Sepsis-Induced Endothelial Dysfunction: Permeability and Regulated Cell Death DOI Creative Commons

Wei Zhang,

Luofeng Jiang, Xirui Tong

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9953 - 9973

Published: Nov. 1, 2024

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Endothelial cells (ECs) are an important cell type typically affected in sepsis, resulting compromised barrier function and various forms of regulated death (RCD). However, the precise mechanisms underlying sepsis-induced EC damage remain unclear. This review summarizes recent research progress on factors that may affect permeability RCD ECs under septic conditions, including glycocalyx, damage-associated molecular patterns, ECs, such as apoptosis, pyroptosis, ferroptosis, autophagy. offers insights into endothelial aiming contribute developing small-molecule targeted clinical therapies.

Language: Английский

Metallothionein rescues doxorubicin cardiomyopathy via mitigation of cuproptosis DOI
Yan Liu, Mingzhi Shen,

Shuyi Zhu

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 363, P. 123379 - 123379

Published: Jan. 8, 2025

Language: Английский

Citations

0
Oxidative stress and inflammation combine to exacerbate cochlear damage and sensorineural hearing loss in C57BL/6 mice DOI Creative Commons
Zhongwu Su, Yuyan Chen, Yu Liu

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 5, 2025

Sensorineural hearing loss (SNHL) is among the most common sensory disorders, significantly affecting various aspects of quality life an individual. Oxidative stress and inflammation have been involved in progression forms SNHL are potential pathological mechanisms disorder. However, synergistic effects oxidative on cochlear function not completely understood. We explored damage impairment male C57BL/6 mice aged 6 to 7 weeks. These experimental group were administered with oxidant Menadione bisulfite (MD) endotoxin lipopolysaccharide (LPS) via intraperitoneal route induce inflammation, whereas control received saline. The degree was analyzed based auditory thresholds, hair cells (HCs) loss, expression protein markers related stress, necroptosis, ferroptosis. After six days alternating MD LPS injections, there a notable elevation which associated substantial HCs spiral ganglion cells. Immunofluorescence analysis demonstrated activation ferroptosis signaling pathways after treatment. Notably, administration either or alone did result significant changes. findings indicate that interaction between may exacerbate contribute potentially through necroptosis pathways. Our results identify therapeutic targets for management SNHL.

Language: Английский

Citations

0
Ferroptosis targeting offers a Therapeutic Target for Septic cardiomyopathy DOI

Ping Zhou,

Mengxue Liu, Tao Lv

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102930 - 102930

Published: April 25, 2025

Language: Английский

Citations

0
Sepsis-Induced Endothelial Dysfunction: Permeability and Regulated Cell Death DOI Creative Commons

Wei Zhang,

Luofeng Jiang, Xirui Tong

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9953 - 9973

Published: Nov. 1, 2024

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Endothelial cells (ECs) are an important cell type typically affected in sepsis, resulting compromised barrier function and various forms of regulated death (RCD). However, the precise mechanisms underlying sepsis-induced EC damage remain unclear. This review summarizes recent research progress on factors that may affect permeability RCD ECs under septic conditions, including glycocalyx, damage-associated molecular patterns, ECs, such as apoptosis, pyroptosis, ferroptosis, autophagy. offers insights into endothelial aiming contribute developing small-molecule targeted clinical therapies.

Language: Английский

Citations

0