Viruses,
Journal Year:
2024,
Volume and Issue:
16(4), P. 647 - 647
Published: April 22, 2024
Consistent
with
the
biochemistry
of
coronaviruses
as
well
established
over
decades,
SARS-CoV-2
makes
its
initial
attachment
to
host
cells
through
binding
spike
protein
(SP)
sialylated
glycans
(containing
monosaccharide
sialic
acid)
on
cell
surface.
The
virus
can
then
slide
and
enter
via
ACE2.
SP
attaches
particularly
tightly
trillions
red
blood
(RBCs),
platelets
endothelial
in
human
body,
each
very
densely
coated
acid
surface
molecules
but
having
no
ACE2
or
minimal
These
interlaced
attachments
trigger
aggregation,
microvascular
occlusion
vascular
damage
that
underlie
hypoxia,
clotting
related
morbidities
severe
COVID-19.
Notably,
two
betacoronaviruses
express
a
acid-cleaving
enzyme
are
benign,
while
other
three—SARS,
MERS—are
virulent.
RBC
aggregation
experimentally
induced
several
animal
species
using
an
injected
polysaccharide
caused
most
same
This
glycan
is
key
disentangling
controversies
have
arisen
efficacy
certain
generic
COVID-19
treatment
agents
safety
SP-based
vaccines.
More
broadly,
disregard
for
active
physiological
role
RBCs
yields
unreliable
erroneous
reporting
pharmacokinetic
parameters
routinely
obtained
drugs
bioactive
detection
plasma,
whole-blood
levels
being
up
30-fold
higher.
Appreciation
elucidate
underpinnings
health
conditions,
including
cardiovascular
disease,
therapeutic
opportunities
address
them.
Sustainability Science,
Journal Year:
2023,
Volume and Issue:
18(2), P. 557 - 568
Published: March 1, 2023
Abstract
This
editorial
lays
out
the
core
themes
of
special
feature
and
provides
an
overview
contributions.
It
introduces
main
argument,
namely
that
promises
far-reaching
change
made
by
recent
bioeconomy
policies
are
in
fact
strategically
directed
at
avoiding
transformative
to
existing
societal
arrangements.
Bioeconomy
discourse
showcases
technological
solutions
purported
solve
sustainability
‘problems’
while
sustaining
economic
growth,
but
avoids
issues
scalability,
integration
or
negative
consequences.
Thus,
policies,
particularly
latest
versions
predominantly
European
‘bio-resource’
variety
have
rhetorically
integrated
a
lot
previous
sustainability-minded
criticism,
serve
ward
off
delay
challenges
unsustainable
status
quo,
effect
prolongating
escalatory
imperatives
capitalist
modernity
root
current
crises.
The
editorial’s
second
part
highlights
contributions
13
featured
articles,
based
on
theoretical
considerations
as
well
policy
analyses
empirical
case
studies
from
range
countries,
make
this
argument.
Royal Society Open Science,
Journal Year:
2023,
Volume and Issue:
10(7)
Published: July 1, 2023
Replacing
traditional
journals
with
a
more
modern
solution
is
not
new
idea.
Here,
we
propose
ways
to
overcome
the
social
dilemma
underlying
decades
of
inaction.
Any
needs
only
resolve
current
problems
but
also
be
capable
preventing
takeover
by
corporations:
it
replace
decentralized,
resilient,
evolvable
network
that
interconnected
open
standards
and
open-source
norms
under
governance
scholarly
community.
It
monopolies
connected
genuine,
functioning
well-regulated
market.
In
this
market,
substitutable
service
providers
compete
innovate
according
conditions
community,
avoiding
sustained
vendor
lock-in.
Therefore,
body
form
community
allow
development
infrastructures
servicing
entire
research
workflow.
We
redirection
money
from
legacy
publishers
funding
bodies
broadening
their
minimal
infrastructure
requirements
at
recipient
institutions
include
components
replacing
complementing
journal
functionalities.
Such
updated
eligibility
criteria
agencies
would
help
realign
financial
incentives
for
public
interest.
