Cold atmospheric plasma control metabolic syndromes via targeting fat mass and obesity-associated protein DOI Creative Commons
Xiaofeng Dai, Shuo Feng, Tian Li

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107720 - 107720

Published: March 1, 2025

Both obesity and metabolic disorders are global medical problems. Driven by prolonged inflammation, increases the risk of developing syndromes such as fatty liver, diabetes, cardiovascular diseases cancers. The fat mass obesity-associated protein (FTO) is an m6A demethylase, elevated activity which known to promote pathogenesis many disorders, leading establishment various FTO inhibitors. By combing through intrinsic connections among four primary problems, we attribute their shared pathological cause inflammation. reviewing roles in promoting these current status existing inhibitors treating syndromes, underpinned paramount potential resolving clinical issues targeting urgent need establishing novel with maximized efficacy minimized side effect. Cold atmospheric plasma (CAP) fourth state matter demonstrated associated chronic introducing characteristics CAP, proposed it a possible solution unresolved given its anti-inflammation feature safety. We also emphasized intensive investigations exploring feasibility using CAP that might function FTO.

Language: Английский

Cold atmospheric plasma control metabolic syndromes via targeting fat mass and obesity-associated protein DOI Creative Commons
Xiaofeng Dai, Shuo Feng, Tian Li

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107720 - 107720

Published: March 1, 2025

Both obesity and metabolic disorders are global medical problems. Driven by prolonged inflammation, increases the risk of developing syndromes such as fatty liver, diabetes, cardiovascular diseases cancers. The fat mass obesity-associated protein (FTO) is an m6A demethylase, elevated activity which known to promote pathogenesis many disorders, leading establishment various FTO inhibitors. By combing through intrinsic connections among four primary problems, we attribute their shared pathological cause inflammation. reviewing roles in promoting these current status existing inhibitors treating syndromes, underpinned paramount potential resolving clinical issues targeting urgent need establishing novel with maximized efficacy minimized side effect. Cold atmospheric plasma (CAP) fourth state matter demonstrated associated chronic introducing characteristics CAP, proposed it a possible solution unresolved given its anti-inflammation feature safety. We also emphasized intensive investigations exploring feasibility using CAP that might function FTO.

Language: Английский

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