Depression in Diarrhea-Predominant IBS Patients: Exploring the Link Between Gut Barrier Dysfunction and Erythrocyte Polyunsaturated Fatty Acid Levels DOI Open Access
Michele Linsalata, Laura Prospero, Antonia Ignazzi

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2483 - 2483

Published: April 5, 2025

Background: Patients with irritable bowel syndrome (IBS) often experience comorbid psychological conditions, notably depression and anxiety. Evidence suggests that these conditions are linked to gut barrier dysfunction, dysbiosis, chronic inflammation. All factors central IBS pathophysiology mood disturbances. Polyunsaturated fatty acids (PUFAs) play crucial roles in modulating inflammation depression. This study examined the associations among intestinal permeability, PUFA profiles, low-grade inflammation, severity patients diarrhea (IBS-D). Methods: Forty-three IBS-D (7 men, 36 women; 44.56 ± 1.52 years) were categorized into depressed (IBS-D(d+)) non-depressed (IBS-D(d-)) groups according scores on subscale of Symptom Checklist-90-Revised (SCL-90-R). Biomarkers small permeability (s-IP) assessed urine blood, alongside erythrocyte membrane composition, indices. Results: (d+) exhibited elevated s-IP altered metabolism compared their (d-) counterparts. Additionally, first group, omega-3 concentrations inversely correlated biomarkers, while omega-6/omega-3 ratio showed a positive correlation. Moreover, is significantly associated markers levels. Lastly, higher levels dysbiosis pro-inflammatory cytokines than patients. Conclusions: These findings highlight interplay between integrity depression, suggesting profiles could represent novel therapeutic targets for managing this population. was registered ClinicalTrials.gov (NCT03423069), date registration 30 January 2018.

Language: Английский

Depression in Diarrhea-Predominant IBS Patients: Exploring the Link Between Gut Barrier Dysfunction and Erythrocyte Polyunsaturated Fatty Acid Levels DOI Open Access
Michele Linsalata, Laura Prospero, Antonia Ignazzi

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2483 - 2483

Published: April 5, 2025

Background: Patients with irritable bowel syndrome (IBS) often experience comorbid psychological conditions, notably depression and anxiety. Evidence suggests that these conditions are linked to gut barrier dysfunction, dysbiosis, chronic inflammation. All factors central IBS pathophysiology mood disturbances. Polyunsaturated fatty acids (PUFAs) play crucial roles in modulating inflammation depression. This study examined the associations among intestinal permeability, PUFA profiles, low-grade inflammation, severity patients diarrhea (IBS-D). Methods: Forty-three IBS-D (7 men, 36 women; 44.56 ± 1.52 years) were categorized into depressed (IBS-D(d+)) non-depressed (IBS-D(d-)) groups according scores on subscale of Symptom Checklist-90-Revised (SCL-90-R). Biomarkers small permeability (s-IP) assessed urine blood, alongside erythrocyte membrane composition, indices. Results: (d+) exhibited elevated s-IP altered metabolism compared their (d-) counterparts. Additionally, first group, omega-3 concentrations inversely correlated biomarkers, while omega-6/omega-3 ratio showed a positive correlation. Moreover, is significantly associated markers levels. Lastly, higher levels dysbiosis pro-inflammatory cytokines than patients. Conclusions: These findings highlight interplay between integrity depression, suggesting profiles could represent novel therapeutic targets for managing this population. was registered ClinicalTrials.gov (NCT03423069), date registration 30 January 2018.

Language: Английский

Citations

0