Impacts of dietary Ajwain (Trachyspermum ammi L.) on growth, Antioxidative capacity, immune responses, and intestinal histology of grey mullet (Liza ramada)

Aquaculture, Journal Year: 2024, Volume and Issue: unknown, P. 741706 - 741706

Published: Oct. 1, 2024

Language: Английский

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Administration of Cetobacterium somerae ceto isolated from the intestine of yellow catfish (Pelteobagrus fulvidraco) as potential probiotics against chronic ammonia stress

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742352 - 742352

Published: Feb. 1, 2025

Language: Английский

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Autophagy, apoptosis, and inflammation response of Sebastiscus marmoratus to different concentrations of hydroxychloroquine

Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11

Published: July 1, 2024

Hydroxychloroquine (HCQ) is an important public health therapeutic agent widely used in the prevention and treatment of malaria autoimmune diseases, with some antiviral effects, as well a common autophagy inhibitor. Its autophagy-inhibiting effect attracts great research interest mammals but still little studied fish. We even have no idea about effects HCQ on different tissues fish what concentrations should be for safety studies. This study investigated concentration treatments survival, tissue structure, expressions genes related to autophagy, apoptosis, inflammation gill, spleen, testis, ovary Sebastiscus marmoratus . The results showed that higher (77.40 154.80 mg/mL) led mass mortality within hour. half-lethal ( LC 50 , 24 h) S. was approximately 48.95 mg/mL. When exposed 30.96 mg/mL hours, blocked revealed by electron microscopy from spleen testis autophagy-related LC3 / Cx43 ), apoptosis-related Cas3 p53 inflammation-related TNF-α IL8 ) exhibited tissue-specific dose-dependent responses. gonads preferential expression all these were found sensitive regular after treatment. For example, at mg/mL, demonstrated regularity suggests it ideal candidate studying role or autophagy. systematically response provided optional assay key tissues, serving reference future studies Furthermore, potential crosstalk between inflammatory pathways initially identified this could helpful regulation marine

Language: Английский

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Activation autophagy enhances ammonia detoxification by boosting urea and glutamine synthesis in yellow catfish (Pelteobagrus fulvidraco)

Aquaculture, Journal Year: 2024, Volume and Issue: 594, P. 741453 - 741453

Published: Aug. 3, 2024

Language: Английский

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Ellagic acid can mitigate chronic ammonia stress-induced adverse effects through the augmentation of liver autophagy in yellow catfish (Pelteobagrus fulvidraco)

Aquaculture, Journal Year: 2024, Volume and Issue: 592, P. 741171 - 741171

Published: June 5, 2024

Language: Английский

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Potential role of host autophagy in Clonorchis sinensis infection

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

An in vivo mouse model of Clonorchis sinensis (C. sinensis) infection with or without the administration autophagy inhibitor chloroquine (CQ) stimulation was established to assess possible involvement autophagic response during C. infection. Abnormal liver function observed at four, six, eight weeks post-infection, as indicated by elevated levels ALT/GPT, AST/GOT, TBIL, α-SMA infected group. Our findings activated autophagy, shown a decreased LC3II/I ratio and accumulated P62 expression mice. Interestingly, CQ exhibited dual opposing effects In early stage infection, engagement appeared mitigates symptoms reducing inflammation fibrotic responses. However, later might contribute parasite survival evading targeting, thereby exacerbating hepatic impairment worsening fibrosis. Autophagy suppressed throughout These observations attested that triggered highlighted complex role for CQ, both protective detrimental effects, progression

Language: Английский

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Potential role of host autophagy in Clonorchis sinensis infection

Parasitology Research, Journal Year: 2024, Volume and Issue: 123(10)

Published: Oct. 1, 2024

Language: Английский

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A comprehensive analysis of metabolomics and transcriptomics revealed the mTOR-autophagy pathway is involved in ammonia metabolism of yellow catfish Pelteobagrus fulvidraco

Aquaculture, Journal Year: 2024, Volume and Issue: 596, P. 741849 - 741849

Published: Nov. 3, 2024

Language: Английский

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