Association fasting blood sugar to high-density lipoprotein cholesterol ratio and hypertension: Analysis from the National Health and Nutrition Examination Survey (2003– 2018)
Abstract
Hypertension
is
a
chronic
disease
that
poses
significant
threat
to
human
health
worldwide.
The
ratio
of
fasting
blood
sugar
high-density
lipoprotein
cholesterol
(GHR)
an
emerging
biomarker
associated
with
various
diseases.
However,
the
relationship
between
GHR
and
hypertension
was
still
unclear.
This
study
aimed
explore
correlation
high
pressure.
conducted
comprehensive
cross-sectional
analysis
based
on
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2003
2018.
used
multivariate
logistic
regression
model
evaluate
hypertension.
It
also
verified
robustness
results
through
subgroup
analysis.
In
addition,
restricted
cubic
splines
(RCS)
analyze
possible
nonlinear
hypertension,
as
well
potential
threshold
effects.
Finally,
evaluated
predictive
efficiency
for
receiver
operating
characteristic
(ROC)
curve
showed
that,
without
adjusting
confounding
factors,
positively
correlated
(OR
=
1.20,
95%CI
1.17–1.22,
P
<
0.001).
After
fully
factors
(including
gender,
race,
age,
body
mass
index,
smoking
status,
alcohol
consumption,
diabetes,
stroke,
total
cholesterol,
creatinine),
positive
existed
1.06,
1.03–1.09,
Subgroup
further
association
remained
consistent
across
different
subgroups.
ROC
revealed
turning
point
2.36.
Furthermore,
indicated
demonstrated
in
univariate
multivariate-adjusted
models.
A
had
serve
biological
marker
facilitating
its
prevention
diagnosis.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 29, 2025
Language: Английский