Role of TLRs as signaling cascades to combat infectious diseases: a review DOI Creative Commons
Md. Salauddin, Debaraj Bhattacharyya, Indranil Samanta

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: March 19, 2025

Investigating innate immunity and its signaling transduction is essential to understand inflammation host defence mechanisms. Toll-like receptors (TLRs), an evolutionarily ancient group of pattern recognition receptors, are crucial for detecting microbial components initiating immune responses. This review summarizes the mechanisms outcomes TLR-mediated signaling, focusing on motifs shared with other immunological pathways, which enhances our understanding system. TLRs recognize molecular patterns in invaders, activate promote antigen-specific adaptive immunity, each them triggers unique downstream patterns. Recent advances have highlighted importance supramolecular organizing centers (SMOCs) TLR ensuring precise cellular responses pathogen detection. Furthermore, this illuminates how pathways coordinate metabolism gene regulation, contributing providing novel insights next-generation therapeutic strategies. Ongoing studies hold promise treatments against infectious diseases, autoimmune conditions, cancers.

Language: Английский

Molecular Response and Metabolic Reprogramming of the Spleen Coping with Cold Stress in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis) DOI Creative Commons
Liqin Ji, Qing Shi,

Yisen Shangguan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 14, 2025

The Chinese soft-shelled turtle (Pelodiscus sinensis), as a type of warm-water reptile, could be induced to massive death by sharp temperature decline. Hence, the mechanism spleen tissue responding cold stress in P. sinensis was investigated. present results showed that superoxide dismutase (SOD) activity declined from 4 16 days post-cold-stress (dps), while catalase (CAT) and glutathione peroxidase (GSH-Px) activities increased, 8 dps 14 °C (T14) 7 (T7) groups. transcriptome T7 group control (CG) at obtained 2625 differentially expressed genes (DEGs), including 1462 upregulated 1663 downregulated genes. DEGs were enriched mainly pathways "intestinal immune network for IgA production" (Pigr, Il15ra, Tnfrsf17, Aicda, Cd28), "toll-like receptor signaling pathway" (Mapk10, Tlr2, Tlr5, Tlr7, Tlr8), "cytokine-cytokine interaction" (Cx3cl1, Cx3cr1, Cxcl14, Cxcr3, Cxcr4). metabolomic data esculentic acid, tyrosol, diosgenin, heptadecanoic 7-ketodeoxycholic acid obviously baccatin III, taurohyocholate, parthenolide, enterolactone, tricin decreased, CG vs. comparison. Integrated analysis two omics revealed "glycine, serine threonine metabolism", "FoxO pathway", "neuroactive ligand-receptor main stress. Overall, this work found low remarkably influenced antioxidant enzyme activities, gene expression pattern, metabolite profile spleen, indicating immunity might weakened sinensis.

Language: Английский

Citations

0
Expression of antioxidant and stress-related genes in olive flounder, Paralichthys olivaceus exposed to high temperatures after pre-heating DOI
Da-In Lee,

Ju-Hyeong Lee,

Kyung‐Hee Kim

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 291, P. 110147 - 110147

Published: Feb. 16, 2025

Language: Английский

Citations

0
Role of TLRs as signaling cascades to combat infectious diseases: a review DOI Creative Commons
Md. Salauddin, Debaraj Bhattacharyya, Indranil Samanta

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: March 19, 2025

Investigating innate immunity and its signaling transduction is essential to understand inflammation host defence mechanisms. Toll-like receptors (TLRs), an evolutionarily ancient group of pattern recognition receptors, are crucial for detecting microbial components initiating immune responses. This review summarizes the mechanisms outcomes TLR-mediated signaling, focusing on motifs shared with other immunological pathways, which enhances our understanding system. TLRs recognize molecular patterns in invaders, activate promote antigen-specific adaptive immunity, each them triggers unique downstream patterns. Recent advances have highlighted importance supramolecular organizing centers (SMOCs) TLR ensuring precise cellular responses pathogen detection. Furthermore, this illuminates how pathways coordinate metabolism gene regulation, contributing providing novel insights next-generation therapeutic strategies. Ongoing studies hold promise treatments against infectious diseases, autoimmune conditions, cancers.

Language: Английский

Citations

0