Agronomy for Sustainable Development,
Journal Year:
2024,
Volume and Issue:
44(2)
Published: April 1, 2024
Abstract
Plant
production
systems
worldwide
are
struggling
to
meet
the
diverse
and
increasing
needs
of
humankind
while
also
facing
challenges
such
as
climate
change
biodiversity
loss.
This,
combined
with
desirable
transition
from
use
conventional
pesticides
more
sustainable
plant
protection
solutions,
has
led
an
urgent,
increasing,
need
for
low-risk
products
(PPPs)
be
developed,
applied,
integrated
into
management
practices
across
all
types
systems.
Despite
a
high
demand
end
users
consumers
together
joint
political
goals
at
EU
level
replace
pesticides,
number
PPPs
on
European
market
remains
low,
in
comparison
synthetic
agrochemicals.
In
this
review,
we
summarize
knowledge
about
policy,
technical,
administrative
issues
hampering
process
bringing
new
market.
We
present
overview
using
that
currently
available
within
agricultural,
horticultural,
forestry
sectors.
describe
variation
modes
action
limitations
associated
different
application
techniques
give
concrete
examples
problems
solutions
Swedish
sectors,
contrast
global
perspectives
demonstrated
by
African
agriculture.
Finally,
conclude
trans-sectoral,
multi-actor
approaches
required
provide
suggestions
how
address
remaining
gaps
related
efficiency,
application,
economics
PPP
Integrated
Pest
Management
(IPM)
improve
future
food
security
Europe.
Canadian Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
40(10), P. 1828 - 1840
Published: June 15, 2024
The
potential
of
artificial
intelligence
(AI)
in
medicine
lies
its
ability
to
enhance
clinicians'
capacity
analyse
medical
images,
thereby
improving
diagnostic
precision
and
accuracy
thus
enhancing
current
tests.
However,
the
integration
AI
within
health
care
is
fraught
with
difficulties.
Heterogeneity
among
system
applications,
reliance
on
proprietary
closed-source
software,
rising
cybersecurity
threats
pose
significant
challenges.
Moreover,
before
their
deployment
clinical
settings,
models
must
demonstrate
effectiveness
across
a
wide
range
scenarios
be
validated
by
prospective
studies,
but
doing
so
requires
testing
an
environment
mirroring
workflow,
which
difficult
achieve
without
dedicated
software.
Finally,
use
techniques
raises
legal
ethical
issues,
such
as
protection
patient
privacy,
prevention
bias,
monitoring
device's
safety
for
regulatory
compliance.
This
review
describes
challenges
provides
guidelines
how
move
forward.
We
describe
open-source
solution
that
we
developed
integrates
into
Picture
Archives
Communication
System
(PACS),
called
PACS-AI.
approach
aims
increase
evaluation
facilitating
validation
existing
imaging
databases.
PACS-AI
may
overcome
many
barriers
offer
pathway
toward
responsible,
fair,
effective
care.
In
addition,
propose
list
criteria
researchers
should
adopt
when
publishing
model
standardisation
reproducibility.
Environmental Science & Policy,
Journal Year:
2023,
Volume and Issue:
142, P. 99 - 111
Published: Feb. 16, 2023
Current
approaches
and
cultures
for
the
economic
evaluations
of
environmental
health
policies
may
suffer
from
excessive
reliance
on
a
standard
neoclassic
toolbox
that
neglects
alternative
perspectives.
This
prematurely
limit
spectrum
available
policy
options.
Here
we
show
how
inclusion
neglected
currents
thought
such
as
non-Ricardian
economics,
bioeconomics
set
qualitative-quantitative
methods
post-normal
science
leads
to
richer
perspectives
more
inclusive
uses
quantitative
evidence,
opens
analysis
possible
futures.
We
also
present
some
case
studies
in
energy,
water,
climate
domains
highlight
point
practical
context
policy-oriented
audience.
situate
our
recent
calls
EU
social
sciences
humanities
assessment
works.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(23), P. 17039 - 17039
Published: Dec. 1, 2023
Consistent
with
well-established
biochemical
properties
of
coronaviruses,
sialylated
glycan
attachments
between
SARS-CoV-2
spike
protein
(SP)
and
host
cells
are
key
to
the
virus’s
pathology.
