Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4823 - 4823

Published: Nov. 17, 2023

In light of the constantly increasing prevalence allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for development and progression these diseases. Nowadays, much attention has paid to interventions using natural substances with anti-allergy activities. this respect, polyphenols studied extensively one most prominent bioactive compounds well-documented anti-inflammatory, antioxidant, immunomodulatory properties. This review aims discuss mechanisms underlying potential anti-allergic actions related their ability reduce protein allergenicity, regulate immune response, gut microbiome modification; however, issues need be elucidated detail. paper reviews current evidence from experimental clinical studies confirming that various such quercetin, curcumin, resveratrol, catechins, many others could attenuate inflammation, alleviate symptoms food allergy, asthma, rhinitis, prevent response. Conclusively, are endowed great therefore used either preventive approaches or therapeutic relation Limitations studying widespread use well future research directions also discussed.

Language: Английский

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Se-rich tea polysaccharide extracted by high hydrostatic pressure attenuated anaphylaxis by improving gut microbiota and metabolic regulation

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132128 - 132128

Published: May 7, 2024

Language: Английский

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Notch Signaling Inhibition Alleviates Allergies Caused by Antarctic Krill Tropomyosin through Improving Th1/Th2 Imbalance and Modulating Gut Microbiota

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1144 - 1144

Published: April 9, 2024

Antarctic krill tropomyosin (AkTM) has been shown in mice to cause IgE-mediated food allergy. The objective of this work was investigate the role Notch signaling AkTM-sensitized mice, as well determine changes gut microbiota composition and short-chain fatty acids (SCFAs) allergic mice. An AkTM-induced allergy mouse model built N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) used an γ-secretase inhibitor inhibit activation signaling. Food indices, some key transcription factors, histologic alterations small intestine, were examined. results showed that DAPT inhibited signaling, which reduced AkTM-specific IgE, suppressed mast cell degranulation, decreased IL-4 but increased IFN-γ production, alleviated symptoms. Quantitative real-time PCR Western blotting analyses revealed expressions Hes-1, Gata3, down-regulated after treatment, accompanied by increases T-bet IFN-γ, indicating active blocking it could reverse Th1/Th2 imbalance. Expressions factors promote Th2 differentiation sensitized Furthermore, 16S rRNA sequencing AkTM alter diversity leading inflammation-inducing bacteria such Enterococcus Escherichia-Shigella. Correlation analysis indicated SCFA concentrations AkTM-allergic may be related decreases certain SCFA-producing bacteria, Clostridia_UCG-014. SCFAs partially restored treatment. Our findings inhibiting alleviate correcting imbalance modulating microbiota.

Language: Английский

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Engineered inulin-based hybrid biomaterials for augmented immunomodulatory responses

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 340, P. 122311 - 122311

Published: May 23, 2024

Language: Английский

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Human milk oligosaccharides 2’-fucosyllactose and 3-fucosyllactose attenuate ovalbumin–induced food allergy through immunoregulation and gut microbiota modulation

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The prebiotic properties of human milk oligosaccharides (HMOs) and emerging evidence immunomodulatory effects suggest their potential therapeutic value in allergy management. 2'-Fucosyllactose (2'-FL) has been reported to alleviate food allergies, while the effect other fucosylated HMOs on remains unclear. In this study, we assess two HMOs, 2'-FL 3-fucosyllactose (3-FL), symptomatology immunological responses an ovalbumin (OVA)-sensitized mouse model as well influence gut microbiota. assessment allergic symptoms, specific immunoglobulin E (IgE), related gene expression levels sensitized mice indicated that 3-FL was effective alleviating allergy. significantly decreased serum OVA-specific IgE, mast cell protease (mMCP-1) IL-4 increasing IFN-γ. Additionally, down-regulated allergy-related cytokines small intestine improved intestinal barrier damage. Furthermore, both treatment positively influenced microbial profiles, particular by enhancing proportion beneficial bacteria such Lactobacillus Bifidobacterium decreasing percentage Turicibacter Lachnospiraceae NK4A136 group, thereby modulating immune system. Therefore, study can provide insights into OVA-induced

