Ferulic acid alleviates cardiac injury by inhibiting avermectin-induced oxidative stress, inflammation and apoptosis DOI
Qiao Wang, Shasha Zhang,

Jiahao Ding

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 287, P. 110058 - 110058

Published: Oct. 21, 2024

Language: Английский

Tea Polyphenol Protects the Immune Barrier and Inhibits TLR2/NF-κB/MLCK Signal Activation to Prevent Inflammatory Injury in the Intestines of Common Carp (Cyprinus carpio L.) DOI Creative Commons

Man Qian,

Jie Yang, Xue Yao

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 387 - 387

Published: Jan. 30, 2025

Tea polyphenol (TP) is a kind of natural macromolecular compound present in tea extract with rich biological potential. The purpose this study was to explore the protective effect TP on intestinal immune barrier and related mechanisms alleviating injury. Models common carp (Cyprinus carpio L.) primary epithelial cells treated lipopolysaccharide (LPS) were established. qPCR ELISA results showed that increased levels lysozyme (LZ), alkaline phosphatase (ALP), complement component 3 (C3), 4 (C4), immunoglobulin T (IgT), D (IgD), M (IgM) activate ability. Molecular docking indicated had strong interaction TLR2. Meanwhile, alleviated LPS-induced inflammatory damage as evidenced by reducing mRNA TNF-α, IL-6, IL-1β, TLR2, MyD88, P65, IκBα, which consistent those Western blotting results. Moreover, revealed promoted tight junction-related proteins (claudins, occludin, ZOs) inhibited phosphorylation MLC, opposite trend after LPS treatment. In summary, improved ability activation TLR2/NF-κB/MLCK pathway attenuate injury intestines carp.

Language: Английский

Citations

0
Palliative potential of velutin against abamectin induced cardiac toxicity via regulating JAK1/STAT3, NF-κB, Nrf-2/Keap-1 signaling pathways: An insight from molecular docking DOI

Mahmoud El Safadi,

Qurat‐ul‐Ain Ahmad,

Muhammad Majeebullah

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 205, P. 106117 - 106117

Published: Sept. 4, 2024

Language: Английский

Citations

2
Phosphate perils in marine aquaculture: Systematic toxicity assessment in turbot juveniles in cultivation DOI
Lele Wu, Xin Li, Jiale Zhou

et al.

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
Ferulic acid alleviates cardiac injury by inhibiting avermectin-induced oxidative stress, inflammation and apoptosis DOI
Qiao Wang, Shasha Zhang,

Jiahao Ding

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 287, P. 110058 - 110058

Published: Oct. 21, 2024

Language: Английский

Citations

0