Research progress of early brain Injury in subarachnoid hemorrhage from 2004 to 2024: a bibliometric analysis

Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)

Published: Jan. 23, 2025

Language: Английский

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Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

Ferroptosis is a distinct form of cell death characterized by iron-dependent lipid peroxidation and plays crucial role in the early brain injury (EBI) following subarachnoid hemorrhage (SAH). As newly discovered endogenous ligand for C-KIT receptor tyrosine kinase, meteorin-like protein (Metrnl) exerts regulatory functions oxidative stress protects against various diseases. However, specific Metrnl/C-KIT axis neuronal ferroptosis during EBI SAH remains to be elucidated. Sprague Dawley rats were used establish model through endovascular perforation. r-Metrnl was administered intranasally 1 h after SAH. Metrnl shRNA, inhibitor ISCK03, AMPK dorsomorphin, Nrf2 ML385 intracerebroventricularly or intraperitoneally before treatment explore underlying mechanisms. Neurobehavioral assessments, immunofluorescence, western blot, ELISA, Fluoro-Jade C staining, transmission electron microscopy, Nissl staining conducted evaluate effects. Additionally, primary neuron culture with hemoglobin (Hb) stimulation vitro studies. Phosphorylated levels upregulated Knockdown aggravated neurobehavioral deficits ferroptosis, whereas showed protective effect. Mechanistically, significantly increased SLC7A11, GPX4, FTH, FSP1, GSH, it decreased ACSL4, 4HNE, MDA ipsilateral hemisphere 24 Also, reduced mitochondrial shrinkage, crista, membrane density. beneficial effects partially reversed both vivo vitro. Our study demonstrated that improved neurological outcomes modulating C-KIT/AMPK/Nrf2 signaling pathway.

Language: Английский

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Gene expression changes in human cerebral arteries following hemoglobin exposure: implications for vascular responses in SAH

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Subarachnoid hemorrhage (SAH), characterized by the presence of hemoglobin (Hb) in subarachnoid space, significantly impacts cerebral vessels, leading to various pathological outcomes. The toxicity cell-free Hb released from erythrocytes and its metabolites after SAH causes vasoconstriction neuronal damage, correlates with delayed ischemic neurological deficits (DIND). While animal models have provided substantial invaluable data research aneurysmal SAH, specific effects blood on arteries remain greatly understudied. Here, we describe changes genetic profile human exposed free for 48 h. We performed an ex vivo exposure, followed mRNA sequencing vessels. Compared controls 54 genes were downregulated, 53 upregulated exposure. Enrichment analysis identified ferroptosis pathway as most affected. Further lipid peroxidation (LPO) assays elevated ACSL4 gene expression support a pathway. Additionally, exposure altered key signaling pathways essential vascular stability (PI3K-Akt, MAPK), modified G-protein mediated RGS1/2, suppressed transcription factors such KLF5, NR4A1, FOS. Our results underscore critical role driving responses brain Furthermore, our dataset could be valuable developing interventions may help identify underlying injury.

Language: Английский

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SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 7, 2025

Language: Английский

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Ginsenoside Rd alleviates early brain injury by inhibiting ferroptosis through cGAS/STING/DHODH pathway after subarachnoid hemorrhage

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Fighting ferroptosis: Protective effects of dexmedetomidine on vital organ injuries

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122949 - 122949

Published: Aug. 8, 2024

Language: Английский

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