Hyperbaric Oxygen Therapy in the Treatment of Crohn’s Disease

Healthcare, Journal Year: 2025, Volume and Issue: 13(2), P. 128 - 128

Published: Jan. 11, 2025

Background/Objectives: Our study describes hyperbaric oxygen therapy (HBOT) as an additional in the conservative treatment of Crohn’s disease (CD) and its benefit early postoperative period to prevent surgical complications improve gastrointestinal motility. Methods: This retrospective evaluated HBOT patients hospitalized at Clinical Hospital Center Split for CD between 2015 2020. Patients (N = 61) aged 19 67 with perianal fistulas, abscesses, obstruction, stenosis, or bleeding were included, excluding those ulcerative colitis requiring intensive care. retrospectively divided into conservatively surgically treated groups, was administered over 15–25 days, lasting 60 min 2.2 absolute atmospheres (ATA). We analyzed outcomes HBOT-treated groups compared a cohort from preceding five years who did not receive HBOT. Results: 61 HBOT, including 34 27 patients. significantly reduced activity indices (311.7 ± 59.1 vs. 114 29.8; 203.6 24.1 83.8 15, patients, 352.8 45.7 109 22.8; 270.4 19.7 140.3 10.6 patients) accelerated bowel peristalsis recovery, 94.1% achieving remission. Comparison historical showed faster recovery improved group. Conclusions: is useful postponing avoiding treatment, operated it improves reduces rate complications.

Language: Английский

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Crohn's Colitis Care, a Disease‐Specific Electronic Medical Record, Enhances Data Capture in Pediatric Inflammatory Bowel Disease Care

JGH Open, Journal Year: 2025, Volume and Issue: 9(5)

Published: April 30, 2025

Crohn's Colitis Care, a structured, disease-specific electronic medical record, is proven to promote more complete data capture in adult Inflammatory Bowel Disease care. This study aimed determine whether similar effectiveness was seen pediatrics. Matched patient records from hospital's standard record (pre-Crohn's Care) and those Care were retrospectively reviewed (12 months each). The presence of items per platform compared (21 core, 5 age-specific). Data are presented as percentage recorded (recorded items/total eligible for age). Descriptive statistical analytics used. Paired 114 children, whom 78 (68%) had disease 69 (61%) male. Median age at diagnosis 13.5 years (IQR12.0-15.5), with mean duration 3.6 (±2.4). likely 9 items: general wellbeing, stool urgency frequency, duration, comorbidities, pubertal stage, sexual activity, alcohol drug usage (each p < 0.05). 4 liquid stools, phenotype, indices, vaccinations achieved (75.3% ±11.5 vs. 67.7% ± 8.9; 0.001). Item completion rate both platforms inversely correlated (p Consistent findings care, disease-data pediatrics platform. Given that not all better the structured platform, work understand address barriers needed optimize care research.

Language: Английский

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Nutritional Deficiencies and Reduced Bone Mineralization in Ulcerative Colitis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3202 - 3202

Published: May 6, 2025

Background: Inadequate dietary intake of vitamin D, K, and calcium, as well sub-optimal sunlight exposure, can lead to bone loss in the general population, more so patients with ulcerative colitis, who are burdened by additional predisposing factors for osteoporosis, such chronic inflammation cortisone use. However, micronutrient deficiencies, if present, easily corrected nutritional intervention. While relation between calcium D metabolism is known, fewer data available both healthy individuals patients. The aim this review provide an overview recent reports focusing on deficits relevant development osteoporosis/osteopenia affected colitis. Methods: A systematic electronic search English literature up January 2025 was performed using Medline Cochrane Library. Results: Despite being central mineralization, colitis relatively scarce, deriving mostly from mixed inflammatory bowel disease cohorts. Although lower than controls, approaches recommended daily allowance, which establishes necessary nutrients. Conversely, K deficiencies highly prevalent widely shared opinion that milk lactose-containing foods, vegetables, worsen diarrhea a prime determinant inadequate intake. Conclusions: Increased awareness importance nutrition common occurrence represents first step intervention strategies counteract increased risk osteoporosis

Language: Английский

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Too Many Couch Potatoes Among Middle-Aged Inflammatory Bowel Disease Patients: Findings from the “BE-FIT-IBD-2” Study

Gastroenterology Insights, Journal Year: 2024, Volume and Issue: 15(4), P. 963 - 975

