Published: Jan. 1, 2024
Language: Английский
Cell, Journal Year: 2024, Volume and Issue: 187(14), P. 3461 - 3495
Published: June 20, 2024
Developmental biology-the study of the processes by which cells, tissues, and organisms develop change over time-has entered a new golden age. After molecular genetics revolution in 80s 90s diversification field early 21st century, we have phase when powerful technologies provide approaches open unexplored avenues. Progress has been accelerated advances genomics, imaging, engineering, computational biology emerging model systems ranging from tardigrades to organoids. We summarize how revolutionary led remarkable progress understanding animal development. describe classic questions gene regulation, pattern formation, morphogenesis, organogenesis, stem cell are being revisited. discuss connections development with evolution, self-organization, metabolism, time, ecology. speculate developmental might evolve an era synthetic biology, artificial intelligence, human engineering.
Language: Английский
Citations
10
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Abstract A critical phase of mammalian brain development takes place after birth. Neurons the mouse neocortex undergo dramatic changes in their morphology, physiology, and synaptic connections during first postnatal month, while properties immature neurons, such as capacity for robust axon outgrowth, are lost. The genetic epigenetic programs controlling prenatal well studied, but our understanding transcriptional mechanisms that regulate neuronal maturation is comparatively lacking. By integrating chromatin accessibility gene expression data from two subtypes neocortical pyramidal neurons neonatal maturing brain, we predicted a role Krüppel-Like Factor (KLF) family Transcription Factors developmental regulation neonatally expressed genes. Using multiplexed CRISPR Interference (CRISPRi) knockdown strategy, found shift KLF activators (Klf6, Klf7) to repressors (Klf9, Klf13) early functions ‘switch’ activate, then repress set shared targets with cytoskeletal including Tubb2b Dpysl3 . We demonstrate this switch buffered by redundancy between paralogs, which CRISPRi strategy equipped overcome study. Our results indicate competition within regulates conserved component program may underlie loss intrinsic growth neurons. This could facilitate transition refinement required stabilize mature circuits.
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 187 - 187
Published: Feb. 12, 2025
This essay presents two lines of argument to suggest that the extension into adulthood specific phenotypic differentiation processes, typical early development, is fundamental evolution cognition. The first these organized in three steps. step reviews various studies human highlighting it has slowed down throughout compared great apes. second explores relationship between this development and third discusses evolutionary comparative analyses show a correlation cognitive processes developmental changes. line examines concepts phenotype. First, phenotype are reviewed correspondence meanings word plasticity (i.e., as ability alternate or shape), concluded all phenotypes -rigid, plastic, reversible-fit meaning shaping. It proposed phenotypical process can be seen continuous series functional differentiations occur at different times during life organism contextual points, both inside outside organism. Finally, brief recapitulation presented focused on supporting formation behavioral sequence shaping environmental interactions from most general particular.
Language: Английский
Citations
0
Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
The human brain is characterized by impressive cognitive abilities. neocortex the seat of higher cognition, and expansion a hallmark evolution. While developmental programs are similar in different species, timing transitions capacity neural progenitor cells (NPCs) to proliferate differ, contributing increased production neurons during cortical development. Here, we review epigenetic regulation corticogenesis, focusing mostly on humans while building knowledge from studies mice. We discuss metabolic-epigenetic interplay as potential mechanism integrate extracellular signals into chromatin. Moreover, synthesize current understanding how metabolic deregulation can cause neurodevelopmental disorders. Finally, outline be investigated using organoid models.
Language: Английский
Citations
0
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(11), P. 740 - 755
Published: Oct. 8, 2024
Language: Английский
Citations
2
Published: Jan. 1, 2024
Language: Английский
Citations
2