The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications DOI Creative Commons

Xiaojun Fei,

Chao Song, Jian Cui

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Cardiovascular diseases (CVDs) have become the leading cause of death globally, surpassing infectious and other chronic illnesses. The incidence mortality rates CVDs are rising worldwide, posing a key challenge in public health. ubiquitination system is vast complex. It an important post-translational modification that plays crucial role various cellular processes. Deubiquitination catalyzed by deubiquitinases (DUBs), which remove ubiquitin (Ub) from ubiquitinated proteins, thereby reversing process. DUBs play many biological processes, such as DNA repair, cell metabolism, differentiation, epigenetic regulation, protein stability control. They also participate regulation signaling pathways associated with development progression CVDs. In this review, we primarily focus on pathological mechanisms atherosclerosis (AS), foam formation, vascular remodeling (VR), endothelial-to-mesenchymal transition (End-MT), clonal hematopoiesis (CH). heart, summarize involvement including heart failure (HF), myocardial infarction (MI), hypertrophy (MH) ischemia/reperfusion (I/R) injury. Additionally, explore diabetic cardiomyopathy (DCM) use doxorubicin-induced cardiotoxicity clinical settings. A comprehensive understanding deubiquitination may provide new insights for treatment drug design

Language: Английский

The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications DOI Creative Commons

Xiaojun Fei,

Chao Song, Jian Cui

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Cardiovascular diseases (CVDs) have become the leading cause of death globally, surpassing infectious and other chronic illnesses. The incidence mortality rates CVDs are rising worldwide, posing a key challenge in public health. ubiquitination system is vast complex. It an important post-translational modification that plays crucial role various cellular processes. Deubiquitination catalyzed by deubiquitinases (DUBs), which remove ubiquitin (Ub) from ubiquitinated proteins, thereby reversing process. DUBs play many biological processes, such as DNA repair, cell metabolism, differentiation, epigenetic regulation, protein stability control. They also participate regulation signaling pathways associated with development progression CVDs. In this review, we primarily focus on pathological mechanisms atherosclerosis (AS), foam formation, vascular remodeling (VR), endothelial-to-mesenchymal transition (End-MT), clonal hematopoiesis (CH). heart, summarize involvement including heart failure (HF), myocardial infarction (MI), hypertrophy (MH) ischemia/reperfusion (I/R) injury. Additionally, explore diabetic cardiomyopathy (DCM) use doxorubicin-induced cardiotoxicity clinical settings. A comprehensive understanding deubiquitination may provide new insights for treatment drug design

Language: Английский

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