Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 928 - 928
Published: Feb. 17, 2025
The European Union, producing over 2.5 billion tons of waste annually, has prompted the Parliament to implement legal measures and encourage shift towards a circular economy. Millions biowaste from olive plant leaves are generated resulting in environmental economic challenges. To address this, was valorized, extraction valuable components, triterpenes polyphenols, which hold potential pharmaceutical, food, or cosmetic applications. Our research involved formulation triterpene extract (TTP70, 70% triterpenes) as solid dispersion using Poloxamer-188 (P188) Poloxamer-407 (P407). dispersions were prepared kneading method various extract-to-polymer weight ratios, including 1:1, 1:2, 1:5. influence hydrophilic carriers on solubility, dissolution profile, vitro passive permeability TTP70 evaluated. Both all considered ratios significantly improved solubility hydrophobic triterpenes. PAMPA experiments demonstrated efficacy improving permeation Subsequently, physically mixed with polyphenol-enriched (OPA40, 49% polyphenols) also obtained leaves, they used fill hard gelatin capsules produce an oral dosage form. composite formulations both classes constituents.
Language: Английский