Language: Английский

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Co-microencapsulation of Lactobacillus paracasei and Inonotus obliquus polysaccharide in alginate system: physicochemical and functional properties

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111344 - 111344

Published: March 1, 2025

Language: Английский

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Pea protein sensitization: insights from allergy model experiment in BALB/c mice

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106357 - 106357

Published: March 1, 2025

Language: Английский

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Allergenicity of Alternative Proteins: Reduction Mechanisms and Processing Strategies

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The increasing popularity of alternative proteins has raised concerns about allergenic potential, especially for plant-, insect-, fungal-, and algae-based proteins. Allergies arise when the immune system misidentifies as harmful, triggering IgE-mediated reactions that range from mild to severe. Main factors influencing allergenicity include protein structure, cross-reactivity, processing methods, gut microbiota. Disruptions in health or microbiota balance heighten risks. Common allergens legumes, cereals, nuts, oilseeds, single-cell proteins, insect-based are particularly challenging, they often remain stable resistant heat digestion despite various techniques. Processing such roasting, enzymatic hydrolysis, fermentation, show promise reducing by altering structures breaking down epitopes trigger responses. Future research should focus on optimizing these methods ensure effectively reduce risks while maintaining nutritional quality safety products.

Language: Английский

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Dietary AGEs and food allergy: insights into the mechanisms of AGEs-induced food allergy and mitigation strategies

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 24, 2025

Food allergy (FA) is a significant public health concern, with over one billion individuals globally affected, and its prevalence continues to rise. Advanced glycation end products (AGEs) are common hazards in various diet. Recent investigations have shown that AGEs could influence the pathogenesis of FA by interacting receptors. This paper provides comprehensive review recent advances on diet AGEs, summarized mechanisms regulating food mitigation strategies, analyzed limitations current research prospected future research. combine receptors for (RAGE) induce oxidative stress, inflammation allergic signaling pathways. can affect allergen epitopes conformation regulate intestinal flora non-receptor-dependent manner, as well barrier Th1/Th2 immune balance through receptor-dependent pathways allergy. Currently, approaches reduce AGEs-induced mainly depended improving processing methods (e.g., low temperature, short time, pH non-thermal methods), natural inhibitors RAGE inhibitors. elucidates influences which provide novel insights into reducing induced AGEs.

Language: Английский

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Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Food allergy (FA) has received increased attention in recent years. Multiple studies have highlighted the crucial role of short‐chain fatty acids (SCFAs) development IgE‐mediated FA. Here, a case‐control approach was employed to analyze SCFAs profiles children with FA, while an ovalbumin (OVA)‐sensitized mouse model utilized explore underlying mechanism by which mitigate Children food‐sensitized tolerance (FST) ( n = 20) or FA 20), and healthy controls (HC) were recruited profiles. The HC group exhibited higher levels fecal samples than FST, FST + groups. Data from OVA‐sensitized showed that butyrate more significant effect on reducing allergic reactions compared other SCFAs. Compared negative control group, OVA‐induced oxidative stress (OS) triggered excessive Notch signaling activation, subsequently impaired both tight junctions integrity mucosal barrier function murine intestinal epithelial cells (IECs). Gut dysbiosis induced mucus layer erosion, thereby elevating IECs exposure food antigens OS, potentiated activation. However, counteracted this loop restoring microbiota structure suppressing reactive oxygen species (ROS)/Notch cascades. Strikingly, low‐dose (0.25–1 mM) protected rat small intestine crypt (IEC‐6) inhibiting ROS, whereas high‐dose (2–5 exacerbated injury activation signaling. Our study revealed potential molecular mechanisms through alleviates allergy, providing therapeutic strategy for its management.

Language: Английский

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