Published: Nov. 4, 2024

Background: Regular physical activity (PA) is desirable, regardless of age, even in patients with chronic conditions such as inflammatory bowel disease (IBD). Aims: This study aims to assess PA levels and related barriers/facilitators IBD patients, stratifying them into age groups (with a threshold 50 years). Methods: The International Questionnaire (IPAQ) assessed regarding resting metabolic rate (Met) minutes per week (min/wk). Patient-reported outcomes 2 (PRO-2) evaluated activity. Results: Among the 237 enrolled rates were found differ significantly terms being sufficiently active (55% vs. 39.8%), inactive (39.6% 59.1%), engaging health-enhancing (5.4% 1.1%) between under at least years old, respectively (p < 0.001). Overall, followed this trend, higher younger [892 (446.5–1439) 545.25 (257–1210.47) Met min/wk, p = 0.007]. Individuals aged tend have lower regression analysis (OR: 3.302, 0.018). Patients perceived more barrier 0.04). Bowel urgency significant barrier, especially older 0.022). Conclusions: Age an unmodifiable factor impacting influencing levels. Strategies recover exercise should be encouraged.

Language: Английский

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Morning Salivary Cortisol Has a Positive Correlation with GAD-7 Scores in Patients with Ulcerative Colitis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6707 - 6707

Published: Nov. 8, 2024

Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Earlier onset IBD symptoms has been linked to a higher prevalence depression anxiety. Evidence supports that cortisol abnormalities correlate with development severity autoimmune diseases. The primary aim this study was investigate correlation morning salivary levels self-reported mood (depression anxiety) quality life in patients IBD.

Language: Английский

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Nutritional Consequences of Celiac Disease and Gluten-Free Diet

Gastroenterology Insights, Journal Year: 2024, Volume and Issue: 15(4), P. 878 - 894

Published: Sept. 27, 2024

Celiac disease is an immune-mediated condition triggered by gluten ingestion in genetically predisposed individuals. The global prevalence of celiac significant, affecting approximately 1.4% women and 0.7% men, with incidence rates 17.4 7.8 per 100,000 person-years, respectively. clinical presentation may range from overt diarrhea malabsorption to more subtle features such as nutritional deficiencies extraintestinal manifestations. It the most common cause Western countries. A life-long gluten-free diet only available treatment for disease. Moreover, a often adopted individuals without disease, either address non-celiac sensitivity or other reasons. This review aims explore current understandings consequences untreated impact itself. Physicians dietitians specializing should focus on providing well-rounded scheme caused prevent instauration new imbalances.

Language: Английский

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Novel approach to assess sarcopenia in children with inflammatory bowel disease

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 19, 2024

Introduction Sarcopenia is associated with poor clinical outcomes in chronic diseases. Our study aimed to characterize body composition (BC) parameters patients inflammatory bowel disease (IBD) and compare skeletal muscle mass (SMM) the healthy pediatric population. Methods BC of controls (HC) IBD were measured via multifrequency bioelectrical impedance (InBody 720 device) a cross-sectional manner. The effect sex, age, height, weight, index (BMI) on parameters, special attention SMM, was assessed. Reference tables from SMM generated using maximum-likelihood curve-fitting technique for calculating Z scores. Results size, sex. lower ( n = 57, aged 6.71 ± 8.7 years) compared unadjusted HC 307, 9.9–19.3 years; 143 males; SMM: 22.34 8.38 vs. 24.4 6.3 kg; p 0.03). showed moderately strong correlation BMI R 0.65, 0.9, 0.87, 0.66; &lt; 0.05 each) HC. In multivariate stepwise, ridge regression analysis, remained significant predictors (age β 0.47, −0.31, 0.38, respectively; 0.05). sex-, age-, BMI-adjusted did not differ IBD. Therefore, score–based references plotted normalizing score calculated found be similar that Conclusions supposed an easy-to-measure objective marker sarcopenia children Adjustment might needed avoid overestimation this patient

Language: Английский

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Characterization of Inflammatory Bowel Disease in the Elderly According to Age of Onset

