ChemBioChem,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Nov. 6, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
recognized
globally
as
one
of
the
most
lethal
tumors,
presenting
a
significant
menace
to
patients’
lives
owing
its
exceptional
aggressiveness
and
tendency
recur.
Transcatheter
hepatic
arterial
chemoembolization
(TACE)
therapy,
first‐line
treatment
option
for
patients
with
advanced
HCC,
has
been
proven
effective.
However,
it
disheartening
that
nearly
40
%
exhibit
resistance
this
therapy.
Consequently,
review
delves
into
metabolic
aspects
glucose
metabolism
explore
underlying
mechanisms
behind
TACE
propose
potentially
fruitful
therapeutic
strategies.
The
ultimate
objective
present
novel
insights
development
personalized
methods
targeting
HCC.
World Journal of Surgical Oncology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 29, 2025
Neuropilin
and
tolloid-like
2
(NETO2)
facilitates
the
progression
of
various
cancers,
but
its
role
in
hepatocellular
carcinoma
(HCC)
is
not
known.
This
study
aimed
to
assess
potential
targeting
NETO2
HCC
relationship
with
STAT3/C-MYC
pathway.
cells
(Huh7
MHCC-97
H)
were
cultured
transfected
control
siRNA
(siCtrl),
(siNETO2),
overexpression
(oeCtrl),
or
(oeNETO2),
non-transfected
used
as
blank
controls.
mRNA
protein
expressions
reduced
both
Huh7
H
cells.
EdU
CCK-8
assays
indicated
that
cell
proliferation
was
decreased
after
siNETO2
transfection
TUNEL
assay
found
revealed
apoptosis
rate
greater
cells,
tended
be
(but
difference
statistically
significant).
Transwell
invasion
number
invasive
transfection.
Cell
scratch
migration
significantly
different
Western
blotting
p-STAT3
C-MYC
Overexpression
experiments
promoted
oeNETO2
knockdown
suppresses
proliferation,
invasion,
inactivates
pathway,
suggesting
a
target
for
treatment.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 7, 2025
Cancer
treatment
has
long
been
hindered
by
the
complexity
of
tumor
microenvironment
(TME)
and
mechanisms
that
tumors
employ
to
evade
immune
detection.
Recently,
combination
checkpoint
inhibitors
(ICIs)
anti-angiogenic
therapies
emerged
as
a
promising
approach
improve
cancer
outcomes.
This
review
delves
into
role
immunostimulatory
molecules
ICIs
in
enhancing
anti-tumor
immunity,
while
also
discussing
therapeutic
potential
strategies
cancer.
In
particular,
we
highlight
critical
endoplasmic
reticulum
(ER)
stress
angiogenesis.
Moreover,
explore
macrophage
reprogramming
bolster
with
focus
on
restoring
phagocytic
function,
modulating
hypoxic
environments,
targeting
cytokines
chemokines
shape
responses.
By
examining
underlying
combining
therapies,
recent
clinical
trials
discuss
biomarkers
guide
predict
efficacy.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1260 - 1260
Published: May 21, 2025
Background/Objectives:
Metabolic-dysfunction-associated
steatotic
liver
disease
(MASLD)
progresses
from
hepatic
steatosis
to
hepatocellular
carcinoma
(HCC)
as
a
result
of
systemic
immunometabolic
dysfunction.
This
review
summarizes
the
key
roles
innate
and
adaptive
immune
mechanisms
driving
injury,
fibrogenesis,
carcinogenesis
in
MASLD.
Methods:
A
comprehensive
literature
was
performed
using
PubMed
identify
relevant
published
studies.
Eligible
articles
included
original
research
clinical
studies
addressing
immunological
metabolic
MASLD,
well
emerging
therapeutic
strategies.
Results:
We
highlight
cytokine
networks,
gut–liver
axis,
cell
reprogramming.
Emerging
strategies,
including
inhibitors,
anti-fibrotic
agents,
modulators,
nutraceuticals,
offer
several
indications
for
attenuating
MASLD
progression
reducing
prevalence
extrahepatic
manifestations.
Conclusions:
Given
heterogeneity
personalized
combination-based
approaches
targeting
both
inflammation
stress
are
essential
effective
management
prevention
complications.
AJP Cell Physiology,
Journal Year:
2024,
Volume and Issue:
327(2), P. C291 - C309
Published: June 3, 2024
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
a
family
of
"forever
chemicals"
including
perfluorooctane
sulfonate
(PFOS).
These
toxic
chemicals
do
not
break
down
in
the
environment
or
our
bodies.
In
human
body,
PFOS
perfluoroctanoic
acid
(PFOA)
have
half-life
(
World Journal of Gastrointestinal Oncology,
Journal Year:
2024,
Volume and Issue:
16(6), P. 2769 - 2780
Published: June 14, 2024
BACKGROUND
Wnt/FZD-mediated
signaling
pathways
are
activated
in
more
than
90%
of
hepatocellular
carcinoma
(HCC)
cell
lines.
As
a
well-known
secretory
glycoprotein,
Wnt3
can
interact
with
FZD
receptors
on
the
surface,
thereby
activating
Wnt/β-catenin
pathway.
However,
N-glycosylation
modification
site
and
effect
this
biological
function
protein
still
unclear.
AIM
To
investigate
HCC
cells.
