Published: Jan. 1, 2025
Language: Английский
Journal of Fish Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
ABSTRACT MicroRNA‐33 (miR‐33) plays a critical role in the regulation of autophagy and inflammatory responses. In this study, C. idella kidney (CIK) cells were transfected with miR‐33 mimic or inhibitor Atg5 was overexpressed silenced to elucidate regulatory mechanism miR‐33. Our findings revealed that significantly decreased expression LC3B (a marker activation), level autophagy‐related genes ( Beclin‐1 , LC3‐1 ) also downregulated p < 0.05). Additionally, promoted secretion proinflammatory factors, including TNF‐α, IL‐6, IL‐12 IL‐1β contrast, enhanced protein increased relative The factors (TNF‐α, IL‐6 IL‐12) reduced These results suggested inhibition could induce initiation attenuate response CIK cells. Furthermore, we identified as direct target gene Overexpression upregulated levels Atg4C along reduction IL‐1β). Besides, activities superoxide dismutase (SOD) catalase (CAT) Conversely, interference caused significant downregulation Atg12 resulting activity acid phosphatase (ACP) SOD Taken together, these promote inflammation through targeting . This study not only enhances understanding by which regulates fish but provides theoretical foundation novel insights improve disease management aquaculture industry.
Language: Английский
Citations
0
Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742428 - 742428
Published: March 1, 2025
Language: Английский
Citations
0
One Health Advances, Journal Year: 2025, Volume and Issue: 3(1)
Published: March 31, 2025
Abstract Aquaculture has rapidly developed into one of the most fast-expanding food industries, providing an essential source protein for humanity worldwide. The rapid growth aquaculture industry is closely associated with crucial role antimicrobials in prevention and treatment animal diseases. Nevertheless, irrational utilization gives rise to emergence pathogen resistance, which poses a potential threat human health environmental sustainability. This issue garnered considerable attention from international organizations escalated global public crisis that requires urgent intervention. paper undertakes review sources antimicrobial resistance aquaculture, drawing on data Microbial Browser Identification Genetic Genomic Elements (MicroBIGG-E) related literature. characteristics distribution patterns drug genes pathogenic bacteria diseased aquatic animals food-borne contaminated products were elaborated detail. resistant not solely attributable but rather social activities. Diverse tetracyclines, aminoglycosides, β-lactams, quinolones, sulfonamides, amphenicols coexist foodborne pathogens might contribute multidrug aquaculture. also evaluates risks respect health, safety, ecological balance. Government entities, research institutions, private companies are adopting proactive measures initiating specific strategies alleviate dissemination thereby enhancing as well
Language: Английский
Citations
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Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 831 - 831
Published: April 6, 2025
Bacteriophages, or phages, which are viruses with specifically restricted tropism for bacteria, have regained interest in the last few decades as alternative therapeutic agents against antibiotic-resistant pathogenic bacteria animals and humans worldwide. In this context, bacteriophage therapy has been developed to treat bacterial infections of cultured fish, shellfish, crustaceans. Nowadays, aquaculture is only feasible solution meet continuously growing global demand high-quality seafood. As such, it crucial focus on controlling spread they a significant economic impact systems. Overall, documented research supports application aquaculture, but also underlies need additional studies, still mostly scientific stage. This review aims highlight critically examine recent advancements bacteriophages most common infectious diseases both freshwater saltwater species, providing topical perspectives innovative advances.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0