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7581 - 7581

Published: Dec. 13, 2024

Background/Objectives: Elderly populations are under-represented in inflammatory bowel disease (IBD) clinical trials, with limited data on phenotype, treatment patterns, outcomes, and comorbidities. The main objective of this study was to evaluate, an elderly cohort IBD, demographic characteristics, comorbidity, polypharmacy, patterns according the development IBD at or before old age. Secondarily, same analysis performed based type IBD: ulcerative colitis (UC) Crohn’s (CD). Materials Methods: Observational, single-center, retrospective including patients diagnosed aged 65 years older seen office Regional University Hospital Malaga between September November 2022. Data were recorded demographic, disease-related, treatment-related variables, comorbidities, polypharmacy. A descriptive analytical undertaken age onset IBD. Results: Of included, 50.8% male, 55.1% had CD, 44.9% UC. 69.5% ≥65 30.5%. who debuted <65 presented longer duration (19.67 ± 9.82 years) required more IBD-related surgeries (37.8%); (77.69 6.26 years), no differences other variables. According UC (74.55 6.9 used aminosalicylates (77.4%), higher rates polypharmacy (90.6%). CD activity (moderate/severe 72.3%), biologic drugs (58.5%), (44.6%). Conclusions: develop after overall very similar baseline disease-related characteristics. have require surgeries. aminosalicylate use.

Language: Английский

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Physical activity pattern and its influencing factors among patients with inflammatory bowel disease in East China

BMJ Open, Journal Year: 2024, Volume and Issue: 14(12), P. e088445 - e088445

Published: Dec. 1, 2024

Objective To investigate the current level of physical activity (PA) and its influencing factors among patients with inflammatory bowel disease (IBD) in East China. Design Cross-sectional study. Setting Questionnaire survey recruiting from six tertiary referral hospitals China between October December 2023. Participants Patients Crohn’s (CD) or ulcerative colitis (UC) aged 18–65 years without conditions limiting PA engagement. Primary secondary outcome measures outcomes comprised total PA, levels sedentary time over 1 week. Demographic clinical characteristics, disease-related non-disease-related barriers to expectation score were also assessed. Results Of 391 eligible respondents, including 271 CD (69.3%) 237 males (60.6%), median IBD was 594 (0–1695) metabolic equivalent task (MET)-min/week, 53 (13.6%) high, 140 (35.8%) moderate 198 (50.6%) low level. The 2325 (1500~3120) min/week patients, significantly more than UC (p<0.01). A 180 (46.0%) had reduced after diagnosis, 134 (49.4%) 46 (38.3%) (CD vs UC, p<0.05). Multifactorial logistic regression analysis showed that gender (OR=1.704, 95% CI 1.132 2.565, p=0.011) (OR=1.176, 1.090 1.270, p<0.01) independent IBD. Conclusion In China, proportion moderate- high-level considerably low. Compared longer postdiagnostic reduction. Gender scores on patients. These results pointed potential patient populations for future-focused interventions.

Language: Английский

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Oral Spore-Based Probiotic Supplementation Alters Post-Prandial Expression of mRNA Associated with Gastrointestinal Health

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2386 - 2386

Published: Oct. 18, 2024

Background/Objectives: Unregulated post-prandial dietary endotoxemia may accumulate over time and underlie the development of chronic disease (e.g., leaky gut, inflammatory bowel disease, etc.), for which oral probiotic supplementation be a prophylactic. The purpose this study was to determine if 45 d spore-based altered gastrointestinal-associated mRNA expression following high-fat meal. Methods: A subset apparently healthy individuals from larger who had at baseline completed with either placebo (rice flour; n = 10) or (Megasporebiotic™; Novonesis, Kongens Lyngby, Denmark; Bacillus indicus (HU36™), subtilis (HU58™), coagulans (SC208™), licheniformis (SL-307), clausii (SC109™); 10). Venous blood collected in Paxgene RNA tubes prior (PRE), 3 h, 5 h after consumption meal (85% daily fat RDA 65% calorie needs). Total analyzed 579 mRNAs interest (Nanostring nCounter Sprint; Seattle, WA, USA). After normalization housekeeping controls calculation differential relative PRE controlled FDR, 15 were determined significantly changed and/or group but not group. Results: Significant expressions associated gastrointestinal tract barrier function (four mRNAs: BATF3, CCR6, CXCR6, PDCD2), immunity CLEC5A, IL7, CARD9, FCER1G), future IBD risk (seven PD-L1, CSF1R, FAS, BID, FADD, GATA3, KIR3DL). Conclusions: Collectively, present findings support notion that immune response eating is enhanced supplementation.

Language: Английский

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