Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 28, 2024
Butylated
Hydroxytoluene
(BHT)
is
found
to
exert
cellular
toxicity
through
induction
of
oxidative
stress
although
being
used
as
antioxidant
in
many
food
products.
This
study
investigates
the
protective
effects
two
herbal
compounds
Boeravinone
B
(BB)
and
Chebulinic
acid
(CA)
combination
(B4C3
i.e.
BB
4
µg/mL
CA
3
µg/mL).
Key
findings
revealed
that
BHT
exerted
ROS
(234.47
a.u.)
RNS
(0.042
µM/mL),
but
B4C3
has
significantly
reduced
it
(115.46
a.u.
0.018
µM/mL
respecctively).
exposure
raised
activities
enzymes
such
SOD
(70.9%),
CAT
(7.08
units/mL),
GPX
(1.21
levels
protein
carbonyls
(3.52
units/mg)
lipid
peroxides
(418.34%).
Whereas
treatment
with
decreased
(29.92%),
(3.12
(0.36
(0.91
units/mg
protein)
(106.67%)
during
exposure.
It
was
20.56%
cells
were
apoptotic
while
73.83%
autophagic
treatment.
However,
proposed
phytotherapy
rescued
from
death
supported
cell
growth
which
confirmed
by
RT-PCR
analysis.
Collectively,
offered
a
significant
protection
against
BHT-induced
damage,
suggesting
its
potential
therapeutic
agents
for
stress-related
hepatotoxicity.
Aquaculture Reports,
Journal Year:
2024,
Volume and Issue:
35, P. 101961 - 101961
Published: Feb. 9, 2024
The
experiment
focused
on
the
study
aimed
to
investigate
effects
of
adding
alanyl-glutamine
(Ala-Gln)
feed
growth,
serum
biochemical
parameters,
and
mRNA
expression
levels
stress-related
genes
in
largemouth
bass
(Micropterus
salmoides)
under
dual
stress
conditions
density
flow
rate.
fish
were
divided
into
three
groups:
control
group,
group
with
0.9
%
Ala-Gln
addition
underwent
a
60
day
aquaculture
experiment.
data
showed
that
final
weight,
average
weight
gain
rate,
specific
growth
rate
efficiency
significantly
decreased
(P
<
0.05).
At
same
time,
glucose
malondialdehyde
(MAD),
activities
aspartate
aminotransferase
(AST)
alanine
transaminase
(ALT)
increased
stress,
while
total
antioxidant
capacity
lysozyme
activity
Moreover,
hormone
(GH),
insulin-like
factor-Ⅰ(IGF-I),
nuclear
factor
kappa-B
(NF-κB),
interleukin-1β
(IL-1β),
tumor
necrosis
factor-α
(TNF-α),
interleukin-8
(IL-8),
transcription
E2
related
2
(Nrf2),
catalase
(CAT),
superoxide
dismutase
(SOD),
Caspase
3,
8
B-cell
lymphoma-2
(Bcl2)
all
significantly,
HSP
70,
90,
interleukin-10
(IL-10),
I-kappa-B-alpha
(IkBα),
kelch-1ike
ECH-
associated
protein
1
(Keap1)
bcl2-associated
X
(Bax)
However,
performance,
indexes
most
correction
trend
after
addition,
but
still
did
not
reach
level
group.
These
results
reduced
parameters
adverse
genes,
exogenous
Ala-Glu
could
somewhat
ameliorate
negative
bass.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116828 - 116828
Published: Aug. 1, 2024
The
neonicotinoid
pesticide
acetamiprid
has
been
widely
used
in
agricultural
pest
control
and
was
frequently
detected
the
water
environment.
There
have
some
studies
of
toxic
effects
on
fish,
but
aquatic
lower
vertebrates
are
still
very
limited.
As
a
primitive
jawless
vertebrate,
Lethenteron
reissneri
special
position
evolution
is
now
listed
as
national
second
level
protected
animal
China.
present
study
aimed
to
investigate
effect
liver
L.
larvae.
A
conjoint
analysis
transcriptomics
metabolomics
performed
determine
responses
larvae
at
different
concentrations
(L
for
low
concentration
25
mg/L
H
high
100
mg/L).
Even
can
cause
significant
damage
short
period.
In
omics
analyses,
2141
differentially
expressed
genes
(DEGs)
183
abundant
metabolites
(DAMs)
were
identified
H/Control
group,
229
DEGs
144
DAMs
L/C
group.
Correlation
analyses
revealed
affected
metabolic
pathways
such
glycerophospholipid
metabolism
arachidonic
acid
metabolism.
This
not
only
enriches
basis
understanding
exposure
provides
more
information
breeding
conservation
reissneri,
also
further
causes
attention
toxicity
risk
from
vertebrate
species.