METHODS
Site-directed
mutagenesis
was
used
to
verify
sites,
actinomycin
D
treatment
detect
stability
after
site-directed
mutation,
binding
mutant
FZD7
observed
by
laser
confocal
microscopy,
effects
mutation
pathway
progression
cells
were
detected
western
blot
experiments.
RESULTS
has
two
N-glycosylation-modified
sites
(Asn90
Asn301);
when
single
at
amino
acid
301
is
mutated,
weakened;
ability
decreases
both
mutated
simultaneously;
level
proteins
related
downregulated.
Cell
proliferation,
migration
invasion
also
weakened
case
double-site
mutations.
CONCLUSION
These
results
indicate
that
inhibiting
Wnt3,
migration,
colony
formation
abilities
liver
cancer
be
weakened,
which
might
provide
new
therapeutic
strategies
for
clinical
future.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1837 - 1837
Published: May 11, 2024
Hepatocellular
carcinoma
is
a
malignant
tumor
that
originates
from
hepatocytes
in
an
inflammatory
substrate
due
to
different
degrees
of
liver
fibrosis
up
cirrhosis.
In
recent
years,
there
has
been
growing
interest
the
role
played
by
complex
interrelationship
between
hepatocellular
and
its
microenvironment,
capable
influencing
tumourigenesis,
neoplastic
growth,
progression
or
even
inhibition.
The
microenvironment
made
intricate
network
mesenchymal
cells,
immune
system
extracellular
matrix,
growth
factors,
as
well
proinflammatory
cytokines
translocated
bacterial
products
coming
intestinal
via
enterohepatic
circulation.
aim
this
paper
review
HCC
describe
possible
implications
choice
most
appropriate
therapeutic
scheme
prediction
response
resistance
currently
applied
treatments
development
future
perspectives,
order
circumvent
break
down
tumor’s
defensive
fort.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 31, 2024
Leukocyte
cell-derived
chemotaxin-2
(LECT2)
is
an
important
cytokine
synthesized
by
liver.
Significant
research
interest
stimulated
its
crucial
involvement
in
inflammatory
response,
immune
regulation,
disease
occurrence
and
development.
However,
bibliometric
study
on
LECT2
lacking.
In
order
to
comprehend
the
function
operation
of
human
illnesses,
we
examined
pertinent
studies
investigation
Web
Science
database,
followed
utilizing
CiteSpace,
VOSview,
Scimago
Graphica
for
assessing
yearly
quantity
papers,
countries/regions
involved,
establishments,
authors,
publications,
citations,
key
terms.
Then
summarized
current
hotspots
this
field.
Our
found
that
literature
related
has
a
fluctuating
upward
trend.
“Angiogenesis”,
“ALECT2”,
“diagnosis”,
“biliary
atresia”
are
investigative
frontiers.
findings
indicated
liver
diseases
(e.g.
fibrosis
hepatic
cell
carcinoma),
systemic
disease,
amyloidosis
focus
LECT2.
The
outcomes
not
exceptional.
We
hope
promote
scientific
exploit
potential
clinical
diagnosis
treatment
through
comprehensive
review.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
183, P. 306 - 317
Published: June 3, 2024
Advanced
hepatocellular
carcinoma
(HCC)
is
one
of
the
most
challenging
cancers
because
its
heterogeneous
and
aggressive
nature,
precluding
use
curative
treatments.
Sorafenib
(SOR)
first
approved
molecular
targeting
agent
against
mitogen-activated
protein
kinase
(MAPK)
pathway
for
noncurative
therapy
advanced
HCC;
yet,
any
clinically
meaningful
benefits
from
treatment
remain
modest,
are
accompanied
by
significant
side
effects.
Here,
we
hypothesized
that
using
a
nanomedicine
platform
to
co-deliver
SOR
with
another
drug,
metformin
(MET),
could
tackle
these
issues.
A
micelle
self-assembled
amphiphilic
polypeptide
methoxy
poly(ethylene
glycol)-block-poly(L-phenylalanine-co-l-glutamic
acid)
(mPEG-b-P(LP-co-LG))
(PM)
was
therefore
designed
combinational
delivery
two
targeted
drugs,
MET,
hepatomas.
Compared
free
proposed,
dual
drug-loaded
(PM/SOR+MET)
enhanced
drugs'
half-life
in
bloodstream
drug
accumulation
at
tumor
site,
thereby
inhibiting
growth
effectively
preclinical
subcutaneous,
orthotopic
patient-derived
xenograft
hepatoma
models
without
causing
systemic
organ
toxicity.
Collectively,
findings
demonstrate
an
effective
dual-targeting
strategy
treating
HCC,
which
may
have
translational
potential
cancer
therapeutics.
STATEMENT
OF
SIGNIFICANCE:
Treatment
remains
formidable
challenge
due
nature
limitations
inherent
current
therapies.
Despite
advancements
therapies,
such
as
(SOR),
their
modest
clinical
coupled
adverse
effects
underscore
urgent
need
more
efficacious
less
toxic
modalities.
Our
research
presents
new
synergistically
combines
within
specialized
diblock
micelle,
aiming
enhance
therapeutic
efficacy
while
reducing
This
innovative
approach
not
only
exhibits
marked
antitumor
across
multiple
HCC
but
also
significantly
reduces
toxicity
associated
dual-molecular
unveils
promising
potentially
offering
safer
alternatives
potential.
