons
Fernando Gómez‐Pinilla,

Sydney. K. Myers

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: 247, P. 102733 - 102733

Published: March 1, 2025

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Most current treatments for TBI other neurological disorders focus on the brain, often overlooking significant contributions peripheral organs to disease progression. Emerging evidence suggests that such as liver adipose tissue play crucial roles in pathogenesis. The synthesizes lipids proteins vital function, while provides hormones metabolites influence activity. New research indicates work concert with hypothalamus regulate essential processes, body temperature, which become disrupted TBI. Additionally, brain-peripheral axis-a complex network visceral nerve pathways, hormones, metabolites-plays bidirectional role regulating plasticity function. Understanding how leads dysregulation liver, tissue, could unlock new therapeutic opportunities treating related disorders. intricate autonomic involving hypothalamic enteric neurons, along pathways presents both pathological targets potential. We examine scientific suggesting correcting disturbances systemic physiology enhance brain's capacity healing. However, interdependence this implies dysfunction one area may affect others. Therefore, we also explore mechanisms by diet exercise can comprehensively impact axis, supporting healing process. CHEMICAL COMPOUNDS: D-Fructose (PubChem CID 2723872); docosahexaenoic acid 45934466); eicosapentaenoic 5282847).

Language: Английский

Citations

0