Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance DOI Creative Commons

Karina Hissen,

Wenliang He, Guoyao Wu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 29, 2023

Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because their biochemical and physiological similarity to humans. Presently, there has been an interest using teleost fish study intestinal immunology, particularly mucosa response. Instead targeting the pathogen itself, a preferred approach for managing health is through nutrient supplementation, as it noninvasive less labor intensive than vaccine administrations while still modulating properties. Amino acids (AAs) regulate metabolic processes, oxidant-antioxidant balance, requirements improve Thus, nutritionists can develop sustainable aquafeeds AA supplementation promote specific responses, including system. We propose use dietary with functional AAs response by discussing immunology within intestine explore how oxidative burst used defense mechanism. evaluate components responses that balance potential selection metabolites mucosal capacity gut integrity. effective modulators immunity balance. To incorporate nutrition immunoregulatory means teleost, we must obtain more tools genomic, proteomic, nutrition, macrobiotic metabonomic analyses, so future provide holistic understanding system fish.

Language: Английский

Multi-omics analysis of miRNA-mediated intestinal microflora changes in crucian carp Carassius auratus infected with Rahnella aquatilis DOI Creative Commons

Jiaxin Huo,

Xiaowei Li,

Xiucai Hu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 15, 2024

Infection by an emerging bacterial pathogen Rahnella aquatilis caused enteritis and septicemia in fish. However, the molecular pathogenesis of induced R. infection its interacting mechanism intestinal microflora associated with microRNA (miRNA) immune regulation crucian carp Carassius auratus are still unclear. In this study, C. intraperitoneally injected KCL-5 was used as experimental animal model, pathological changes, microflora, differentially expressed miRNAs (DEMs) were investigated multi-omics analysis. The significant changes histopathological features, apoptotic cells, enzyme activities (e.g., lysozyme (LYS), alkaline phosphatase (AKP), alanine aminotransferase (ALT), aspartate transaminase (AST), glutathione peroxidase (GSH-Px)) intestine examined after infection. Diversity composition analysis clearly demonstrated four dominant bacteria: Proteobacteria, Fusobacteria, Bacteroidetes, Firmicutes. A total 87 DEMs significantly screened, Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses revealed that potential target genes mainly involved lipid, glutathione, cytosine, purine metabolism, which participated local response through network for IgA production, lysosome, Toll-like receptor (TLR) pathways. Moreover, expression levels 11 TLR3, MyD88, NF-κB, TGF-β, TNF-α, MHC II, IL-22, LysC, F2, F5, C3) related to inflammation immunity verified qRT-PCR detection. correlation indicated abundance Firmicutes Proteobacteria high miR-203/NF-κB, miR-129/TNF-α, miR-205/TGF-β. These findings will help elucidate inflammation, response-mediated miRNA-target gene axis cyprinid

Language: Английский

Citations

3
Modulation of metabolic and immunoregulatory pathways in the gut transcriptome of Atlantic salmon (Salmo salar L.) after early nutritional programming during first feeding with plant-based diet DOI Creative Commons

Marwa Mamdouh Tawfik,

Mónica B. Betancor, Stuart McMillan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 2, 2024

Plant-based nutritional programming is the concept of exposing fish at very early life stages to a plant-based diet for short duration improve physiological responses when exposed similar plant-rich later developmental stage. The mechanisms action underlying have not been fully deciphered, and may be controlled multiple levels.

Language: Английский

Citations

3
CD3γ/δ+ T cells and MSCFR+ macrophages are activated to produce IL-26 after bacterial infection in grass carp DOI

Teng Xie,

Yibin Yang,

Kangyong Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110185 - 110185

Published: Feb. 1, 2025

Language: Английский

Citations

0
Oral pcDNA3.1-VP4/VP56-FlaC DNA vaccine encapsulated by chitosan/sodium alginate nanoparticles confers remarkable protection against GCRV infection in grass carp DOI

Xingchen Huo,

Lingjie Tang, Qian Liu

et al.

Aquaculture, Journal Year: 2023, Volume and Issue: 577, P. 739996 - 739996

Published: Aug. 15, 2023

Language: Английский

Citations

8
Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance DOI Creative Commons

Karina Hissen,

Wenliang He, Guoyao Wu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 29, 2023

Comparative animal models generate fundamental scientific knowledge of immune responses. However, these studies typically are conducted in mammals because their biochemical and physiological similarity to humans. Presently, there has been an interest using teleost fish study intestinal immunology, particularly mucosa response. Instead targeting the pathogen itself, a preferred approach for managing health is through nutrient supplementation, as it noninvasive less labor intensive than vaccine administrations while still modulating properties. Amino acids (AAs) regulate metabolic processes, oxidant-antioxidant balance, requirements improve Thus, nutritionists can develop sustainable aquafeeds AA supplementation promote specific responses, including system. We propose use dietary with functional AAs response by discussing immunology within intestine explore how oxidative burst used defense mechanism. evaluate components responses that balance potential selection metabolites mucosal capacity gut integrity. effective modulators immunity balance. To incorporate nutrition immunoregulatory means teleost, we must obtain more tools genomic, proteomic, nutrition, macrobiotic metabonomic analyses, so future provide holistic understanding system fish.

Language: Английский

Citations

8