Non-Integrin Laminin Receptors: Shedding New Light and Clarity on Their Involvement in Human Diseases DOI Open Access
Filomena Napolitano,

Miriana Fabozzi,

Nunzia Montuori

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3546 - 3546

Published: April 10, 2025

The extracellular matrix (ECM) is a dynamic network of macromolecules that provides structural support for cells and orchestrates cell signaling, functions, morphology. basement membrane constitutes peculiar sheet-like type ECM located between epithelial tissues underlying connective tissues. major constituent the laminin, which exerts remarkable repertoire biological functions such as differentiation, migration, adhesion, wound healing. Laminin performs its by interacting with two main classes receptors, integrin non-integrin laminin creating complex essential tissue integrity regeneration. Dysfunctional actions are cause diverse human diseases, including cancer, infectious, neurodegenerative diseases. This topic has attracted researchers some time, but diversity cell-surface through signaling occurs, makes role controversial. Moreover, different isoforms were identified, each specific differs from others in their composition. review focuses on molecular basis pathophysiological relevance interactions laminins receptors development, health, disease.

Language: Английский

Non-Integrin Laminin Receptors: Shedding New Light and Clarity on Their Involvement in Human Diseases DOI Open Access
Filomena Napolitano,

Miriana Fabozzi,

Nunzia Montuori

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3546 - 3546

Published: April 10, 2025

The extracellular matrix (ECM) is a dynamic network of macromolecules that provides structural support for cells and orchestrates cell signaling, functions, morphology. basement membrane constitutes peculiar sheet-like type ECM located between epithelial tissues underlying connective tissues. major constituent the laminin, which exerts remarkable repertoire biological functions such as differentiation, migration, adhesion, wound healing. Laminin performs its by interacting with two main classes receptors, integrin non-integrin laminin creating complex essential tissue integrity regeneration. Dysfunctional actions are cause diverse human diseases, including cancer, infectious, neurodegenerative diseases. This topic has attracted researchers some time, but diversity cell-surface through signaling occurs, makes role controversial. Moreover, different isoforms were identified, each specific differs from others in their composition. review focuses on molecular basis pathophysiological relevance interactions laminins receptors development, health, disease.

Language: Английский

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