SP
attaches
aggregates
red
blood
(RBCs),
as
shown
in
many
pre-clinical
clinical
studies,
causing
pulmonary
extrapulmonary
microthrombi
hypoxia
severe
COVID-19
patients.
heavily
surfaces
platelets
(which,
like
RBCs,
have
no
ACE2)
endothelial
(having
minimal
compound
this
vascular
damage.
Notably,
experimentally
induced
RBC
aggregation
vivo
causes
same
morbidities
for
COVID-19,
including
microvascular
occlusion,
clots,
myocarditis.
Key
risk
factors
morbidity,
older
age,
diabetes
obesity,
all
characterized
by
markedly
increased
propensity
clumping.
For
mammalian
species,
degree
susceptibility
correlates
aggregability
p
=
0.033.
five
human
betacoronaviruses,
two
common
cold
strains
express
an
enzyme
that
releases
attachments,
while
deadly
SARS,
MERS
do
not,
although
viral
loads
infections
similar.
These
insights
also
explain
previously
puzzling
efficacy
certain
generics
against
may
support
development
future
therapeutic
strategies
long
COVID
Royal Society Open Science,
Journal Year:
2023,
Volume and Issue:
10(7)
Published: July 1, 2023
Twitter
is
in
turmoil
and
the
scholarly
community
on
platform
once
again
starting
to
migrate.
As
with
early
internet,
organizations
are
at
forefront
of
developing
implementing
a
decentralized
alternative
Twitter,
Mastodon.
Both
historically
conceptually,
this
not
new
situation
for
community.
Historically,
scholars
were
forced
leave
social
media
FriendFeed
after
it
was
bought
by
Facebook
2006.
Conceptually,
problems
associated
public
discourse
subjected
whims
corporate
owners
unlike
those
journals
owned
monopolistic
corporations:
both
cases
perils
good
private
hands
palpable.
For
short
form
(Twitter/Mastodon)
longer
(journals)
discourse,
solutions
exist,
some
which
already
enjoying
institutional
support.
Here
we
argue
that
organizations,
particular
learned
societies,
now
facing
golden
opportunity
rethink
their
hesitations
towards
such
alternatives
support
migration
from
Mastodon
hosting
instances.
Demonstrating
capable
creating
truly
square
impervious
takeover,
might
renew
confidence
inspire
focus
analogous
remaining
record—encompassing
text,
data
code—to
safeguard
all
publicly
knowledge.
Consistent
with
the
biochemistry
of
coronaviruses
as
well
established
over
decades,
SARS-CoV-2
makes
its
initial
attachment
to
host
cells
through
binding
spike
protein
(SP)
sialylated
glycans
(containing
monosaccharide
sialic
acid)
on
cell
surface.
The
virus
can
then
slide
and
enter
via
ACE2.
SP
attaches
particularly
tightly
trillions
red
blood
(RBCs),
platelets
endothelial
in
human
body,
each
very
densely
coated
acid
surface
molecules
but
having
no
ACE2
or
minimal
These
interlaced
attachments
trigger
aggregation,
microvascular
occlusion
vascular
damage
that
underlie
hypox-ia,
clotting
related
morbidities
severe
COVID-19.
Notably,
two
betacoro-naviruses
express
a
acid-cleaving
enzyme
are
benign,
while
other
three—SARS,
MERS—are
virulent.
RBC
aggregation
experimentally
induced
several
animal
species
using
an
injected
polysaccharide
caused
most
same
This
glycan
is
key
disentangling
controversies
have
arisen
efficacy
certain
generic
COVID-19
treatment
agents
safety
SP-based
vaccines.
More
broadly,
disregard
for
active
physiological
role
RBCs
yields
unreliable
erroneous
report-ing
pharmacokinetic
parameters
routinely
obtained
drugs
bioactive
detection
plasma,
whole-blood
levels
being
up
30-fold
higher.
Appreciation
elucidate
underpinnings
health
conditions,
in-cluding
cardiovascular
disease,
therapeutic
opportunities
address
them.
[This
preprint
addendum
published
paper
title
abstract
above,
it
covers
issues
science
policy
integrity
not
directly
biochemical
focus
paper.
formatting
used
this
was
applied
be
consistent
paper.]
